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Multidisciplinary experts reviewed the literature, graded evidence strength, and used UK-wide consensus voting by 48 pancreatic specialists. 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E. , Hopper, A. D. , Leeds, J. S. , Roberts, K. J. , McGeeney, L. , Duggan, S. N. , & Kumar, R. (2021) . Consensus for the management of pancreatic exocrine insufficiency: UK practical guidelines. BMJ Open  \nGastroenterology, 8(1), Article e000643 . [https://doi.org/10.1136/bmjgast-2021-000643](https://doi.org/10.1136/bmjgast-2021-000643)  \nPublished in:  \nBMJ Open Gastroenterology  \nDocument Version:  \nPublisher's PDF, also known as Version of record  \nQueen's University Belfast-Research Portal:  \nLink to publication record in Queen's University Belfast Research Portal  \nPublisher rights  \nCopyright 2021 The Authors.  \nThis is an open access article published under a Creative Commons Attribution-NonCommercial License  \n([https://creativecommons.org/licenses/by-nc/4.0/](https://creativecommons.org/licenses/by-nc/4.0/)), which permits use, distribution and reproduction for non-commercial purposes, provided the author and source are cited.  \nGeneral rights  \nCopyright for the publications made accessible via the Queen's University Belfast Research Portal is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights.  \nTake down policy  \nThe Research Portal is Queen's institutional repository that provides access to Queen's research output. Every effort has been made to ensure that content in the Research Portal does not infringe any person's rights, or applicable UK laws. If you discover content in the Research Portal that you believe breaches copyright or violates any law, [please contact openaccess@qub.ac.uk](please contact openaccess@qub.ac.uk).  \nOpen Access  \nThis research has been made openly available by Queen's academics and its Open Research team. We would love to hear how access to this research benefits you.– Share your feedback with us: [http://go.qub.ac.uk/oa-feedback](http://go.qub.ac.uk/oa-feedback)  \nDownload date:05 . Oct. 2026  \nPancreatic disease  \nConsensus for the management of pancreatic exocrine insufficiency: UK practical guidelines  \nMary E Phillips  ,1 Andrew D Hopper,2 John S Leeds  ,3 Keith J Roberts  ,4 Laura McGeeney,5 Sinead N Duggan,6 Rajesh Kumar7  \nTo cite: Phillips ME, Hopper AD, Leeds JS, et al. Consensus for the management of pancreatic exocrine insufficiency: UK practical guidelines. BMJ Open Gastro 2021;8:e000643 . doi:10 . 1136/ bmjgast-2021-000643  \n► Additional supplemental material is published online only. To view, please visit the journal online ([http://dx.doi](http://dx.doi). org/10.1136/bmjgast-2021- 000643) .  \nReceived 9 March 2021 Accepted 8 May 2021  \n© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.  \nFor numbered affiliations see end of article.  \nCorrespondence to  \nMary E Phillips;  \n[mary.phillips1@nhs.net](mary.phillips1@nhs.net)  \nABSTRACT  \nIntroduction Pancreatic exocrine insufficiency is a finding in many conditions, predominantly affecting those with chronic pancreatitis, pancreatic cancer and acute necrotising pancreatitis. Patients with pancreatic exocrine insufficiency can experience gastrointestinal symptoms, maldigestion, malnutrition and adverse effects on quality of life and even survival.  \nThere is a need for readily accessible, pragmatic advice for healthcare professionals on the management of pancreatic exocrine insufficiency.  \nMethods and analysis A review of the literature was conducted by a multidisciplinary panel of experts in pancreatology, and recommendations for clinical practice were produced and the strength of the evidence graded. Consensus voting by 48 pancreatic specialists from across the UK took place at the 2019 Annual Meeting of the Pancreatic Society of Great Britain and Ireland annual scientific meeting.  \n","cbCaifOzFk6ovaP2","https://ap.wps.com/l/cbCaifOzFk6ovaP2","pdf",1113827,"English","# Abstract\n## Introduction\n## Methods and analysis\n## Results\n## Clinical background (PEI presentation and treatment)","[{\"question\":\"What conditions are mainly associated with pancreatic exocrine insufficiency (PEI)?\",\"answer\":\"PEI is described as occurring in many conditions, predominantly in chronic pancreatitis, pancreatic cancer, and acute necrotising pancreatitis.\"},{\"question\":\"What is the primary treatment highlighted for PEI?\",\"answer\":\"Pancreatic enzyme replacement therapy (PERT) is presented as the cornerstone of treatment, linked to improved survival and quality of life.\"},{\"question\":\"What topics do the UK practical guidelines address?\",\"answer\":\"The recommendations cover diagnosis, initial management, patient education, and long-term follow-up, with all recommendations achieving over 85% consensus.\"}]","Consensus for the management of pancreatic exocrine insufficiency: UK practical guidelines | PDF",1791231233,76]