[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-434634-105":59,"doc-detail-434634-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","computed-tomography-guided-irreversible-electroporation-for-a-pubic-bone-metastasis-a-technical-note-and-early-experience","Computed tomography-guided irreversible electroporation for a pubic bone metastasis - a technical note and early experience","","Bone metastases are common in advanced solid tumors and often require local control in addition to systemic therapy. Thermal ablation can be limited in anatomically complex, heat-sensitive sites, and irreversible electroporation (IRE) is non-thermal and has not been reported for bone metastases. This technical note describes computed tomography-guided IRE early experience for a pubic bone lesion near critical structures, highlighting feasibility, safety, and early oncologic efficacy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/computed-tomography-guided-irreversible-electroporation-for-a-pubic-bone-metastasis-a-technical-note-and-early-experience/434634/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/computed-tomography-guided-irreversible-electroporation-for-a-pubic-bone-metastasis-a-technical-note-and-early-experience/434634.png","ImageObject",300,407,{"name":92,"@type":93},"Melati","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why was thermal ablation unsuitable for the pubic bone metastasis in this case?","Question",{"text":112,"@type":113},"The lesion was in immediate proximity to the distal urethra and the anterior capsule of the pubic symphysis, making additional thermal ablation contraindicated due to risk to adjacent critical structures.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does irreversible electroporation (IRE) differ from thermal ablation?",{"text":117,"@type":113},"IRE is a non-thermal technique that delivers high-voltage electric pulses to induce apoptosis through permanent nanopores, preserving the extracellular matrix and reducing collateral injury compared with heat-based methods.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the authors report regarding feasibility and safety of CT-guided IRE?",{"text":121,"@type":113},"The procedure demonstrated technical feasibility and early oncologic efficacy, was technically successful and well-tolerated, with no peri-procedural complications and a complete metabolic response.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},434634,1791418024,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52,"preview_page_count":4},962085570644,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Copyright @ 2026 Author(s) -[Available online at dirjournal.org](Available online at dirjournal.org). Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.  \nTECHNICAL NOTE  \nComputed tomography-guided irreversible electroporation for a pubic bone metastasis: a technical note and early experience  \n Claudio Pusceddu1  \n Eliodoro Faiella2  \n Claudio Cau 1  \n Pierluigi Rinaldi1  \n Paolo Cossu3  \n Salvatore Marsico4  \n1Mater Olbia Hospital, Clinic of Radiology, Olbia, Italy  \n2Campus Bio Medico, Department of Radiology, Rome, Italy  \n3Mater Olbia Hospital, Clinic of Anesthesiology, Olbia, Italy  \n4Hospital del Mar, Clinic of Radiology, Barcelona, Spain  \nCorresponding author: Salvatore Marsico  \nE-mail: [salvatore.marsico@hotmail.it](salvatore.marsico@hotmail.it)  \nReceived 14 April 2025; revision requested 21 April 2025; last revision received 24 May 2025; accepted 22 June 2025.  \nEpub: 21.07.2025  \nPublication date: 02.01.2026  \nDOI: 10.4274/dir.2025.253402  \nABSTRACT  \nBone metastases are common in advanced solid tumors and often require local control strategies in addition to systemic therapy. Although thermal ablation is an established method for selected lesions, its use may be limited in anatomically complex or heat-sensitive locations. Irreversible electroporation, a non-thermal ablative technique widely used in visceral oncology, has not yet been reported for the treatment of bone metastases.  \nKEYWORDS  \nAblation, bone, interventional, metastases, oncology  \nB  \none metastases are a frequent and challenging complication of advanced malignancies, particularly in patients with breast, prostate, or lung cancer. These lesions often cause severe pain, impaired mobility, and pathological fractures, considerably reducing pa-  \ntients’ quality of life and functional autonomy. In the multidisciplinary management of such patients, local tumor control remains a key objective, especially for symptomatic, progressive, or weight-bearing lesions.  \nTraditional local therapies include external beam radiotherapy, surgical stabilization, and image-guided percutaneous ablation. Among these, thermal ablation methods–radiofrequencyablation (RFA), microwave ablation (MWA), and cryoablation–have been widely adopted due to their efficacy, minimal invasiveness, and rapid recovery profiles. These techniques are recommended by current practice guidelines for treating painful or oligometastatic bone lesions and are particularly useful when systemic options are exhausted or contraindicated. 1,2  \nHowever, thermal ablation has important limitations. It is contraindicated in anatomical regions where adjacent critical structures–such as nerves, vessels, hollow organs, or joint capsules–are susceptible to thermal injury. The anterior pelvic ring, sacrum, spine, and skull base are examples of areas where thermal techniques pose a substantial risk of collateral damage. Moreover, thermal spread can be difficult to control, especially in heterogeneous or poorly vascularized tissues such as bone.  \nIn this context, irreversible electroporation (IRE) represents a promising alternative. It is a non-thermal technique that induces apoptosis by delivering high-voltage electric pulses across cell membranes, creating permanent nanopores that disrupt cellular homeostasis.3,4 Its primary advantage lies in the preservation of the extracellular matrix and surrounding connective tissues. Unlike thermal energy, electrical fields do not denature collagen, elastin, or basement membranes, enabling tumor ablation near neurovascular bundles or urogenital organs with a reduced risk of collateral injury.5  \nIRE has already been validated in visceral oncology, particularly for pancreatic, hepatic, and renal tumors located in anatomically complex regions. Despite these promising applications, its use in the treatment of bone metastases has not been previously reported.  \nYou may cite this article as: Pusceddu C, Faiella","cbCaidviGQQEnE1q","https://ap.wps.com/l/cbCaidviGQQEnE1q","pdf",637592,"English","# Abstract\n# Keywords\n# Technique\n## Clinical case background\n## Imaging assessment\n## Rationale for IRE over thermal ablation\n# Main points","[{\"question\":\"Why was thermal ablation unsuitable for the pubic bone metastasis in this case?\",\"answer\":\"The lesion was in immediate proximity to the distal urethra and the anterior capsule of the pubic symphysis, making additional thermal ablation contraindicated due to risk to adjacent critical structures.\"},{\"question\":\"How does irreversible electroporation (IRE) differ from thermal ablation?\",\"answer\":\"IRE is a non-thermal technique that delivers high-voltage electric pulses to induce apoptosis through permanent nanopores, preserving the extracellular matrix and reducing collateral injury compared with heat-based methods.\"},{\"question\":\"What did the authors report regarding feasibility and safety of CT-guided IRE?\",\"answer\":\"The procedure demonstrated technical feasibility and early oncologic efficacy, was technically successful and well-tolerated, with no peri-procedural complications and a complete metabolic response.\"}]","Computed tomography-guided irreversible electroporation for a pubic bone metastasis - a technical note and early experience | PDF",1790670091]