[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-336260-105":59,"doc-detail-336260-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","comprehensive-insights-into-renal-perivascular-epithelioid-cell-neoplasms-from-molecular-mechanisms-to-clinical-practice","Comprehensive Insights Into Renal Perivascular Epithelioid Cell Neoplasms: From Molecular Mechanisms to Clinical Practice","","Perivascular epithelioid cell neoplasms (PEComas) are rare mesenchymal tumors found across multiple organs, with a higher prevalence in females. Characteristic dual expression of melanocytic and smooth muscle markers makes immunohistochemistry essential for diagnosis. Renal angiomyolipoma is a common PEComa variant, generally with favorable outcomes, while only a minority—particularly epithelioid subtypes—can behave malignantly. Renal PEComas often present as asymptomatic masses with nonspecific imaging. Diagnostic confirmation relies mainly on histopathology and immunohistochemical staining, while management options include surveillance, selective embolization, surgery, and drug-based therapies; no uniform protocol exists.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comprehensive-insights-into-renal-perivascular-epithelioid-cell-neoplasms-from-molecular-mechanisms-to-clinical-practice/336260/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comprehensive-insights-into-renal-perivascular-epithelioid-cell-neoplasms-from-molecular-mechanisms-to-clinical-practice/336260.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are perivascular epithelioid cell neoplasms (PEComas) and where do they occur?","Question",{"text":112,"@type":113},"PEComas are rare mesenchymal tissue tumors that can appear in kidneys, liver, lungs, pancreas, uterus, ovaries, and the gastrointestinal tract.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why is immunohistochemistry important in diagnosing renal PEComas?",{"text":117,"@type":113},"Renal PEComas characteristically express both melanocytic and smooth muscle markers, so immunohistochemical staining is vital for diagnostic confirmation.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment approaches are discussed for renal PEComas?",{"text":121,"@type":113},"Management strategies include active surveillance, selective arterial embolization, surgical procedures, and drug-based treatments, since a standardized treatment plan is not currently available.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},336260,1790112987,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review World J Oncol. 2024;15(3):372-381  \nComprehensive Insights Into Renal Perivascular Epithelioid Cell Neoplasms: From Molecular Mechanisms to  \nClinical Practice  \nBao Nan Donga, Hui Zhana, b, Ting Luana, Jian Song Wanga  \nAbstract  \nPerivascular epithelioid cell neoplasms (PEComas) are a rare category of mesenchymal tissue tumors, manifesting across various tissues and organs such as the kidneys, liver, lungs, pancreas, uterus, ovaries, and gastrointestinal tract. They predominantly affect females more than males. PEComas characteristically express both melanocytic and smooth muscle markers, making immunohistochemistry vital for their diagnosis. Renal angiomyolipoma (AML) represents a common variant of PEComas, typically marked by favorable prognoses. Nonetheless, only a small fraction of subtypes, especially epithelioidAML, possess the capacity to be malignant. Renal PEComas usually appear as asymptomatic masses accompanied by vague imaging characteristics. The main methods for diagnosis are histopathological analysis and the application of immunohistochemical stains. Presently, a uniform treatment plan for renal PEComas is absent. Strategies for management include active surveillance, selective arterial embolization, surgical procedures, and drug-based treatments. The focus of this review is on renal PEComas, shedding light on their pathogenesis, pathological characteristics, clinical presentations, diagnosis, and treatment modalities, and incorporating a clinical case study.  \nKeywords: Perivascular epithelioid cell neoplasms; Angiomyolipoma; Etiology; Immunohistochemistry; Therapeutics  \nIntroduction  \nPerivascular epithelioid cell neoplasms (PEComas) are an uncommon type of tumor. According to the 2020 WHO Classification of Soft Tissues and Bone Tumors, PEComas are described as mesenchymal neoplasms composed of perivas-  \nManuscript submitted December 15, 2023, accepted March 16, 2024  \nPublished online April 15, 2024  \naUrology Surgery Department, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China  \nbCorresponding Author: Hui Zhan, Urology Surgery Department, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yun  \nnan, China. Email: [zhanhui77@126.com](zhanhui77@126.com)  \ndoi: [https://doi.org/10.14740/wjon1794](https://doi.org/10.14740/wjon1794)  \ncular epithelioid cells (PECs) - distinctive epithelioid cells that are often closely associated with blood vessel walls and that express both melanocytic and smooth muscle markers [1] . PEComas can manifest in various body parts, includingthe kidneys, liver, lungs, pancreas, uterus, ovaries, and gastrointestinal tract, and exhibit a higher prevalence in women. Excluding organs linked to gender (like the uterus, uterine, prostate), the occurrence rate in women ranges from 1.6 to 5 times greater than in men, as reported by various institutions [1-4]. Diagnosis predominantly relies on histopathology, complemented by immunohistochemistry, which typically reveals melanocytic and smooth muscle markers. Currently, there is no standardized treatment protocol for PEComas, and the main therapeutic approach involves surgical resection and adjuvant drug therapy, with options like chemotherapy, tyrosine kinase inhibitors (TKIs), and the mechanistic target of rapamycin (mTOR) inhibitors.  \nThis review comprehensively examines renal PEComas, including their pathogenesis, pathological characteristics, clinical presentations, diagnosis, and treatment modalities. The latter section offers a succinct overview of PEComas, framed within a recent case involving a male patient diagnosed with renal PEComas at our institution.  \nPathogenesis  \nThe precise mechanisms underlying the pathogenesis of PEComas remain elusive. Considering molecular genetics, the emergence of this tumor may be associated with mutations in specific genes including tuberous sclerosis complex (TSC), TFE3, and TP53 .  \nTSC mutation  \nThe TSC, an autosomal domin","cbCaiuJbO3kOJW1j","https://ap.wps.com/l/cbCaiuJbO3kOJW1j","pdf",2402397,"English","# Abstract\n# Introduction\n# Pathogenesis\n## TSC mutation\n## MiT family","[{\"question\":\"What are perivascular epithelioid cell neoplasms (PEComas) and where do they occur?\",\"answer\":\"PEComas are rare mesenchymal tissue tumors that can appear in kidneys, liver, lungs, pancreas, uterus, ovaries, and the gastrointestinal tract.\"},{\"question\":\"Why is immunohistochemistry important in diagnosing renal PEComas?\",\"answer\":\"Renal PEComas characteristically express both melanocytic and smooth muscle markers, so immunohistochemical staining is vital for diagnostic confirmation.\"},{\"question\":\"What treatment approaches are discussed for renal PEComas?\",\"answer\":\"Management strategies include active surveillance, selective arterial embolization, surgical procedures, and drug-based treatments, since a standardized treatment plan is not currently available.\"}]","Comprehensive Insights Into Renal Perivascular Epithelioid Cell Neoplasms: From Molecular Mechanisms to Clinical Practice | PDF",1790014288,25]