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A retrospective cohort review covered patients with stage IA1 squamous cancer treated with cold knife cone or loop electrosurgical excision from 1994 to 2015, collecting diagnosis age, pre-conization findings, margin status, residual disease, recurrence and survival. Among 26 women followed a mean 44.6 months, no recurrent invasive cervical cancer or cervical-cancer deaths occurred, with excellent results.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/conservative-treatment-of-stage-ia1-cervical-carcinoma-without-lymphovascular-space-invasion-a-20-year-retrospective-study-in-brazil/383637/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/conservative-treatment-of-stage-ia1-cervical-carcinoma-without-lymphovascular-space-invasion-a-20-year-retrospective-study-in-brazil/383637.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the purpose of the retrospective study?","Question",{"text":112,"@type":113},"To evaluate recurrence rates and risk factors among women with stage IA1 cervical cancer without lymphovascular space invasion managed conservatively.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which treatment approaches were included in the study methods?",{"text":117,"@type":113},"Women with stage IA1 squamous cervical cancer treated with cold knife cone or loop electrosurgical excision between 1994 and 2015 were included.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main outcomes regarding recurrence and mortality?",{"text":121,"@type":113},"No patients were diagnosed with recurrent invasive cervical cancer, and there were no deaths due to cervical cancer or other causes in the cohort.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},383637,1790665950,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","Article published online: 2023-05-24  \nOriginal Article 201  \nConservative Treatment of Stage IA1 Cervical  \nCarcinoma Without Lymphovascular Space Invasion: A 20-year Retrospective Study in Brazil Tratamento conservador do câncer do colo do útero IA1 sem invasão linfovascular: estudo retrospectivo no Brasil  \nDaniele Lima Alberton 1,2 Mila Pontremoli Salcedo 1,3 Raquel Potrich Zen4 Charles Francisco Ferreira5 Kathleen Schmeler3 Suzana Arenhart Pessini2,5  \n1 Obstetrics and Gynecology Department, Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil  \n2 Obstetrics and Gynecology Department, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil  \n3 Department of Gynaecologic Oncology & Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States  \n4 Internal Medicine, Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil  \n5 Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil  \nRev Bras Ginecol Obstet 2023;45(4):201–206.  \nAddress for correspondence Daniele Lima Alberton, Rua Ramiro Barcellos, 2350, 90035-903, Porto Alegre, RS, Brazil  \n(e-mail: [danialberton@gmail.com](danialberton@gmail.com)).  \nAbstract  \nKeywords  \n► Uterine cervical neoplasms  \n► Conization  \n► Conservative treatment  \n► Recurrence  \n► Squamous cell carcinoma  \nPurpose: To evaluate recurrence rates and risk factors among women with stage IA1 cervical cancer without lymph vascular space invasion managed conservatively. Methods: retrospective review of women with stage IA1 squamous cervical cancer who underwent cold knife cone or loop electrosurgical excision procedure, between 1994 and 2015, at a gynecologic oncology center in Southern Brazil. Age at diagnosis, pre-conization findings, conization method, margin status, residual disease, recurrence and survival rates were collected and analyzed.  \nResults: 26 women diagnosed with stage IA1 squamous cervical cancer without lymphovascular space invasion underwent conservative management and had at least 12 months follow-up. The mean follow-up was 44.6 months. The mean age at diagnosis was 40.9 years. Median first intercourse occurred at age 16 years, 11.5% were nulliparous and 30.8% were current or past tobacco smokers. There was one Human immunodeficiency virus positive patient diagnosed with cervical intraepithelial neoplasia grade 2 at 30 months after surgery. However, there were no patients diagnosed with recurrent invasive cervical cancer and there were no deaths due to cervical cancer or other causes in the cohort.  \nConclusion: Excellent outcomes were noted in women with stage IA1 cervical cancer without lymphovascular space invasion and with negative margins who were managed conservatively, even in a developing country.  \nreceived  \nAugust 6, 2022  \naccepted after revision November 22, 2022  \nDOI [https://doi.org/](https://doi.org/)[ ](https://doi.org/)10.1055/s-0043-1769000 . ISSN 0100-7203.  \n© 2023 . Federação Brasileira de Ginecologia e Obstetrícia. All rights reserved.  \nThis is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited.([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/))  \nThieme Revinter Publicações Ltda., Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil  \n202 Conservative Treatment of Stage IA1 Cervical Carcinoma Without Lymphovascular Space Invasion Alberton et al.  \nResumo  \nPalavras-chave  \n► Neoplasias do colo do útero  \n► Conização  \n► Tratamento conservador  \n► Recorrência  \n► Carcinoma decélulas escamosas  \nObjetivo: Avaliar recidiva e seus fatores de risco em mulheres com câncer do colo do útero estádio IA1 sem invasão do espaço linfovascular tratadas conservadoramente. Métodos: Estudo de coorte retrospectivo de pacientes com câncer do colo do útero IA1 escamoso submetid","cbCaihZ2Xzrm7jLJ","https://ap.wps.com/l/cbCaihZ2Xzrm7jLJ","pdf",304510,"English","# Abstract\n# Purpose\n# Methods\n# Results\n# Conclusion\n# Introduction","[{\"question\":\"What was the purpose of the retrospective study?\",\"answer\":\"To evaluate recurrence rates and risk factors among women with stage IA1 cervical cancer without lymphovascular space invasion managed conservatively.\"},{\"question\":\"Which treatment approaches were included in the study methods?\",\"answer\":\"Women with stage IA1 squamous cervical cancer treated with cold knife cone or loop electrosurgical excision between 1994 and 2015 were included.\"},{\"question\":\"What were the main outcomes regarding recurrence and mortality?\",\"answer\":\"No patients were diagnosed with recurrent invasive cervical cancer, and there were no deaths due to cervical cancer or other causes in the cohort.\"}]","Conservative Treatment of Stage IA1 Cervical Carcinoma Without Lymphovascular Space Invasion - A 20-year Retrospective Study in Brazil | PDF",1790258499,15]