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Methods: This study integrates large-scale transcriptomic and clinical data from public databases to evaluate NOX4 expression across pan-cancer cohorts. Survival, methylation, and correlation analyses assess diagnostic and prognostic value across cancer types, and expression-immune infiltration relationships are examined. Results: NOX4 is consistently upregulated in tumors vs. normal tissues, associates with worse overall survival in several cancers, and correlates with immune cell infiltration, suggesting tumor microenvironment modulation. Conclusions: NOX4 emerges as a multifaceted biomarker with diagnostic, prognostic, and immunomodulatory implications.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comprehensive-bioinformatics-analysis-of-nox4-as-a-biomarker-for-pan-cancer-prognosis-and-immune-infiltration-research-paper/327642/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comprehensive-bioinformatics-analysis-of-nox4-as-a-biomarker-for-pan-cancer-prognosis-and-immune-infiltration-research-paper/327642.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the study’s main goal regarding NOX4?","Question",{"text":112,"@type":113},"To investigate NOX4 across a wide range of cancer types and determine how NOX4 expression relates to prognosis and tumor immune infiltration.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which data and analyses are used to assess NOX4?",{"text":117,"@type":113},"Large-scale transcriptomic and clinical data from public databases are analyzed using survival analysis, methylation analysis, and correlation studies, along with immune infiltration assessment.",{"name":119,"@type":110,"acceptedAnswer":120},"What key findings connect NOX4 to cancer outcomes and the tumor immune microenvironment?",{"text":121,"@type":113},"NOX4 is upregulated in multiple cancers versus normal tissues, higher expression associates with poorer overall survival in several cancers, and NOX4 expression correlates with immune cell infiltration, indicating involvement in tumor microenvironment modulation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},327642,1790185048,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},4810365810221,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","[www.aging-us.com](www.aging-us.com) AGING 2024, Vol. 16, No. 8  \nResearch Paper  \nComprehensive bioinformatics analysis of NOX4 as a biomarker for pan-cancer prognosis and immune infiltration  \nYuying Liu1,*, Hua Huang2,*, Xijun Yang3,*, Danhe Huang1, Xiongwei Wang1, Mingyu Yuan1, Lianqing Hong1  \n1 Department of Pathology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated with Nanjing University of Chinese Medicine, Nanjing, China  \n2Tianjin Medical University, Tianjin, China  \n3 Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China  \n* Equal contribution and share first authorship  \nCorrespondence to: Lianqing Hong; email: [hnq1776@126.com](hnq1776@126.com), [https://orcid.org/0009-0004-1012-3570](https://orcid.org/0009-0004-1012-3570)  \n[Keywords:](Keywords: pan-cancer analysis)[ pan-cancer analysis](Keywords: pan-cancer analysis), bioinformatics, NADPH oxidase 4, tumor immune microenvironment, immune checkpoint  \nReceived: November 27, 2023 Accepted: March 26, 2024 Published: April 25, 2024  \nCopyright: © 2024 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nABSTRACT  \nBackground: NADPH oxidase 4 (NOX4) has been proven to be associated with the prognosis of tumors in multiple cancers and can serve as a potential immunotherapy target to provide new treatment options for various tumors. In this study, our aim is to conduct an in-depth investigation of NOX4 across a range of cancer types to determine the relationship between NOX4 and tumors.  \nMethods: Utilizing large-scale transcriptomic and clinical data from public databases, a systematic examination of NOX4 expression patterns was performed in pan-cancer cohorts. Survival analysis, methylation analysis, and correlation studies were employed to assess the diagnostic and prognostic significance of NOX4 in diverse cancer types. Additionally, an exploration of the relationship between NOX4 expression and immune infiltration across various tumors was conducted.  \nResults: The analyses unveiled a consistent upregulation of NOX4 expression in multiple cancer types relative to normal tissues, indicating its potential as a universal cancer biomarker. Elevated NOX4 expression significantly correlated with poor overall survival in several cancers. Furthermore, the study demonstrated a robust correlation between NOX4 expression and immune cell infiltration, signifying its involvement in the modulation of the tumor microenvironment.  \nConclusions: This study imparts valuable insights into the potential applications of NOX4 in cancer research, highlighting its significance as a multifaceted biomarker with diagnostic, prognostic, and immunomodulatory implications across diverse malignancies.  \nINTRODUCTION  \nCancer is a complex group of diseases and remains a major cause of human mortality globally. It continues to pose a significant global health challenge, necessitating urgent research efforts and solutions [1, 2] . The current central focus of cancer research is on identifying effective biomarkers to facilitate early  \ndiagnosis of cancer, predict patient prognosis, and select appropriate treatment strategies [3] .  \nNADPH oxidase 4 (NOX4) is one of the seven members of the Nox family (Nox1, Nox2, Nox3, Nox4, Nox5, Duox1, and Duox2), and Nox4 has been identified as one of the major sources of reactive oxygen species (ROS) . Increased generation of ROS has been implicated  \n7437  \nin the pathogenesis of various diseases such as cancer and cardiovascular disease [4] . NOX4 is widely expressed in many different tissues and has a wider range of biological functions. As a major endogenous ROS source, NOX4 is involved in regulating multiple cellular functions, including cell proliferation, migration, and death [5, 6] .","cbCaifKnI30uba0W","https://ap.wps.com/l/cbCaifKnI30uba0W","pdf",3109395,11,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction\n## Rationale and biomarker need","[{\"question\":\"What is the study’s main goal regarding NOX4?\",\"answer\":\"To investigate NOX4 across a wide range of cancer types and determine how NOX4 expression relates to prognosis and tumor immune infiltration.\"},{\"question\":\"Which data and analyses are used to assess NOX4?\",\"answer\":\"Large-scale transcriptomic and clinical data from public databases are analyzed using survival analysis, methylation analysis, and correlation studies, along with immune infiltration assessment.\"},{\"question\":\"What key findings connect NOX4 to cancer outcomes and the tumor immune microenvironment?\",\"answer\":\"NOX4 is upregulated in multiple cancers versus normal tissues, higher expression associates with poorer overall survival in several cancers, and NOX4 expression correlates with immune cell infiltration, indicating involvement in tumor microenvironment modulation.\"}]","Comprehensive bioinformatics analysis of NOX4 as a biomarker for pan-cancer prognosis and immune infiltration - Research paper | PDF",1789977709,28]