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Public datasets are limited, especially for Asian populations, motivating this study to build a dataset of 75 Asian bladder cancer cases with 112 whole-slide images. For each patient, the collection links whole-exome sequencing results to clinically significant frequently mutated genes, supporting exploration and development of improved diagnostic and therapeutic technologies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comprehensive-collection-of-whole-slide-images-and-genomic-profiles-for-patients-with-bladder-cancer-research/328265/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comprehensive-collection-of-whole-slide-images-and-genomic-profiles-for-patients-with-bladder-cancer-research/328265.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is a new bladder cancer genomic dataset needed?","Question",{"text":112,"@type":113},"Genomic mutation identification is time-consuming and labor-intensive, while publicly available datasets are scarce, particularly for Asian populations.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What does the dataset contain?",{"text":117,"@type":113},"It includes 75 Asian bladder cancer cases and 112 whole-slide images, with gene mutation information derived from whole-exome sequencing.",{"name":119,"@type":110,"acceptedAnswer":120},"How can the dataset support bladder cancer research and clinical work?",{"text":121,"@type":113},"It helps explore and develop novel diagnostic and therapeutic technologies by providing clinically significant frequently mutated genes associated with the pathology slides.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328265,1790342570,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","[www. nature.com/scientificdata](www. nature.com/scientificdata)  \noPeN  \nData DeSCRIPtoR  \nComprehensive Collection of Whole-Slide Images and Genomic Profiles for Patients with Bladder Cancer  \nPei-Hang Xu1,2,10, Tianqi Li2,3,4,10, Fengmei Qu5,10, Mingkang tian5, Jun Wang6,7,8, Hualei Gan2,3,4, DingweiYe1,2 ✉, Fei Ren9 ✉ &Yijun Shen1,2 ✉  \nBladder cancer is one of the leading causes of cancer-related mortality in the urinary system. Understanding genomic information is important in the treatment and prognosis of bladder cancer, but the current method used to identify mutations is time-consuming and labor-intensive. There are now many novel and convenient ways to predict cancerous genomics from pathological slides. However, the publicly available datasets are limited, especially for Asian populations. In this study, we developed a dataset consisting of 75 Asian cases of bladder cancers and 112 Whole-Slide Images with one to two images obtained for each patient. This dataset provides information on the most frequently and  \nclinically significant mutated genes derived by whole-exome sequencing in these patients. This dataset will facilitate exploration and development of novel diagnostic and therapeutic technologies for bladder cancer.  \nBackground & Summary  \nBladder cancer (BLCA) is one of the most common and fatal malignant tumors ofthe urinary system1. Bladder cancer genomics aims to understand the genetic basis of tumor cell proliferation and evolution of the cancer genome under mutation and selection by the environment within the body, as well as the immune system and therapeutic interventions2–5. In medicine, the main reasons for knowing the cumulative phenotypic consequences of somatically acquired genetic, genomic and epigenetic alterations in cancer cells are related to prevention, detection and treatment6,7. For example, the presence ofTP53 and ERCC1 mutations might influence the sensitivity of muscle-Invasive bladder cancer (MIBC) to chemotherapy8,9. Furthermore, FGFR3 mutations characterize a subgroup of bladder cancers with a good prognosis, and EGFR, OAS1 and MST1R mutations indicate sensitivity to immunotherapy10, 11. The ability to identify these genetic mutations has benefits in terms of treatment of bladder cancer.  \nTraditionally, acquisition of a cancerous genome requires tumor resection, quality control and sequencing or panel detection, which is time-consuming, labor-intensive and expensive12. Identification of the genomic features ofa tumor has significance for treatment and the prognosis13. Numerous studies have attempted to predict the genomic status of tumors from pathological sections or even images14. However, training such models typically requires a large amount of data, and publicly available datasets are scarce15. Most of the current studies are based on The Cancer Imaging Archive (TCIA)16 data and lack publicly available external cohorts for validation, which has a negative impact on the robustness and extensibility of the models. Meanwhile, The Cancer Genome  \n1 Department of Urology, fudan University Shanghai cancer center, Shanghai, china. 2 Department of Oncology, Shanghai Medical college, fudan University, Shanghai, china. 3 Department of Pathology, fudan University Shanghai cancer center, Shanghai, china. 4 Institute of Pathology, Fudan University, Shanghai, 200032, China. 5Jinfeng Laboratory, Chongqing, 401329, P. R. China. 6Department of Urology, SunYat-sen University Cancer Center, Guangzhou, china. 7State Key Laboratory of Oncology in Southern china, Guangzhou, china. 8State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, SunYat-sen University Cancer center, Guangzhou, china. 9State Key Lab of Processors, Institute of Computing Technology, CAS, Beijing, 100190, china. 10 These authors contributed equally: Pei-Hang Xu, Tianqi Li, Fengmei Qu. ✉ e-mail: [dwyelie@163.com](dwyelie@163.com);  \n[renfei@ict.ac.cn](renfei@ict.ac.cn); [yijunshen79","cbCailt8S3wq1dch","https://ap.wps.com/l/cbCailt8S3wq1dch","pdf",2041307,"English","# Background & Summary\n# Methods\n## Patients and ethical approval\n## Selection and preparation of specimens","[{\"question\":\"Why is a new bladder cancer genomic dataset needed?\",\"answer\":\"Genomic mutation identification is time-consuming and labor-intensive, while publicly available datasets are scarce, particularly for Asian populations.\"},{\"question\":\"What does the dataset contain?\",\"answer\":\"It includes 75 Asian bladder cancer cases and 112 whole-slide images, with gene mutation information derived from whole-exome sequencing.\"},{\"question\":\"How can the dataset support bladder cancer research and clinical work?\",\"answer\":\"It helps explore and develop novel diagnostic and therapeutic technologies by providing clinically significant frequently mutated genes associated with the pathology slides.\"}]","Comprehensive Collection of Whole-Slide Images and Genomic Profiles for Patients with Bladder Cancer - Research | PDF",1789979107]