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This study performs pan-cancer bioinformatics by assessing HCMV pathway gene expression across 26 tumor types using TCGA and GTEx. Immune infiltration and tumor microenvironment patterns are evaluated, while Cox regression and machine learning identify prognostic genes and connect them to drug sensitivity. Results highlight widespread pathway expression, immune involvement, 23 key hub genes, and differential CaM/AC regulation, suggesting therapeutic relevance.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comprehensive-bioinformatics-analysis-of-human-cytomegalovirus-pathway-genes-in-pan-cancer/330851/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comprehensive-bioinformatics-analysis-of-human-cytomegalovirus-pathway-genes-in-pan-cancer/330851.png","ImageObject",300,407,{"name":92,"@type":93},"Violet","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the study address about HCMV in cancer?","Question",{"text":112,"@type":113},"It examines how HCMV pathway genes relate to cancer by clarifying their molecular mechanisms and potential impact on immune processes and tumor progression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which datasets and analyses are used to study HCMV pathway genes?",{"text":117,"@type":113},"The work analyzes gene expression across 26 cancer types using TCGA and GTEx, and applies immune infiltration/microenvironment assessment plus Cox regression and machine learning for prognostic and drug-sensitivity relationships.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings regarding key HCMV pathway genes?",{"text":121,"@type":113},"HCMV pathway genes show broad expression across cancers, immune infiltration reveals involvement in complex immune processes, and 23 key genes are identified as prognostic, enriched in chemotaxis and synaptic functions, with CaM up-regulated and AC down-regulated in many tumors.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330851,1789996597,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","Yan et al. Human Genomics (2024) 18:65 Human Genomics  \n[https://doi.org/10.1186/s40246-024-00633-5](https://doi.org/10.1186/s40246-024-00633-5)  \nRESEARCH Open Access  \nComprehensive bioinformatics analysis of human cytomegalovirus pathway genes in pan-cancer  \nTengyue Yan 1†, Xianwu Pang2†, Boying Liang3†, Qiuxia Meng4, Huilin Wei5, Wen Li6, Dahai Liu7* andYanling Hu 1,5*  \nAbstract  \nBackground Human cytomegalovirus (HCMV) is a herpesvirus that can infect various cell types and modulate host gene expression and immune response. It has been associated with the pathogenesis of various cancers, but its molecular mechanisms remain elusive.  \nMethods We comprehensively analyzed the expression of HCMV pathway genes across 26 cancer types using the Cancer Genome Atlas (TCGA) and The Genotype-Tissue Expression (GTEx) databases. We al so used bioinformatics tools to study immune invasion and tumor microenvironment in pan-cancer. Cox regression and machine learning were used to analyze prognostic genes and their relationship with drug sensitivity.  \nResults We found that HCMV pathway genes are widely expressed in various cancers. Immune infiltration and the tumor microenvironment revealed that HCMV is involved in complex immune processes. We obtained prognostic genes for 25 cancers and significantly found 23 key genes in the HCMV pathway, which are significantly enriched in cellular chemotaxis and synaptic function and may be involved in disease progression. Notably, CaM family genes were up-regulated and AC family genes were down-regulated in most tumors. These hub genes correlate with sensitivity or resistance to various drugs, suggesting their potential as therapeutic targets.  \nConclusions Our study has revealed the role of the HCMV pathway in various cancers and provided insights into its molecular mechanism and therapeutic significance. It is worth noting that the key genes of the HCMV pathway may open up new doors for cancer prevention and treatment.  \nKeywords Human cytomegalovirus pathway, Pan-cancer, Immune infiltration, Tumor mutation burden, Bioinformatics  \n†Tengyue Yan, Xianwu Pang and Boying Liang contributed equally to this work.  \n*Correspondence:  \nDahai Liu [seansean2014@126.com](seansean2014@126.com)[ ](seansean2014@126.com)Yanling Hu [huyanling@gxmu.edu.cn](huyanling@gxmu.edu.cn)  \n1Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning,  \nGuangxi 530021, China  \n2Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning 530028, China  \n3Department of Immunology, School of Basic Medical Sciences, Guangxi Medical University, Nanning, China  \n4School of Information and Managent, Guangxi Medical University, Nanning, China  \n5School of Institute of Life Sciences, Guangxi Medical University, Nanning, China  \n6Department of Biochemistry and Molecular Biology, School of Basic Medicine, Guangxi Medical University, Nanning, China  \n7School of Medicine, Foshan University, Foshan, Guangdong  \n528000, People’s Republic of China  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.o","cbCaif5FJWDY0G36","https://ap.wps.com/l/cbCaif5FJWDY0G36","pdf",9438962,17,"English","# Abstract\n# Background\n## Cancer burden and incidence trends\n## HCMV prevalence, transmission, and clinical course\n# Methods\n# Results\n# Conclusions","[{\"question\":\"What question does the study address about HCMV in cancer?\",\"answer\":\"It examines how HCMV pathway genes relate to cancer by clarifying their molecular mechanisms and potential impact on immune processes and tumor progression.\"},{\"question\":\"Which datasets and analyses are used to study HCMV pathway genes?\",\"answer\":\"The work analyzes gene expression across 26 cancer types using TCGA and GTEx, and applies immune infiltration/microenvironment assessment plus Cox regression and machine learning for prognostic and drug-sensitivity relationships.\"},{\"question\":\"What were the main findings regarding key HCMV pathway genes?\",\"answer\":\"HCMV pathway genes show broad expression across cancers, immune infiltration reveals involvement in complex immune processes, and 23 key genes are identified as prognostic, enriched in chemotaxis and synaptic functions, with CaM up-regulated and AC down-regulated in many tumors.\"}]","Comprehensive bioinformatics analysis of human cytomegalovirus pathway genes in pan-cancer | PDF",1789990490,43]