[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-42499-en":3,"doc-seo-42499-105":30,"detail-sidebar-cat-0-en-105":92},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":21,"is_downloadable":21,"audit_status":21,"page_count":22,"language":23,"language_code":24,"site_id":25,"html_lang":24,"table_of_contents":26,"faqs":27,"seo_title":13,"seo_description":14,"update_tm":28,"read_time":29},42499,13056703019404,"Miles","https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0",7,"Healthcare","Comprehensive Clinical and Histological Evaluation of Bovine Hydroxyapatite Bone Graft With Polypropylene Membrane vs L-PRF","The study evaluates alveolar preservation after tooth extraction by comparing bovine hydroxyapatite bone graft covered with a polypropylene membrane (BHAG-PM) against leukocyte- and platelet-rich fibrin (L-PRF). The background addresses ridge height and width reduction that can compromise osseointegrated implant placement. The case-report approach applies extraction, graft placement, and standardized site treatment for both groups. Up to 24 months, clinical and histological results are satisfactory and comparable, supporting both methods for maintaining alveolar bone and enabling implant positioning.","ORIGINAL ARTICLE  \nComprehensive clinical and histological evaluation of bovine hydroxyapatite bone graft with polypropylene membrane versus leukocyte-and platelet-rich fibrin for alveolar preservation after tooth extraction  \nKarine C. LIMA 1, 2 , Maria E. BIZZOCA 3 *, Michele COVELLI 4 , Anderson C. DE OLIVEIRA 1 , Fabiano C. ZANARDO 1, 5 , Ricardo R. VECCHIATTI 1 , Jocelino L. SOARES 1 , Nunzio CIRULLI 6 , Stefania CANTORE 7 , Fábio F. SILVA 7, 8, 9  \n1Brazilian Dental Association, Nova Iguaçu, Brazil; 2Department of Dental Medicine, Federal Fluminense University, Rio de Janeiro, Brazil; 3Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy; 4Libera Università Mediterranea “G. Degennaro”, Casamassima, Bari, Italy; 5Faculty of Dentistry (FOUSP), University of Sao Paulo, São Paulo, Brazil; 6Private practitioner, Bari, Italy; 7Department of Precision Medicine, University of Campania Luigi Vanvitelli, Caserta, Italy; 8Oral Medicine, Oral Surgery and Implantology Unit (MedOralRes), Faculty of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain; 9ORALRES Group, Health Research Institute of Santiago de Compostela (FIDIS), Santiago de Compostela, Spain  \n*Corresponding author: Maria E. Bizzoca, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy. [E-mail: mariaeleonora.bizzoca@unifg.it](E-mail: mariaeleonora.bizzoca@unifg.it)  \nABSTRACT  \nBACKGROUND: Osseointegrated implant placement in the ideal prosthetic position necessitates a sufficient residual alveolar ridge. Tooth extraction and the subsequent healing process often lead to bony deformities, characterized by a reduction in alveolar ridge height and width, resulting in unfavorable ridge architecture for dental implant placement. Several materials, including allografts, alloplastics, xenografts, and autogenous bone, are commonly used to address these concerns. In this context, leucocyte-and platelet-rich fibrin (L-PRF) emerges as a promising solution.  \nMETHODS: This case report aims to compare the clinical and histological efficacy of bovine hydroxyapatite bone graft covered with polypropylene membrane (BHAG-PM) and leucocyte-and platelet-rich fibrin (L-PRF) in preserving dental alveoli following tooth extraction. Extraction, graft placement in the alveoli, and the anterior border between extracted elements were performed for both treatment groups.  \nRESULTS: Up to 24 months of follow-up revealed satisfactory and comparable clinical and histological outcomes. These results suggest that both BHAG-PM and L-PRF effectively promote alveolar preservation, paving the way for ideal implant placement.  \nCONCLUSIONS: In general, bone-substitute materials are effective in reducing alveolar changes after tooth extraction. Xenograft materials should be considered as among the best ofthe available grafting materials for alveolar preservation after tooth extraction. Both techniques effectively preserve the alveolar bone and facilitate the placement of osseointegrated implants in ideal positions, paving the way for successful oral rehabilitation.  \n(Cite this article as: Lima KC, Bizzoca ME, Covelli M, De Oliveira AC, Zanardo FC, Vecchiatti RR, et al. Comprehensive clinical and histological evaluation of bovine hydroxyapatite bone graft with polypropylene membrane versus leukocyte-and platelet-rich fibrin for alveolar preservation after tooth extraction. Minerva Dent Oral Sci 2024;73:279-86 . DOI: 10.23736/ S2724-6329.24.05016-2)  \nKey words: Bone regeneration; Osseointegration; Dental materials; Dental implants; Tooth fractures; Bone transplantation.  \nVol. 73-No. 5 MINERVA DENTAL AND ORAL SCIENCE 279  \nOsseoideailnteprgoratedsthetic implantposition pnceesmentsitatesina sthufeficient residual alveolar ridge. However, bone defects pose a significant challenge in achieving this goal.1 After tooth extraction, the alveolar ridge undergoes considerable remodeling, predominantly within the ","cbCaiqGo0ff90Dyf","https://ap.wps.com/l/cbCaiqGo0ff90Dyf","pdf",1179009,5,1,8,"English","en",105,"# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction and Rationale\n## Ridge remodeling after extraction\n## Bone grafting options and challenges\n## Comparison materials: BHAG-PM and L-PRF\n## Guided bone regeneration and barrier membranes","[{\"question\":\"Why does tooth extraction often affect future dental implant outcomes?\",\"answer\":\"After extraction, the alveolar ridge remodels and commonly loses height and width, which can lead to unfavorable ridge architecture and risk suboptimal implant placement or exposure.\"},{\"question\":\"What treatment comparison does the document evaluate?\",\"answer\":\"It compares bovine hydroxyapatite bone graft covered with a polypropylene membrane (BHAG-PM) versus leukocyte- and platelet-rich fibrin (L-PRF) for preserving dental alveoli after extraction.\"},{\"question\":\"What follow-up timeframe and overall findings are reported?\",\"answer\":\"The follow-up reaches up to 24 months, showing satisfactory and comparable clinical and histological outcomes for both BHAG-PM and L-PRF, supporting effective alveolar preservation for ideal implant placement.\"}]",1783353249,20,{"code":4,"msg":31,"data":32},"ok",{"site_id":25,"language":24,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":87,"head_meta":89,"extra_data":91,"updated_unix":28},"comprehensive-clinical-and-histological-evaluation-of-bovine-hydroxyapatite-bone-graft-with-polypropylene-membrane-vs-l-prf","",{"@graph":36,"@context":86},[37,54,69],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":21},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/healthcare/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/comprehensive-clinical-and-histological-evaluation-of-bovine-hydroxyapatite-bone-graft-with-polypropylene-membrane-vs-l-prf/42499/",4,{"url":52,"name":13,"@type":55,"author":56,"headline":13,"publisher":58,"fileFormat":61,"inLanguage":24,"description":14,"dateModified":62,"datePublished":63,"encodingFormat":61,"isAccessibleForFree":64,"interactionStatistic":65},"DigitalDocument",{"name":9,"@type":57},"Person",{"url":41,"name":59,"@type":60},"DocShare","Organization","application/pdf","2026-07-17","2026-07-06",true,{"@type":66,"interactionType":67,"userInteractionCount":20},"InteractionCounter",{"@type":68},"ViewAction",{"@type":70,"mainEntity":71},"FAQPage",[72,78,82],{"name":73,"@type":74,"acceptedAnswer":75},"Why does tooth extraction often affect future dental implant outcomes?","Question",{"text":76,"@type":77},"After extraction, the alveolar ridge remodels and commonly loses height and width, which can lead to unfavorable ridge architecture and risk suboptimal implant placement or exposure.","Answer",{"name":79,"@type":74,"acceptedAnswer":80},"What treatment comparison does the document evaluate?",{"text":81,"@type":77},"It compares bovine hydroxyapatite bone graft covered with a polypropylene membrane (BHAG-PM) versus leukocyte- and platelet-rich fibrin (L-PRF) for preserving dental alveoli after extraction.",{"name":83,"@type":74,"acceptedAnswer":84},"What follow-up timeframe and overall findings are reported?",{"text":85,"@type":77},"The follow-up reaches up to 24 months, showing satisfactory and comparable clinical and histological outcomes for both BHAG-PM and L-PRF, supporting effective alveolar preservation for ideal implant 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