[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-127890-en":3,"doc-seo-127890-105":30,"detail-sidebar-cat-0-en-105":92},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},127890,2336474459895,"Aria","https://ap-avatar.wpscdn.com/avatar/22000baeef7a5ed0655?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786071322749376916",8,"Research & Report","Contrast-enhanced CT radiomics combined with multiple machine learning algorithms for preoperative identification of lymph node metastasis in pancreatic ductal adenocarcinoma","Radiomics features extracted from contrast-enhanced CT were combined with multiple machine learning algorithms to improve preoperative identification of lymph node metastasis in pancreatic ductal adenocarcinoma (PDAC). A cohort of 128 pathologically confirmed PDAC patients undergoing surgical resection was randomized into training (n=93) and validation (n=35) sets. Thirteen algorithms and multiple combinations were evaluated using AUC, and the best-performing setup generated a Radscore, then integrated with clinical factors using multivariate logistic regression. Performance was assessed via ROC, calibration, and decision curve analysis.","TYPE Original Research PUBLISHED 13 September 2024 DOI 10.3389/fonc.2024.1342317  \nOPEN ACCESS  \nEDITED BY  \nKuangyu Shi,  \nUniversity of Bern, Switzerland  \nREVIEWED BY Ying Li,  \nFudan University, China Gang Ren,  \nAir Force General Hospital PLA, China  \n*CORRESPONDENCE Shangeng Weng  \n [shangeng@sina.com](shangeng@sina.com)  \nRECEIVED 22 November 2023  \nACCEPTED 23 August 2024  \nPUBLISHED 13 September 2024  \nCITATION  \nHuang Y, Zhang H, Chen L, Ding Q, Chen D, Liu G, Zhang X, Huang Q, Zhang D and Weng S (2024) Contrast-enhanced CT radiomics combined with multiple machine learning algorithms for preoperative identification of lymph node metastasis in pancreatic ductal adenocarcinoma.  \nFront. Oncol. 14:1342317 .  \ndoi: 10.3389/fonc.2024.1342317  \nCOPYRIGHT  \n© 2024 Huang, Zhang, Chen, Ding, Chen, Liu, Zhang, Huang, Zhang and Weng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nContrast-enhanced CT radiomics combined with multiple machine learning algorithms for preoperative identification of lymph node metastasis in pancreatic ductal adenocarcinoma  \nYue Huang 1,2,3, Han Zhang 1,2,3, Lingfeng Chen 1,2,3, Qingzhu Ding 1,2,3, Dehua Chen 4, Guozhong Liu 1,3, Xiang Zhang 1,2,3, Qiang Huang 1,2,3, Denghan Zhang 1,2,3 and Shangeng Weng 1,2,3,5,6*  \n1 Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China, 2Fujian Abdominal Surgery Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China, 3 National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China, 4 Department of Radiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China, 5 Fujian Provincial Key Laboratory of Precision Medicine for Cancer, The First Affiliated Hospital of Fujian Medical University, Fuzhou,  \nFujian, China, 6Clinical Research Center for Hepatobiliary Pancreatic and Gastrointestinal Malignant Tumors Precise Treatment of Fujian Province, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China  \nObjectives: This research aimed to assess the value of radiomics combined with multiple machine learning algorithms in the diagnosis of pancreatic ductaladenocarcinoma (PDAC) lymph node (LN) metastasis, which is expected to provide clinical treatment strategies.  \nMethods: A total of 128 patients with pathologically confirmed PDAC and who underwent surgical resection were randomized into training (n=93) and validation (n=35) groups. This study incorporated a total of 13 distinct machine learning algorithms and explored 85 unique combinations of these algorithms. The area under the curve (AUC) of each model was computed. The model with the highest mean AUC was selected as the best model which was selected to determine the radiomics score (Radscore). The clinical factors were examined by the univariate and multivariate analysis, which allowed for the identification offactors suitable for clinical modeling. The multivariate logistic regression was used to create a combined model using Radscore and clinical variables. The diagnostic performance was assessed by receiver operating characteristic curves, calibration curves, and decision curve analysis (DCA) .  \nResults: Among the 233 models constructed using arterial phase (AP), venous phase (VP), and AP+VP radiomics features, the model built by applying AP+VP radiomics features and a combination of Lasso+Logistic algorithm had the highest mean AUC. A clinical model was eventually constructed using C","cbCaipNHaazBNZ0a","https://ap.wps.com/l/cbCaipNHaazBNZ0a","pdf",5092526,1,14,"English","en",105,"# Objectives\n# Methods\n# Results\n# Conclusions\n# Keywords\n# Introduction","[{\"question\":\"What clinical problem does the study address?\",\"answer\":\"The study evaluates radiomics features from contrast-enhanced CT combined with multiple machine learning algorithms for diagnosing lymph node metastasis before surgery.\"},{\"question\":\"How were patients and datasets organized?\",\"answer\":\"Model selection and performance were compared across these cohorts.\"},{\"question\":\"Which model components produced the best diagnostic performance?\",\"answer\":\"A clinical model was further built using CA199 and tumor size and then combined with Radscore in multivariate logistic regression.\"}]","Contrast-enhanced CT radiomics combined with multiple machine learning algorithms for preoperative identification of lymph node metastasis in 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