[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-439763-en":59,"doc-seo-439763-105":79},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":72,"language_code":73,"site_id":74,"html_lang":73,"table_of_contents":75,"faqs":76,"seo_title":77,"seo_description":66,"update_tm":78,"read_time":46},439763,1374404737137,"Adam","https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Continued Versus Interrupted Oral Anticoagulation During Transcatheter Aortic Valve Replacement in Patients With Atrial Fibrillation - Meta-Analysis","Atrial fibrillation patients undergoing transcatheter aortic valve replacement (TAVR) often require long-term oral anticoagulants, creating uncertainty about whether peri-procedural continuation is safer or should be interrupted. This meta-analysis systematically pooled available evidence and compared TAVR outcomes between continued and interrupted oral anticoagulation strategies. Pooled results showed comparable all-cause and cardiovascular mortality, similar bleeding and vascular complication risks, and no clear difference in stroke rates, supporting continuation as a viable periprocedural option.","Continued Versus Interrupted Oral Anticoagulation During Transcatheter Aortic Valve Replacement in Patients With Atrial Fibrillation: A Meta-Analysis  \nHritvik Jain, MBBS,1 Nandan Patel, MBBS,1 Muhammad Daoud Tariq, MBBS,2 Ali Saad Al-Shammari, MBChB,3 Rozi Khan, MD,4 Jyoti Jain, MBBS,1 Rahul Patel, MD,5 Faizan Ahmed, MD,6 Raheel Ahmed, MBBS, MRCP, 7, * and Thomas Alexander, MD, FACC, FSCAI8  \nIntroduction: A substantial number of patients undergoing transcatheter aortic valve replacement (TAVR) require long-term oral anticoagulants (OAC) owing to comorbidities. This study examined whether continuing oral anticoagulation periprocedurally during TAVR is as safe and effective as interrupting it.  \nMethods: A systematic search of the major databases was performed to identify relevant studies. Effect estimates were calculated using risk ratios (RR) and 95% CIs by pooling the data  \nFrom the 1Department of Cardiology, All India Institute of Medical Sciences (AIIMS), Jodhpur, India; 2Department of Internal Medicine, Foundation University Medical College, Islamabad, Pakistan; 3Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq; 4Department of Internal Medicine, University of Pittsburgh Medical Center, Harrisburg, PA; 5Department of Internal Medicine, University of North Carolina Health Blue Ridge, Morganton, NC; 6Department of Cardiology, Duke University Hospital, Durham, NC; 7Department of Cardiology, National Heart and Lung Institute, Imperial College London, London, United Kingdom; and 8Department of Cardiology, Corpus Christi Medical Center, Corpus Christi, TX.  \nThe authors have no conflicts of interest to declare.  \nSupplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www. [americantherapeutics.com](americantherapeutics.com)).  \nH. Jain: Conceptualization, methodology, formal analysis, software, writing  \n—original draft, writing—review & editing; N. Patel: Conceptualization, investigation, validation, writing—original draft, writing—review & editing; M. Daoud Tariq: Investigation, formal analysis, software, writing—original draft, writing—review & editing; A. S. Al-Shammari: Investigation, conceptualization, validation, writing—original draft, writing—review & editing; R. Khan: Supervision, validation, methodology, conceptualization, writing—original draft, writing—review & editing; J. Jain: Methodology, software, validation, writing—original draft, writing—review & editing; R. Patel: Validation, conceptualization, writing—original draft, writing—review & editing; F. Ahmed: Methodology, software, writing—original draft, writing—review & editing; R. Ahmed: Supervision, methodology, writing—original draft, writing—review & editing; T. Alexander: Supervision, resources, validation, methodology, project administration, writing—original draft, writing  \n—review & editing.  \n*Address for correspondence: Raheel Ahmed, MBBS, MRCP, Department of Cardiology, National Heart and Lung Institute, Imperial College London,  \nLondon SW3 6LY, UK. E-mail: [r.ahmed21@imperial.ac.uk](r.ahmed21@imperial.ac.uk)  \nCopyright © 2025 The Author(s) . Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nusing the inverse-variance random effects model. Statistical significance was set at P , 0.05.  \nResults: Four studies were included, with 2962 patients undergoing TAVR with continued OAC (n = 1318) and interrupted OAC (n = 1644) . The pooled analysis demonstrated that TAVR with continued OAC had comparable risks for all-cause mortality (RR: 0.91; 95% CI, 0.62–1.34; P = 0.64), cardiovascular mortality (RR: 0.89; 95% CI, 0.43–1.84; P = 0.76), stroke (RR: 0.67; 95% CI, 0.42–1.","cbCaiixcYlZMGNsV","https://ap.wps.com/l/cbCaiixcYlZMGNsV","pdf",808565,"English","en",105,"# Introduction\n# Methods\n# Results\n# Conclusions\n# Keywords","[{\"question\":\"What question does the meta-analysis address regarding TAVR in atrial fibrillation patients?\",\"answer\":\"It evaluates whether continuing oral anticoagulation during the peri-procedural period is as safe and effective as interrupting anticoagulation during TAVR.\"},{\"question\":\"How were study effects estimated in the analysis?\",\"answer\":\"Risk ratios (RR) with 95% confidence intervals (CIs) were calculated by pooling data, using an inverse-variance random effects model.\"},{\"question\":\"What did the pooled results show about safety and effectiveness?\",\"answer\":\"Continued oral anticoagulation demonstrated comparable safety and efficacy versus interrupted oral anticoagulation for mortality, major bleeding, major vascular complications, and generally similar stroke risk.\"}]","Continued Versus Interrupted Oral Anticoagulation During Transcatheter Aortic Valve Replacement in Patients With Atrial Fibrillation - Meta-Analysis | PDF",1790690125,{"code":4,"msg":80,"data":81},"ok",{"site_id":74,"language":73,"slug":82,"title":65,"keywords":83,"description":66,"schema_data":84,"social_meta":137,"head_meta":139,"extra_data":141,"updated_unix":142},"continued-versus-interrupted-oral-anticoagulation-during-transcatheter-aortic-valve-replacement-in-patients-with-atrial-fibrillation-meta-analysis","",{"@graph":85,"@context":136},[86,100,119],{"@type":87,"itemListElement":88},"BreadcrumbList",[89,93,95,98],{"item":90,"name":91,"@type":92,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":94,"name":9,"@type":92,"position":14},"https://docshare.wps.com/document/",{"item":96,"name":35,"@type":92,"position":97},"https://docshare.wps.com/document/healthcare/",3,{"item":99,"name":65,"@type":92,"position":19},"https://docshare.wps.com/document/continued-versus-interrupted-oral-anticoagulation-during-transcatheter-aortic-valve-replacement-in-patients-with-atrial-fibrillation-meta-analysis/439763/",{"url":99,"name":65,"@type":101,"image":102,"author":107,"headline":65,"publisher":109,"fileFormat":112,"inLanguage":73,"description":66,"dateModified":113,"datePublished":113,"encodingFormat":112,"isAccessibleForFree":114,"interactionStatistic":115},"DigitalDocument",{"url":103,"@type":104,"width":105,"height":106},"https://docshare.wps.com/thumbnails/continued-versus-interrupted-oral-anticoagulation-during-transcatheter-aortic-valve-replacement-in-patients-with-atrial-fibrillation-meta-analysis/439763.png","ImageObject",300,407,{"name":63,"@type":108},"Person",{"url":90,"name":110,"@type":111},"DocShare","Organization","application/pdf","2026-09-29",true,{"@type":116,"interactionType":117,"userInteractionCount":8},"InteractionCounter",{"@type":118},"ViewAction",{"@type":120,"mainEntity":121},"FAQPage",[122,128,132],{"name":123,"@type":124,"acceptedAnswer":125},"What question does the meta-analysis address regarding TAVR in atrial fibrillation patients?","Question",{"text":126,"@type":127},"It evaluates whether continuing oral anticoagulation during the peri-procedural period is as safe and effective as interrupting anticoagulation during TAVR.","Answer",{"name":129,"@type":124,"acceptedAnswer":130},"How were study effects estimated in the analysis?",{"text":131,"@type":127},"Risk ratios (RR) with 95% confidence intervals (CIs) were calculated by pooling data, using an inverse-variance random effects model.",{"name":133,"@type":124,"acceptedAnswer":134},"What did the pooled results show about safety and effectiveness?",{"text":135,"@type":127},"Continued oral anticoagulation demonstrated comparable safety and efficacy versus interrupted oral anticoagulation for mortality, major bleeding, major vascular complications, and generally similar stroke risk.","https://schema.org",{"og:url":99,"og:type":138,"og:title":65,"og:site_name":110,"og:description":66},"article",{"robots":140,"canonical":99},"index,follow",{"doc_id":61,"site_id":74},1790718763]