[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-467312-105":3,"doc-detail-467312-en":81,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","comprehensive-effects-of-melatonin-supplementation-on-cardiometabolic-risk-factors-a-systematic-review-and-doseresponse-meta-analysis","Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors - A Systematic Review and Dose–Response Meta-Analysis","","There is no definitive consensus on how melatonin affects cardiometabolic risk factors (CMRFs). This systematic review and dose–response meta-analysis evaluated randomized controlled trials to examine melatonin’s impact on anthropometric, lipid, glycemic, inflammatory, oxidative, and liver function measures. A search across multiple databases identified 63 eligible trials up to October 2025. Results showed significant reductions in hip circumference, systolic blood pressure, fasting glucose, LDL-C, total cholesterol, CRP, malondialdehyde, TNF-α, IL-6, and alanine aminotransferase, plus increases in total antioxidant capacity and HDL-C.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/comprehensive-effects-of-melatonin-supplementation-on-cardiometabolic-risk-factors-a-systematic-review-and-doseresponse-meta-analysis/467312/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/comprehensive-effects-of-melatonin-supplementation-on-cardiometabolic-risk-factors-a-systematic-review-and-doseresponse-meta-analysis/467312.png","ImageObject",300,407,{"name":42,"@type":43},"pop out","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the study design and evidence base used to evaluate melatonin?","Question",{"text":63,"@type":64},"The study combined findings from randomized controlled trials in a systematic review and dose–response meta-analysis, using a database search that identified eligible trials published up to October 2025.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which cardiometabolic risk factors improved with melatonin supplementation?",{"text":68,"@type":64},"Melatonin significantly reduced hip circumference, systolic blood pressure, fasting blood glucose, LDL cholesterol, total cholesterol, CRP, malondialdehyde, TNF-α, IL-6, and alanine aminotransferase, and increased serum total antioxidant capacity and HDL cholesterol.",{"name":70,"@type":61,"acceptedAnswer":71},"Were there any cardiometabolic outcomes that did not change significantly?",{"text":72,"@type":64},"No significant effects were observed on body weight, waist circumference, body fat percentage, BMI, fasting insulin, HOMA-IR, hemoglobin A1c, triglycerides, diastolic blood pressure, aspartate aminotransferase, or gamma-glutamyl transferase.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},467312,1790815560,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":92,"language":93,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":94,"faqs":95,"seo_title":96,"seo_description":12,"update_tm":97,"read_time":98,"preview_page_count":4},962090760408,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45",7,"Systematic Review  \nComprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose–Response Meta-Analysis  \nShooka Mohammadi 1, Damoon Ashtary-Larky 2, *, Mahsa Erfanian-Salim 3, Navid Alaghemand 2,  \nMojtaba Yousefi 4, Pouyan Sanjari Pirayvatlou 5, Mohammadreza Mirkarimi 6, Sara Ayazian Mavi 7, Ilnaz Alavi 8, Yeganeh Ettehad 5, Milad Mehrbod 9, Omid Asbaghi 10, Katsuhiko Suzuki 11, * and Russel J. Reiter 12  \nAcademic Editor: Yongting Luo  \nReceived: 9 November 2025  \nRevised: 15 December 2025  \nAccepted: 17 December 2025  \nPublished: 31 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia; [shooka.mohammadi@gmail.com](shooka.mohammadi@gmail.com)  \n2 Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran; [n.alaghemand@gmail.com](n.alaghemand@gmail.com)  \n3 Department of Pediatric Cardiology, Children’s Medical Center, Tehran University of Medical Sciences, Tehran 1416753955, Iran; [merfaniansalim@gmail.com](merfaniansalim@gmail.com)  \n4 Department of Cardiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran; [mojtaba657@gmail.com](mojtaba657@gmail.com)  \n5 Department of Internal Medicine, Faculty of Medicine, Alborz University of Medical Sciences, Karaj 3149969415, Iran; [dr.pouyan.sanjari.p@gmail.com](dr.pouyan.sanjari.p@gmail.com) (P.S.P.); [yeganehettehad@gmail.com](yeganehettehad@gmail.com) (Y.E.)  \n6 Department of Pediatrics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran; [mirkarimi-smr@ajums.ac.ir](mirkarimi-smr@ajums.ac.ir)  \n7 Department of Community Medicine, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran; [sayazianm1979@gmail.com](sayazianm1979@gmail.com)  \n8 Division of Cardiovascular Medicine, School of Medicine, University of Louisville, Louisville, KY 40222, USA; [i0alav01@louisville.edu](i0alav01@louisville.edu)  \n9 Department of Internal Medicine, Mercy San Juan Medical Center, Carmichael, CA 95608, USA; [milad.mehrbod@commonspirit.org](milad.mehrbod@commonspirit.org)  \n10 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran; [omid.asbaghi@gmail.com](omid.asbaghi@gmail.com)  \n11 Faculty of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan  \n12 Department of Cell Systems and Anatomy, Long School of Medicine, UT Health San Antonio, San Antonio, TX 78229, USA; [reiter@uthscsa.edu](reiter@uthscsa.edu)  \n* Correspondence: [damoon_ashtary@yahoo.com](damoon_ashtary@yahoo.com) (D.A.-L.); [katsu.suzu@waseda.jp](katsu.suzu@waseda.jp) (K.S.)  \nAbstract  \nBackground/Objectives: There is no definitive consensus regarding the effects of melatonin on cardiometabolic risk factors (CMRFs) . This systematic review and dose–response meta-analysis of randomized controlled trials (RCTs) evaluated the impacts of melatonin supplementation on CMRFs, including anthropometric, lipid, glycemic, inflammatory, oxidative, and liver function parameters. Methods: A systematic search across multiple databases retrieved 63 eligible RCTs published up to October 2025 . Results: This random-effects meta-analysis indicated that melatonin supplementation significantly reduced hip circumference (weighted mean difference (WMD): −1.18 cm, 95% confidence interval (CI): −2.28, −0.08), systolic blood pressure (WMD: −2.34 mmHg, 95% CI: −4.13,−0.55), fasting blood glucose (WMD: −11.63 mg/dL, 95% CI: −19.16, −4.10), low-density lipoprotein cholesterol (WMD: −6.28 mg/dL, 95% CI: −10.53, −2.03), total cholesterol (WMD: −6.97 mg/dL, 95% CI: −12.20, −1.74), C-reactiv","cbCaidIPON35aiGi","https://ap.wps.com/l/cbCaidIPON35aiGi","pdf",14755138,40,"English","# Abstract\n# Introduction","[{\"question\":\"What was the study design and evidence base used to evaluate melatonin?\",\"answer\":\"The study combined findings from randomized controlled trials in a systematic review and dose–response meta-analysis, using a database search that identified eligible trials published up to October 2025.\"},{\"question\":\"Which cardiometabolic risk factors improved with melatonin supplementation?\",\"answer\":\"Melatonin significantly reduced hip circumference, systolic blood pressure, fasting blood glucose, LDL cholesterol, total cholesterol, CRP, malondialdehyde, TNF-α, IL-6, and alanine aminotransferase, and increased serum total antioxidant capacity and HDL cholesterol.\"},{\"question\":\"Were there any cardiometabolic outcomes that did not change significantly?\",\"answer\":\"No significant effects were observed on body weight, waist circumference, body fat percentage, BMI, fasting insulin, HOMA-IR, hemoglobin A1c, triglycerides, diastolic blood pressure, aspartate aminotransferase, or gamma-glutamyl transferase.\"}]","Comprehensive Effects of Melatonin Supplementation on Cardiometabolic Risk Factors - A Systematic Review and Dose–Response Meta-Analysis | PDF",1790772680,101,{"code":4,"msg":82,"data":100},[101,105,109,113,118,123,125,130,134,137,141],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},5,"Comic",60,"comic",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},6,"Technology",50,"technology",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":92,"slug":124},"healthcare",{"id":126,"doc_module":4,"doc_module_name":25,"category_name":127,"show_sort_weight":128,"slug":129},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":131,"show_sort_weight":132,"slug":133},"Religion & Spirituality",20,"religion-spirituality",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":135,"show_sort_weight":132,"slug":136},"World Cup","world-cup",{"id":138,"doc_module":4,"doc_module_name":25,"category_name":139,"show_sort_weight":138,"slug":140},10,"Lifestyle","lifestyle",{"id":142,"doc_module":4,"doc_module_name":25,"category_name":143,"show_sort_weight":114,"slug":144},19,"General","general"]