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This retrospective cohort study enrolled 260 hospitalized cirrhosis patients from May 2022 to August 2023 and compared those receiving the nutritional management with usual care. 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BMCGastroenterology (2026) 26:6 [https://doi.org/10.1186/s12876-025-04520-8](https://doi.org/10.1186/s12876-025-04520-8)  \nBMC Gastroenterology  \nRESEARCH Open Access  \nComprehensive nutritional management incorporating home-based dietary consultation improves hepatic encephalopathy in cirrhotic patients:  \na retrospective cohort study  \nQing Zhao 1†, Jiangqiang Xiao2†, Qin Yin2, Yue Xu 1, Jiashu Yao 1, Xiaotian Chen 1, Ming Zhang2,3*† and Bo Gao 1*†  \nAbstract  \nBackground Few studies have clinically demonstrated the benefits of comprehensive nutritional management incorporating home-based dietary consultation in patients with cirrhosis. This study investigates whether such management can improve the prognosis of cirrhotic patients.  \nMethods This retrospective study included 260 cirrhosis patients hospitalized between May 2022 and August 2023. We compared baseline characteristics and adverse outcomes during follow-up between patients who received comprehensive nutritional management incorporating home-based dietary consultation (nutritional management group) and those who did not (usual care group) . Kaplan-Meire analysis was applied to compare the liver transplantfree survival rate and the cumulative overt hepatic encephalopathy (OHE)-free rate between groups. Univariate and multivariate Cox regression models were performed to identify clinical factors associated with prognosis.  \nResults The incidence of OHE was significantly lower in the comprehensive nutritional management group compared to the usual care group. Kaplan–Meier analysis demonstrated a considerably higher cumulative OHE-free rate in the nutritional management group (log-rank P = 0 . 001) . However, the two groups had no significant difference in liver transplant-free survival. Multivariate Cox regression analysis identified nutritional management (HR 0 . 326, 95% CI: 0 .150–0. 712, P = 0 . 005) and higher serum albumin levels (HR 0 . 917, 95% CI: 0 .855–0. 983, P = 0 . 015) as protective factors against OHE, whereas sarcopenia (HR 2 . 541, 95% CI: 1.297–4. 977, P = 0 . 007) and elevated serum ammonia  \n\n| †Qing Zhao and Jiangqiang Xiao have contributed equally to this work and share first authorship. |\n| --- |\n| †Ming Zhang and Bo Gao have contributed equally to this work and share co-corresponding authorship. |\n\n*Correspondence:  \nMing Zhang [mg0923@163.com](mg0923@163.com)[ ](mg0923@163.com)Bo Gao [michellenjglyy@163.com](michellenjglyy@163.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/l](vecommons.org/l)icenses/by-nc-nd/4.0/.  \nZhao et al. BMC Gastroenterology (2026) 26:6 Page 2 of 11  \nlevels (HR 1. 009, 95% CI: 1.000–1. 018, P = 0 . 043) were associated with increased risk. However, comprehensive nutritional management was not significantly associated with mortality in Cox multivariate analysis. Conclusions Implementing comprehensive nutritional management incorporating home-based dietary ","cbCaia5b5foC7Rcs","https://ap.wps.com/l/cbCaia5b5foC7Rcs","pdf",1472513,11,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction\n## Cirrhosis, complications, and malnutrition\n## Nutritional recommendations and dietary misconceptions","[{\"question\":\"What was the purpose of this study?\",\"answer\":\"To evaluate whether comprehensive nutritional management that incorporates home-based dietary consultation improves prognosis in cirrhotic patients, with emphasis on overt hepatic encephalopathy outcomes.\"},{\"question\":\"How were patients grouped and what outcomes were compared?\",\"answer\":\"The study retrospectively compared 260 cirrhosis patients receiving home-based dietary consultation-based nutritional management versus usual care, using Kaplan–Meier analyses for liver transplant-free survival and cumulative OHE-free rates, and Cox regression for prognostic factors.\"},{\"question\":\"What factors were associated with overt hepatic encephalopathy risk?\",\"answer\":\"Nutritional management and higher serum albumin levels were protective against OHE, while sarcopenia and elevated serum ammonia were associated with increased OHE risk.\"}]","Comprehensive nutritional management incorporating home-based dietary consultation improves hepatic encephalopathy in cirrhotic patients - a retrospective cohort study | PDF",1790749941,28]