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The work investigates the mechanisms by which selection pressures sculpt mutation patterns while emphasizing a lung biology context rather than overt disease. It is presented with comprehensive author affiliations, a dated posting reference, and formal scholarly metadata including a DOI and open-access licensing terms. Declarations note potential competing interests and related consultancy or inventor roles tied to lung cancer detection and treatment efforts.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/context-dependent-selection-sculpts-mutational-landscapes-in-the-normal-lung/349445/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/context-dependent-selection-sculpts-mutational-landscapes-in-the-normal-lung/349445.png","ImageObject",300,407,{"name":92,"@type":93},"Well Done","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main focus of this study?","Question",{"text":113,"@type":114},"It focuses on how context-dependent selection shapes mutational landscapes in the normal lung.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"When was the work posted and where can it be referenced?",{"text":118,"@type":114},"The posting date is July 2nd, 2026, and the work is referenced with a DOI link.",{"name":120,"@type":111,"acceptedAnswer":121},"Are there any declarations related to competing interests?",{"text":122,"@type":114},"Yes. The document includes additional declarations describing potential competing interests, including consulting relationships and inventor/co-inventor roles connected to lung cancer related methods and applications.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},349445,1790189753,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},5909892210082,"https://ap-avatar.wpscdn.com/avatar/56001069da27c9f41e8?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789614185077863061","Context-dependent selection sculpts mutational landscapes in the normal lung  \nEdward Evans  \nUniversity of Colorado Anschutz Medical Campus  \nFerriol Calvet  \nInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology [https://orcid.org/0000-0003-1841-9881](https://orcid.org/0000-0003-1841-9881)  \nFabio Marongiu  \nUniversity of Cagliari  \nFaiz Jabbar  \nCrick Institute  \nElan Eisenmesser  \nUniversity of Colorado Denver – Anschutz Medical Campus  \nWilliam Hill  \nThe University of Manchester  \nClare Weeden  \nPersonalised Oncology Division, Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne, Parkville, Australia  \nOriol Pich  \nThe Francis Crick Institute [https://orcid.org/0000-0002-1956-1882](https://orcid.org/0000-0002-1956-1882)  \nMoumita Ghosh  \n[moumita.ghosh@cuanschutz.edu](moumita.ghosh@cuanschutz.edu)  \nRobert Keith  \nDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine.  \nYork Miller  \nDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine;Veterans Affairs Eastern Colorado Healthcare System, Aurora, Colorado.  \nDaniel Merrick  \nDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.  \nClara Troccoli  \nUniversity of Colorado Anschutz Medical Campus  \nAndrew Rowan  \nTranslational Cancer Therapeutics Laboratory, Francis Crick Institute  \nTakahiro Karasaki  \nCrick Institute  \nSelvaraju Veeriah  \nCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute  \nDavid Moore  \nUniversity College London [https://orcid.org/0000-0002-6296-1312](https://orcid.org/0000-0002-6296-1312)  \nMihaela Angelova  \nCrick Institute [https://orcid.org/0000-0002-0495-9695](https://orcid.org/0000-0002-0495-9695)  \nOlivia Lucas  \nUniversity College of London  \nCharlotte Grieco  \nFrancis Crick Institute [https://orcid.org/0000-0003-3177-7245](https://orcid.org/0000-0003-3177-7245)  \nLydia Liu  \nThe Francis Crick Institute  \nCristina Naceur-Lombardelli  \nUCL Cancer Institute [https://orcid.org/0000-0002-7097-0307](https://orcid.org/0000-0002-7097-0307)  \nMariam Jamal-Hanjani  \nCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute  \n[https://orcid.org/0000-0003-1212-1259](https://orcid.org/0000-0003-1212-1259)  \nNuria Lopez-Bigas  \nIRB Barcelona  \nEmilia Lim  \nUniversity of British Columbia  \nCharles Swanton  \nThe Francis Crick Institute [https://orcid.org/0000-0002-4299-3018](https://orcid.org/0000-0002-4299-3018)  \nJames DeGregori  \nUniversity of Colorado Anschutz Medical Campus [https://orcid.org/0000-0002-1287-1976](https://orcid.org/0000-0002-1287-1976)  \nBiological Sciences-Article  \nKeywords:  \nPosted Date: July 2nd, 2026  \nDOI: [https://doi.org/10.21203/rs.3.rs-10195584/v1](https://doi.org/10.21203/rs.3.rs-10195584/v1)  \nLicense: 􀁱 􀅏 This work is licensed under a Creative Commons Attribution 4.0 International License.  \nRead Full License  \nAdditional Declarations: Yes there is potential Competing Interest. M.J-H. has consulted for Astex Pharmaceuticals, Pfizer and Achilles Therapeutics, and is a member of, the Achilles Therapeutics Scientific Advisory Board and Steering Committee, has received speaker honoraria from Pfizer, Astex Pharmaceuticals, Oslo Cancer Cluster, Bristol Myers Squibb, Genentech and GenesisCare. MJ-H is listed as a co-inventor on a European patent application relating to methods to detect lung cancer  \nPCT/US2017/028013), this patent has been licensed to commercial entities and, under terms of employment, [M.J.-H. is](M.J.-H. is) due a share of any revenue generated from such license(s), and is also listed asa co-inventor on the GB priority patent application (GB2400424 .4) with title: Treatment and Prevention of Lung Cancer. MJ-H holds a Revenue Share Agreement with UCL Business Ltd. S.V is a co-inventor to a patent of methods for detecting molecules in a sa","cbCaiv2MgHJ3Wl3t","https://ap.wps.com/l/cbCaiv2MgHJ3Wl3t","pdf",1745929,44,"English","# Context-dependent selection sculpts mutational landscapes in the normal lung\n## Authors and affiliations\n## Keywords and posting metadata\n## DOI, license, and competing interest declarations","[{\"question\":\"What is the main focus of this study?\",\"answer\":\"It focuses on how context-dependent selection shapes mutational landscapes in the normal lung.\"},{\"question\":\"When was the work posted and where can it be referenced?\",\"answer\":\"The posting date is July 2nd, 2026, and the work is referenced with a DOI link.\"},{\"question\":\"Are there any declarations related to competing interests?\",\"answer\":\"Yes. The document includes additional declarations describing potential competing interests, including consulting relationships and inventor/co-inventor roles connected to lung cancer related methods and applications.\"}]","Context-dependent selection sculpts mutational landscapes in the normal lung | PDF",1790083332,111]