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Methods: Kaplan–Meier and COX analyses assessed survival associations, and Spearman correlations evaluated links between IDO1 and MSI, DNMTs, TMB, MMR genes, immune checkpoint biomarkers, alongside immunohistochemistry and qRT-PCR expression profiling. Results: IDO1 displayed abnormal expression and prognostic relevance across multiple cancers, with associations spanning TMB, MSI, MMR, drug sensitivity, immune infiltration, and tumor immune microenvironment. Conclusion: Findings provide a theoretical basis supporting improved clinical treatment strategies targeting IDO1.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comprehensive-analysis-of-the-prognostic-value-and-immunological-role-of-ido1-gene-in-pan-cancer/330344/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comprehensive-analysis-of-the-prognostic-value-and-immunological-role-of-ido1-gene-in-pan-cancer/330344.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main objective of this study?","Question",{"text":112,"@type":113},"To assess the prognostic value and immunological role of the IDO1 gene across pan-cancer, given limited prior characterization.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What methods were used to analyze IDO1 and patient outcomes?",{"text":117,"@type":113},"Kaplan–Meier and COX analyses were applied for survival analysis, supported by Spearman correlation analyses with genomic and immune biomarkers.",{"name":119,"@type":110,"acceptedAnswer":120},"What major associations did the study find for IDO1?",{"text":121,"@type":113},"IDO1 showed abnormal expression and related prognosis in multiple cancers, and its aberrant expression correlated with TMB, MSI, MMR, drug sensitivity, immune cell infiltration, and the tumor immune microenvironment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330344,1790173626,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Lin etal. European Journal  \nEuropean Journal of Medical Research (2024) 29:206  \n[https://doi.org/10.1186/s40001-024-01766-y](https://doi.org/10.1186/s40001-024-01766-y of Medical Research)[ of Medical Research](https://doi.org/10.1186/s40001-024-01766-y of Medical Research)  \n RESEARCH Open Access  \nComprehensive analysis of the prognostic value and immunological role of IDO1 gene in pan-cancer  \nKaili Lin1†, Yongfeng Wang2,3,4,5†, Fangyu Liu2†, Taifu You2, Xiongxiong Liu2, Runzhang Liu2, Zeyang Li2, Chunyu Zhen2, Yunxia Zhang2, Xingguang Liu2,4,5* and Hui Cai3,4,5*  \nAbstract  \nObjective It has been demonstrated that IDO1, a target of immune checkpoint inhibition, functions as an oncogene in the majority of human malignancies. IDO1’s function in human pan-cancers hasn’t been thoroughly studied, though.  \nMaterials and methods The Kaplan–Meier (K-M) and COX analyses were applied to the survival analysis. Furthermore, we used Spearman’s correlation analysis to examine the associations between IDO1 and microsatellite instability (MSI), DNA methyltransferases (DNMTs), tumor mutational burden (TMB), the associated genes of mismatch repair (MMR), and immune checkpoint biomarkers. Moreover, immunohistochemical analysis and qRT-PCR were used to evaluate IDO1’s expression in pan-cancer cells.  \nResults The findings ofthis study reveal that IDO1 has abnormal expression in a number of malignancies  \nand is related to the prognosis for UVM, LGG, KIRP, GBM, LAML, OV, READ, MESO, SARC, SKCM, and HNSC. Furthermore, the aberrant IDO1 expression was connected to the TMB, MSI, MMR, drug sensitivity, immune cells infiltrating, and tumor immune microenvironment across a variety of cancer types. The PCR results showed that in contrast to normal cells, IDO1 was found to be significantly highly expressed in breast cancer cells and hepatocellular carcinoma cells, and significantly lowly expressed in gastric cancer cells.  \nConclusion The clinical treatment of IDO1 is now better supported by a theoretical basis and guidelines provided by our study.  \nKeywords IDO1, Prognosis, Bioinformatics analysis, Cancers  \n†Kaili Lin, Yongfeng Wang and Fangyu Liu have the co-first authors.  \n*Correspondence:  \nXingguang Liu [chenhongkouqiang@126.com](chenhongkouqiang@126.com)[ ](chenhongkouqiang@126.com)Hui Cai  \n[caialonteam@163.com](caialonteam@163.com)  \n1 Lanzhou First People’s Hospital, Lanzhou 730000, Gansu, China  \n2 Present Address: The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu, China  \n3 General Surgery Clinical Medical Center, Gansu Provincial Hospital, Lanzhou, 204 Donggang West Road, Lanzhou 730000, Gansu, China  \n4 Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province, Gansu Provincial Hospital, Lanzhou 730000, Gansu, China  \n5 NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou 730000, Gansu, China  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ()[. The Creative Commons Public Domain Dedication waiver (]","cbCaijQvfu25N28o","https://ap.wps.com/l/cbCaijQvfu25N28o","pdf",15356839,"English","# Abstract\n# Objective\n# Materials and methods\n# Results\n# Conclusion\n# Keywords\n# Introduction","[{\"question\":\"What is the main objective of this study?\",\"answer\":\"To assess the prognostic value and immunological role of the IDO1 gene across pan-cancer, given limited prior characterization.\"},{\"question\":\"What methods were used to analyze IDO1 and patient outcomes?\",\"answer\":\"Kaplan–Meier and COX analyses were applied for survival analysis, supported by Spearman correlation analyses with genomic and immune biomarkers.\"},{\"question\":\"What major associations did the study find for IDO1?\",\"answer\":\"IDO1 showed abnormal expression and related prognosis in multiple cancers, and its aberrant expression correlated with TMB, MSI, MMR, drug sensitivity, immune cell infiltration, and the tumor immune microenvironment.\"}]","Comprehensive analysis of the prognostic value and immunological role of IDO1 gene in pan-cancer | PDF",1789988331,48]