[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-379858-105":3,"detail-sidebar-cat-0-en-105":80,"doc-detail-379858-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","comprehensive-review-on-endoscopic-ultrasound-guided-tissue-acquisition-techniques-for-solid-pancreatic-tumor","Comprehensive review on endoscopic ultrasound-guided tissue acquisition techniques for solid pancreatic tumor","","Pancreatic ductal adenocarcinoma is projected to become a leading cause of cancer-related mortality, creating a need for clear histological diagnosis to guide treatment while minimizing patient burden. Endoscopic ultrasound (EUS)-guided tissue acquisition (TA) is described as suitable because it does not worsen cancer-specific prognosis, even for lesions at needle-tract seeding risk. Fine-needle biopsy (FNB) is increasingly replacing fine-needle aspiration (FNA) for pancreatic cancer, though FNA may remain necessary when FNB needles cannot access small, hard lesions. The review discusses updated EUS-TA techniques and specimen adequacy, focusing on needle caliber, negative pressure, and puncture methods.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/comprehensive-review-on-endoscopic-ultrasound-guided-tissue-acquisition-techniques-for-solid-pancreatic-tumor/379858/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/comprehensive-review-on-endoscopic-ultrasound-guided-tissue-acquisition-techniques-for-solid-pancreatic-tumor/379858.png","ImageObject",300,407,{"name":42,"@type":43},"Eliana","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-28","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":26},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"Why is endoscopic ultrasound-guided tissue acquisition important in pancreatic cancer?","Question",{"text":62,"@type":63},"It supports histological diagnosis needed to plan treatment and is commonly used in borderline-resectable and metastatic settings requiring neoadjuvant or palliative therapy.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How do EUS-FNB and EUS-FNA differ in practice?",{"text":67,"@type":63},"EUS-FNB is rapidly replacing EUS-FNA for pancreatic cancer, but EUS-FNA may still be required when the FNB needle cannot penetrate small hard lesions.",{"name":69,"@type":60,"acceptedAnswer":70},"What technical factors are discussed to improve specimen adequacy in EUS-TA?",{"text":71,"@type":63},"The review highlights technical aspects such as needle caliber, negative pressure, and puncture methods, including strategies to obtain adequate tissue.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},379858,1790570881,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":26,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2023 March 28; 29(12): 1863-1874  \nDOI: 10.3748/wjg.v29.i12.1863 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nMINIREVIEWS  \nComprehensive review on endoscopic ultrasound-guided tissue acquisition techniques for solid pancreatic tumor  \nSakue Masuda, Kazuya Koizumi, Kento Shionoya, Ryuhei Jinushi, Makomo Makazu, Takashi Nishino, Karen Kimura, Chihiro Sumida, Jun Kubota, Chikamasa Ichita, Akiko Sasaki, Masahiro Kobayashi, Makoto Kako, Uojima Haruki  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): 0  \nGrade C (Good): C, C, C  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Kaneko J, Japan; Tan B, China  \nReceived: December 27, 2022  \nPeer-review started: December 27, 2022  \nFirst decision: January 22, 2023  \nRevised: February 2, 2023  \nAccepted: March 15, 2023  \nArticle in press: March 15, 2023  \nPublished online: March 28, 2023  \nSakue Masuda, Kazuya Koizumi, Kento Shionoya, Ryuhei Jinushi, Makomo Makazu, Takashi Nishino, Karen Kimura, Chihiro Sumida, Jun Kubota, Chikamasa Ichita, Akiko Sasaki, Masahiro Kobayashi, Makoto Kako, Department of Gastroenterology, Shonan Kamakura General Hospital, Kanagawa 247-8533, Japan  \nUojima Haruki, Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Kanagawa 252-0375, Japan  \nCorresponding author: Sakue Masuda, MD, Chief Doctor, Department of Gastroenterology, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura, Kanagawa 247-8533, Japan.  \n[sakue.masuda@tokushukai.jp](sakue.masuda@tokushukai.jp)  \nAbstract  \nPancreatic ductal adenocarcinoma is speculated to become the second leading cause of cancer-related mortality by 2030, a high mortality rate considering the number of cases. Surgery and chemotherapy are the main treatment options, but they are burdensome for patients. A clear histological diagnosis is needed to determine a treatment plan, and endoscopic ultrasound (EUS)-guided tissue acquisition (TA) is a suitable technique that does not worsen the cancer-specific prognosis even for lesions at risk of needle tract seeding. With the development of personalized medicine and precision treatment, there has been an increasing demand to increase cell counts and collect specimens while preserving tissue structure, leading to the development of the fine-needle biopsy (FNB) needle. EUS-FNB is rapidly replacing EUS-guided fine-needle aspiration (FNA) as the procedure of choice for EUS-TA of pancreatic cancer. However, EUS-FNA is sometimes necessary where the FNB needle cannot penetrate small hard lesions, so it is important clinicians are familiar with both. Given these recent developments, we present an up-to-date review of the role of EUS-TA in pancreatic cancer. Particularly, technical aspects, such as needle caliber, negative pressure, and puncture methods, for obtaining an adequate specimen in EUS-TA are discussed.  \nKey Words: Endoscopic ultrasound-guided fine needle biopsy; Endoscopic ultrasoundguided tissue acquisition; Personalized medicine; Genomic profiling test; Pancreatic cancer; Puncture procedure  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 1863 March 28, 2023  Volume 29  Issue 12   \nMasuda S et al. Endoscopic ultrasound-guided tissue acquisition techniques  \n©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Endoscopic ultrasound (EUS)-guided tissue acquisition (TA) began in 1992 as EUS-guided fineneedle aspiration (FNA) . Recently, with the development of personalized medicine and precision treatment, the fine-needle biopsy (FNB) needle was developed. EUS-FNB is rapidly replacin","cbCaiec6Rvgdqmhn","https://ap.wps.com/l/cbCaiec6Rvgdqmhn","pdf",1428655,13,"English","# Introduction\n## Clinical need for EUS-guided tissue acquisition\n# EUS-TA overview\n## EUS-FNA vs EUS-FNB\n# Technical considerations\n## Needle caliber and negative pressure\n## Puncture methods and specimen adequacy\n# Clinical implications\n## Role in borderline-resectable and metastatic disease\n## When FNA remains necessary","[{\"question\":\"Why is endoscopic ultrasound-guided tissue acquisition important in pancreatic cancer?\",\"answer\":\"It supports histological diagnosis needed to plan treatment and is commonly used in borderline-resectable and metastatic settings requiring neoadjuvant or palliative therapy.\"},{\"question\":\"How do EUS-FNB and EUS-FNA differ in practice?\",\"answer\":\"EUS-FNB is rapidly replacing EUS-FNA for pancreatic cancer, but EUS-FNA may still be required when the FNB needle cannot penetrate small hard lesions.\"},{\"question\":\"What technical factors are discussed to improve specimen adequacy in EUS-TA?\",\"answer\":\"The review highlights technical aspects such as needle caliber, negative pressure, and puncture methods, including strategies to obtain adequate tissue.\"}]","Comprehensive review on endoscopic ultrasound-guided tissue acquisition techniques for solid pancreatic tumor | PDF",1790237778,33]