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Chronic diseases such as heart failure, chronic kidney disease, respiratory disorders, and diabetes impose growing health and economic burdens, and optimal care requires more than disease-specific therapy. Sarcopenia—age-related muscle loss with impaired strength and/or performance—interacts bidirectionally with chronic illness through inflammation, insulin resistance, neurohormonal activation, immobility, and nutritional deficits. Yet real-world screening is often insufficient due to low awareness, misconceptions, and unclear pathways. The article highlights AWGS guidance, practical screening tools, exercise and nutrition strategies, and emerging pharmacologic options to support healthier longevity.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/connecting-the-dots-sarcopenias-roles-on-chronic-condition-management-toward-healthy-aging/436256/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/connecting-the-dots-sarcopenias-roles-on-chronic-condition-management-toward-healthy-aging/436256.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is sarcopenia important in managing chronic conditions for healthy aging?","Question",{"text":113,"@type":114},"Sarcopenia bidirectionally interacts with common chronic disease pathophysiology. It worsens disease severity and contributes to adverse outcomes, while chronic illness accelerates muscle loss through inflammation, immobility, and nutritional deficits.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What are common reasons sarcopenia screening and assessment are not well performed in real-world practice?",{"text":118,"@type":114},"The article notes unawareness, misconceptions that sarcopenia is irremediable, and a lack of clear screening or management pathways.",{"name":120,"@type":111,"acceptedAnswer":121},"What practical approaches does the article discuss for sarcopenia management?",{"text":122,"@type":114},"It emphasizes integrating sarcopenia into chronic care using simple low-cost screening tools such as handgrip strength and chair-rise tests. Management centers on resistance exercise, protein-focused nutrition optimization, oral nutritional supplements when needed, and emerging pharmacologic options in early research.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},436256,1790773610,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":24,"preview_page_count":4},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","J Chin MedAssoc  \nEditorial  \nConnecting the dots: Sarcopenia’s roles on chronic condition management toward healthy aging  \nLiang-Kung Chena,b,c,*  \naCenter for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; bCenter for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; cTaipei Municipal Gan-Dau Hospital (Managed by Taipei Veterans General Hospital), Taipei, Taiwan, ROC  \nAging is a complex process that involves the disruption of homeostasis, reduced physiological reserve, decreased organ function, declined physical and cognitive abilities, increased morbidity or multimorbidity, and heightened social vulnerability, all of which are interconnected and collectively lead to adverse health outcomes over time.1 Given these attributes, rapid population aging in most Asian countries presents a distinct global challenge, with the potential to progressively reshape the world. Along with the phenomenon of rapid population aging, chronic conditions like heart failure, chronic kidney disease, chronic respiratory diseases, and diabetes mellitus resulting in heavy health and economic costs, projected to rise globally. Optimal management of these conditions goes beyond disease-specific therapies and requires a holistic approach that includes patients’ functional abilities and quality of life, necessitating the addressal of underrecognized issues like sarcopenia and related muscle health in chronic condition management.2,3  \nSarcopenia, defined as age-related muscle loss with impaired strength and/or physical performance, exerts profound adverse impacts on patient outcomes.4 Common age-related disease pathophysiology and sarcopenia pathobiology directly interact, with inflammation, insulin resistance, neurohormonal activation, immobility, and nutritional deficits in chronic illness driving catabolic muscle loss, and sarcopenia exacerbating disease severity through effects such as diminished respiratory muscle function in chronic obstructive pulmonary disease, reduced peripheral oxygen extraction in heart failure, and physical inactivity across conditions. The integral role of sarcopenia in chronic disease prognosis, underscored by its two-way interplay, is often overlooked in real-world practice. Although highly prevalent in older adults with disabling or wasting conditions, sarcopenia screening and assessment is not well performed in the real-world practice.5 Reasons may include unawareness, themisconception it is irremediable, and lack of clear screening/ management pathways. In an effort to enhance the recognition, evaluation, diagnosis, and treatment of sarcopenia, the Asian Working Group for Sarcopenia (AWGS) issued a consensus  \n* Address correspondence. Liang-Kung Chen, Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, 201, Section 2, Shi-Pai Road, Taipei112, Taiwan, ROC. E-mail address: [lkchen2@vghtpe.gov.tw](lkchen2@vghtpe.gov.tw) (L.-K. Chen). Conflicts of interest: Dr Liang-Kung Chen, an editorial board member at Journal of the Chinese Medical Association, had no role in the peer review process of or decision to publish this article.  \nJournal of Chinese Medical Association. (2024) 87: 3-4.  \nReceived date: November 14, 2023. Accepted date: November 15, 2023.  \ndoi: 10. 1097/JCMA.0000000000001027  \nCopyright © 2023, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4.0/](by-nc-nd/4.0/))  \nrecommendation in 2019.4 AWGS proposed distinct diagnostic algorithms for use in community health care and hospital settings, operationally defining “possible sarcopenia”to necessitate straightforward diagnostic efforts. Furthermore, AWGS advocated for the integration of sarcopenia into chronic condition management, with the aim of formulating a personalized and compreh","cbCaiobDkJpd6ZGf","https://ap.wps.com/l/cbCaiobDkJpd6ZGf","pdf",260411,"English","# Editorial\n## Sarcopenia and chronic disease interplay\n## Barriers to real-world screening and management\n## AWGS guidance and diagnostic algorithms\n## Practical screening tools\n## Core management: exercise, nutrition, and emerging pharmacologic options\n## Future directions for research and implementation","[{\"question\":\"Why is sarcopenia important in managing chronic conditions for healthy aging?\",\"answer\":\"Sarcopenia bidirectionally interacts with common chronic disease pathophysiology. It worsens disease severity and contributes to adverse outcomes, while chronic illness accelerates muscle loss through inflammation, immobility, and nutritional deficits.\"},{\"question\":\"What are common reasons sarcopenia screening and assessment are not well performed in real-world practice?\",\"answer\":\"The article notes unawareness, misconceptions that sarcopenia is irremediable, and a lack of clear screening or management pathways.\"},{\"question\":\"What practical approaches does the article discuss for sarcopenia management?\",\"answer\":\"It emphasizes integrating sarcopenia into chronic care using simple low-cost screening tools such as handgrip strength and chair-rise tests. Management centers on resistance exercise, protein-focused nutrition optimization, oral nutritional supplements when needed, and emerging pharmacologic options in early research.\"}]","Connecting the dots: Sarcopenia’s roles on chronic condition management toward healthy aging | PDF",1790677358]