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Open-access datasets were analyzed from TCGA, Xena, and TISCH using multiple algorithms and R packages. IL33 showed differential expression across cancers and strong single-cell enrichment in endothelial cells, aligning with features of the HCC immune microenvironment. IL33 expression correlated with patient survival and associated with stem cell division, angiogenesis, and inflammatory response.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comprehensively-analysis-of-il33-in-hepatocellular-carcinoma-prognosis-immune-microenvironment-and-biological-role/328286/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comprehensively-analysis-of-il33-in-hepatocellular-carcinoma-prognosis-immune-microenvironment-and-biological-role/328286.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What datasets and methods were used to study IL33 in HCC?","Question",{"text":112,"@type":113},"The study used open-access data from the Cancer Genome Atlas, Xena, and TISCH, applying different algorithms and R packages for multiple analyses.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Where is IL33 primarily expressed according to single-cell analysis?",{"text":117,"@type":113},"Single-cell analysis highlighted primary IL33 expression in endothelial cells, revealing correlations within the HCC microenvironment.",{"name":119,"@type":110,"acceptedAnswer":120},"How does IL33 relate to HCC prognosis and immune features?",{"text":121,"@type":113},"IL33 expression level correlated with patients’ survival and associated with immune microenvironment changes, including correlations with diverse immune cells and immune-related molecules.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328286,1790912281,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","DOI: 10. 1111/jcmm.18468  \nOR I G I NAL ART I C L E  \nComprehensively analysis of IL33 in hepatocellular carcinoma prognosis, immune microenvironment and biological role  \nLifang Wei1 | Ping He2 | Zhongqiu Tan3 | Cheng Lin3  | Zhongheng Wei3,4  \n1Health Management Center, The Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi, China  \n2School of Laboratory Medicine, Youjiang Medical University for Nationalities, Guangxi, China  \n3 Department of Oncology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China 4Guangxi Clinical Medical Research Center for Hepatobiliary Diseases, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China  \nCorrespondence  \nZhongheng Wei and Cheng Lin, Department of Oncology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China. Email: zhongheng_[wei@126.com](wei@126.com) and [linchengyj1984@163.com](linchengyj1984@163.com)  \nFunding information  \nNational Nature Science Foundation of China, Grant/Award Number: 82260532; the Scientific Project of High Talent of Affiliated Hospital of Youjiang Medical University for Nationalities, Grant/Award Number: R20196327  \nAbstract  \nIL33 plays an important role in cancer. However, the role of liver cancer remains unclear. Open-accessed data was obtained from the Cancer Genome Atlas, Xena, and TISCH databases. Different algorithms and R packages are used to perform various analyses. Here, in our comprehensive study on IL33 in HCC, we observed its differential expression across cancers, implicating its role in cancer development. The single-cell analysis highlighted its primary expression in endothelial cells, unveiling correlations within the HCC microenvironment. Also, the expression level of IL33 was correlated with patients survival, emphasizing its potential prognostic value. Biological enrichment analyses revealed associations with stem cell division, angiogenesis, and inflammatory response. IL33's impact on the immune microenvironment showcased correlations with diverse immune cells. Genomic features and drug sensitivity analyses provided insights into IL33's broader implications. In a pan-cancer context, IL33 emerged as a potential tumour-inhibitor, influencing immune-related molecules. This study significantly advances our understanding of IL33 in cancer biology. IL33 exhibited differential expression across cancers, particularly in endothelial cells within the HCC microenvironment. IL33 is correlated with the survival of HCC patients, indicating potential prognostic value and highlighting its broader implications in cancer biology.  \nK E Y WO R D S  \nIL33, immune, liver cancer, microenvironment, prognosis  \n1 | INTRODUCTION  \nLiver cancer, particularly hepatocellular carcinoma (HCC), is a common malignancy worldwide.1,2 Its development is often associated with prolonged liver diseases, such as chronic hepatitis (especially hepatitis B and C), alcoholic liver disease or non-alcoholic fatty liver disease.3 Due to the lack of distinct early symptoms, many patients are diagnosed at advanced stages, complicating treatment and adversely  \naffecting prognosis. The treatment options for liver cancer are varied, including surgical resection, radiation therapy, chemotherapy and the emerging targeted and immunotherapies.4 However, the complexity and drug resistance of liver cancer often limit the effectiveness of these treatments. Consequently, researchers are seeking more effective treatment strategies to improve patient survival rates and quality of life. Moreover, early detection is crucial for successful treatment of liver cancer.5 Recent advances have been made in early diagnosis and  \nLifang Wei and Ping He contributed equally to this study.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original ","cbCainAgPzC7OECE","https://ap.wps.com/l/cbCainAgPzC7OECE","pdf",21989944,12,"English","# Abstract\n# Introduction\n## Background: liver cancer and HCC\n## Biology of IL-33 and immune regulation","[{\"question\":\"What datasets and methods were used to study IL33 in HCC?\",\"answer\":\"The study used open-access data from the Cancer Genome Atlas, Xena, and TISCH, applying different algorithms and R packages for multiple analyses.\"},{\"question\":\"Where is IL33 primarily expressed according to single-cell analysis?\",\"answer\":\"Single-cell analysis highlighted primary IL33 expression in endothelial cells, revealing correlations within the HCC microenvironment.\"},{\"question\":\"How does IL33 relate to HCC prognosis and immune features?\",\"answer\":\"IL33 expression level correlated with patients’ survival and associated with immune microenvironment changes, including correlations with diverse immune cells and immune-related molecules.\"}]","Comprehensively analysis of IL33 in hepatocellular carcinoma prognosis, immune microenvironment and biological role | PDF",1789979179]