[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-374260-105":59,"doc-detail-374260-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","construction-and-validation-of-a-novel-nomogram-for-prediction-of-lymph-node-metastasis-in-her2-positive-breast-cancer-based-on-the-optimal-number-of-examined-lymph-nodes-for-accurate-nodal-staging","Construction and validation of a novel nomogram for prediction of lymph node metastasis in HER2-positive breast cancer - based on the optimal number of examined lymph nodes for accurate nodal staging","","This study constructs and validates a novel nomogram predicting lymph node metastasis in HER2-positive breast cancer using the optimal number of examined lymph nodes (ELNs) to support accurate nodal staging. Data from 4,040 patients were drawn from the SEER database and split into training and validation cohorts. The optimal ELN count was determined by piecewise linear regression, while associations and model predictors were assessed with logistic regression and random forest. Model discrimination, calibration, and decision-curve performance were evaluated, yielding strong predictive accuracy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/construction-and-validation-of-a-novel-nomogram-for-prediction-of-lymph-node-metastasis-in-her2-positive-breast-cancer-based-on-the-optimal-number-of-examined-lymph-nodes-for-accurate-nodal-staging/374260/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/construction-and-validation-of-a-novel-nomogram-for-prediction-of-lymph-node-metastasis-in-her2-positive-breast-cancer-based-on-the-optimal-number-of-examined-lymph-nodes-for-accurate-nodal-staging/374260.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of this study?","Question",{"text":112,"@type":113},"To construct and validate a novel nomogram that predicts lymph node metastasis in HER2-positive breast cancer using the optimal number of examined lymph nodes for accurate nodal staging.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients selected and split for analysis?",{"text":117,"@type":113},"A total of 4,040 HER2-positive breast cancer patients were included from the SEER database and randomly allocated into training and validation cohorts in a 7:3 ratio.",{"name":119,"@type":110,"acceptedAnswer":120},"What factors were used in the nomogram?",{"text":121,"@type":113},"Independent predictive variables included the optimal number of ELNs, radiotherapy status, chemotherapy status, T stage, and grade, identified using logistic regression and random forest.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},374260,1790241555,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Sun et al. BMC Women's Health (2025) 25:132 BMC Women's Health  \n[https://doi.org/10.1186/s12905-025-03663-w](https://doi.org/10.1186/s12905-025-03663-w)  \nRESEARCH Open Access  \nConstruction and validation of a novel nomogram for prediction of lymph node metastasis in HER2-positive breast cancer: based on the optimal number of examined lymph nodes for accurate nodal staging  \nZhen-Dong Sun 1, Yan Zhang2, Yu-ShenYang 1, Chu-Yun Liu 1, Meng-Qin Pei 1, Wei-Dong Fu2* and He-Han He 1*  \nAbstract  \nPurpose This study aimed to construct and validate a novel nomogram for prediction of lymph node metastasis in HER2-positive breast cancer based on the optimal number of examined lymph nodes (ELNs) for accurate nodal staging.  \nMethods We included 4,040 patients diagnosed with HER2-positive breast cancer from the SEER database, randomly allocating them into training and validation cohorts in a 7:3 ratio. The optimal number of ELNs was identified via piecewise linear regression. The association of ELNs count with nodal migration was evaluated through Logistic Regression (LR) analysis and Random Forest (RF) . The nomogram was constructed, and its’ performance was evaluated by the receiver operating characteristic curves, calibration curve and Decision curve analysis curves.  \nResults The optimal number of ELNs was 13. LR and RF identified the optimal number of ELNs, radiotherapy status, chemotherapy status, T stage, and grade as independent predictive variables for node metastasis, which were used in the nomogram’s construction. And the area under the curve values for the nomogram were 0.829 (95% confidence interval (CI): 0 .813–0. 845) and 0.833 (95% CI:0 .808–0. 858) in the training and test split respectively, surpassing those of the optimal number of ELNs (0 . 649, 95% CI: 0.631–0.667 and 0. 676, 95% CI:0 .648–0. 704) . Calibration plots exhibited low Brier scores (0 . 150 for training split, 0.145 for test split) .  \nConclusion This study developed a novel nomogram that integrates the optimal number of ELNs with other independent risk factors, facilitating individualized prediction of lymph node metastasis in patients with HER2-positive breast cancer.  \nZhen-Dong Sun andYan Zhang share first authorship.  \n*Correspondence:  \nWei-Dong Fu [740831992@qq.com](740831992@qq.com)[ ](740831992@qq.com)He-Han He [15860905262@163.com](15860905262@163.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/l](vecommons.org/l)icenses/by-nc-nd/4.0/.  \nSun et al. BMC Women's Health (2025) 25:132 Page 2 of 12  \nKeywords Examined lymph node, Nodal staging, HER2-positive breast cancer, Nomogram, Radical resection, SEER database  \nIntroduction  \nIn America, breast cancer is the most frequently diagnosed cancer and the second leading cause of cancerrelated deaths among women [1]. It is estimated that in 2022, around 14% of female breast cancers exhibited HER2 overexpression [2]. Although the therapeutic target an","cbCaiviaxNnfTAvp","https://ap.wps.com/l/cbCaiviaxNnfTAvp","pdf",3324905,12,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Method\n## Patients and data collection","[{\"question\":\"What is the main purpose of this study?\",\"answer\":\"To construct and validate a novel nomogram that predicts lymph node metastasis in HER2-positive breast cancer using the optimal number of examined lymph nodes for accurate nodal staging.\"},{\"question\":\"How were patients selected and split for analysis?\",\"answer\":\"A total of 4,040 HER2-positive breast cancer patients were included from the SEER database and randomly allocated into training and validation cohorts in a 7:3 ratio.\"},{\"question\":\"What factors were used in the nomogram?\",\"answer\":\"Independent predictive variables included the optimal number of ELNs, radiotherapy status, chemotherapy status, T stage, and grade, identified using logistic regression and random forest.\"}]","Construction and validation of a novel nomogram for prediction of lymph node metastasis in HER2-positive breast cancer - based on the optimal number of examined lymph nodes for accurate nodal staging | PDF",1790201373]