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This report describes a 56-year-old male with a congenital lumbosacral meningocele that transformed into epithelioid angiosarcoma. The case coexisted with multiple spinal anomalies, including tethered cord and diastematomyelia. After admission and diagnostic workup, surgery was performed. Recurrence occurred 3 months postoperatively and was managed with radiotherapy and targeted therapy. Follow-up MRI showed regression, but the patient died 1 year after surgery, emphasizing vigilance and early biopsy for chronically untreated lesions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/congenital-lumbosacral-meningocele-with-malignant-transformation-to-epithelioid-angiosarcoma-a-case-report-of-complex-spinal-anomalies/415667/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/congenital-lumbosacral-meningocele-with-malignant-transformation-to-epithelioid-angiosarcoma-a-case-report-of-complex-spinal-anomalies/415667.png","ImageObject",300,407,{"name":92,"@type":93},"วิน","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What condition was described in the reported patient?","Question",{"text":112,"@type":113},"A 56-year-old male had a congenital lumbosacral meningocele with malignant transformation into epithelioid angiosarcoma, accompanied by additional spinal anomalies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which spinal anomalies were documented alongside the meningocele?",{"text":117,"@type":113},"Imaging described tethered cord syndrome spanning L2-S2 and diastematomyelia, including an osseocartilaginous septum, as well as other dysraphism-related findings.",{"name":119,"@type":110,"acceptedAnswer":120},"How was the recurrence treated and what was the outcome?",{"text":121,"@type":113},"Tumor recurrence occurred 3 months after surgery and was treated with combined radiotherapy and targeted therapy. Follow-up MRI showed regression, but the patient died 1 year after surgery.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},415667,1790798433,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},2336475104736,"https://ap-avatar.wpscdn.com/avatar/22000c4c5e0e5b17e70?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786591360781797222","Radiology Ca s e Reports 21 (2026) 1061 – 1066  \nAvailable online [at](at www.sciencedirect.com)[ www.sciencedirect.com](at www.sciencedirect.com)  \njournal [homepage:](homepage: www.elsevier.com/locate/radcr)[ www.elsevier.com/locate/radcr](homepage: www.elsevier.com/locate/radcr)  \n| Case Report\u003Cbr>Congenital lumbosacral meningocele with malignant transformation to epithelioidangiosarcoma: A case report of complex spinal anomalies ✩,✩✩\u003Cbr>Jie Wanga,b,\\#, Xuefeng Kanga,\\#, Guangxiang Chen, PhDa,∗\u003Cbr>a Department of Radiology, The Affiliated Hospital of Southwest Medical University, No.25, Taiping Road, Jiangyang District, Luzhou, 646000, Sichuan, China\u003Cbr>b Southwest Medical University, Luzhou, Sichuan, China |  |  |\n| --- | --- | --- |\n| a r t i c l e i n f o |  | a b s t r a c t |\n| Article history:\u003Cbr>Received 28 July 2025 Revised 11 November 2025 Accepted 17 November 2025 |  | Congenital neural tube defects rarely manifest in adulthood, and malignant transformation of meningocele is exceptionally rare. This report describes a rare case of a 56-year-old male with a congenital lumbosacral meningocele that underwent malignant transformation to epithelioid angiosarcoma, coexisting with multiple spinal anomalies, including tethered cord and diastematomyelia. Following admission and diagnostic workup, the patient underwent surgical intervention. Tumor recurrence occurred 3 months after surgery, and received combined radiotherapy and targeted therapy. Follow-up magnetic resonance imaging demonstrated regression of the recurrent tumor; however, the patient died 1 year after surgery. This case highlights that chronically untreated meningoceles may undergo malignant transformation due to persistent irritation, necessitating vigilance for lesion changes and early biopsy.\u003Cbr>© 2025 The Authors. Published by Elsevier Inc. on behalf of University of Washington.\u003Cbr>This is an open access article under the CC BY-NC-ND license\u003Cbr>([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/)) |\n| Keywords:\u003Cbr>Epithelioid angiosarcoma Meningocele\u003Cbr>Occult spinal dysraphism |  |  |\n\nIntroduction  \nNeural tube defects, which include meningoceles and myelomeningoceles, are the second most common type  \nof congenital disability after congenital heart defects [1] . Epithelioid angiosarcoma is a rare and highly aggressive endothelial cell malignant tumor with a high mortality rate that often arises in sun-exposed skin (60% of cases) and deep soft tissues [2] . Our literature search identified only a few  \n✩ Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.  \n✩✩ Acknowledgments: None.  \n∗ Corresponding author.  \nE-mail address: [cgx23ly2002@163.com](cgx23ly2002@163.com) (G. Chen).  \n\\# Jie Wang and Xuefeng Kang contributed equally to this work.  \n[https://doi.org/10.1016/j.radcr.2025.11.047](https://doi.org/10.1016/j.radcr.2025.11.047)  \n1930-0433/© 2025 The Authors. Published by Elsevier Inc. on behalf of University of Washington. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/))  \ncases of squamous cell carcinoma that had developed inan untreated myelomeningocele. However, no documented cases associated with epithelioid angiosarcoma have been reported to date. Here, we describe the case of an adult male who experienced this uncommon complication of a common congenital abnormality.  \nCase presentation  \nPatient history  \nA 56-year-old male presented with a congenital lumbosacral mass. Over the past year, he developed paroxysmal low back pain accompanied by numbness, weakness, and sensory diminution in the left lower limb. Conservative management with oral analgesics and physical therapy at an external institution failed to alleviate symptoms. Conseque","cbCaieVd0AlpPnAn","https://ap.wps.com/l/cbCaieVd0AlpPnAn","pdf",1273137,"English","# Case Report\n## Introduction\n## Case presentation\n### Patient history\n### Physical examination\n### Neurological examination\n### Imaging findings","[{\"question\":\"What condition was described in the reported patient?\",\"answer\":\"A 56-year-old male had a congenital lumbosacral meningocele with malignant transformation into epithelioid angiosarcoma, accompanied by additional spinal anomalies.\"},{\"question\":\"Which spinal anomalies were documented alongside the meningocele?\",\"answer\":\"Imaging described tethered cord syndrome spanning L2-S2 and diastematomyelia, including an osseocartilaginous septum, as well as other dysraphism-related findings.\"},{\"question\":\"How was the recurrence treated and what was the outcome?\",\"answer\":\"Tumor recurrence occurred 3 months after surgery and was treated with combined radiotherapy and targeted therapy. Follow-up MRI showed regression, but the patient died 1 year after surgery.\"}]","Congenital lumbosacral meningocele with malignant transformation to epithelioid angiosarcoma - A case report of complex spinal anomalies | PDF",1790602365,15]