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Its interaction with the kisspeptin receptor can also reshape tumor-relevant signaling, affecting proliferation and metastasis. The study screened ten kisspeptin-10 (KP10) analogs across multiple cancer types with emphasis on cervical cancer, then used kinase array assays, migration assays, and Bioluminescence Resonance Energy Transfer to define receptor binding and kinase modulation. Results indicate KP10 analogs inhibit cervical cancer cell growth and reduce motility, supporting therapeutic potential in disease progression.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comprehensive-analysis-of-kisspeptin-signaling-effects-on-cellular-dynamics-in-cervical-cancer/331209/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comprehensive-analysis-of-kisspeptin-signaling-effects-on-cellular-dynamics-in-cervical-cancer/331209.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What biological function does kisspeptin have in reproduction?","Question",{"text":112,"@type":113},"Kisspeptin regulates the hypothalamic–pituitary–gonadal axis by stimulating GnRH release, which then drives pituitary secretion of gonadotropic hormones and controls fertility and puberty.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the kisspeptin receptor affect cancer-related cellular behavior?",{"text":117,"@type":113},"The kisspeptin–receptor interaction can modulate tumor-associated processes such as proliferation and metastasis through downstream kinase signaling and related cellular pathways.",{"name":119,"@type":110,"acceptedAnswer":120},"What evidence supports the therapeutic potential of KP10 analogs in cervical cancer?",{"text":121,"@type":113},"The study reports that KP10 analogs reduce cervical cancer cell proliferation, decrease cell motility in migration assays, and show strong interaction with the kisspeptin receptor, alongside kinase changes revealed by kinase array assays.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331209,1790241570,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","biomolecules  \nArticle  \nComprehensive Analysis of Kisspeptin Signaling: Effects on Cellular Dynamics in Cervical Cancer  \nDeisy Yurley Rodríguez-Sarmiento 1, *, Paola Rondón-Villarreal 2, Pedro Henrique Scarpelli-Pereira 3 and Michel Bouvier 3  \nCitation: Rodríguez-Sarmiento, D.Y.; Rondón-Villarreal, P.;  \nScarpelli-Pereira, P.H.; Bouvier, M. Comprehensive Analysis of Kisspeptin Signaling: Effects on Cellular Dynamics in Cervical Cancer. Biomolecules 2024, 14, 923. [https://](https://)[ ](https://)[doi.org/10.3390/biom14080923](doi.org/10.3390/biom14080923)  \nAcademic Editor: David Puett  \nReceived: 18 May 2024  \nRevised: 4 July 2024  \nAccepted: 9 July 2024  \nPublished: 29 July 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Faculty of Health Sciences, Universidad Autónoma de Bucaramanga, Bucaramanga 680003, Colombia  \n2 Instituto de Investigación Masira, Facultad de Ciencias Médicas y de la Salud, Universidad de Santander, Bucaramanga 680003, Colombia; [diseno.molecular@udes.edu.co](diseno.molecular@udes.edu.co)  \n3 Department of Biochemistry, Institute for Research in Immunology and Cancer (IRIC), Université de Montreal, Montreal, QC H3T 1J4, Canada; pedro.henrique.scarpelli.pereira@umontreal.ca (P.H.S.-P.); [michel.bouvier@umontreal.ca](michel.bouvier@umontreal.ca) (M.B.)  \n* Correspondence: [drodriguez184@unab.edu.co](drodriguez184@unab.edu.co); Tel.: +57-3186319959  \nAbstract: Kisspeptin, a key neuropeptide derived from the KISS1R gene, is renowned for its critical role in regulating the hypothalamic–pituitary–gonadal axis and reproductive hormone secretion. Beyond its primary function in reproductive biology, emerging research has illuminated its influence in various cancers, mediating significant effects through its interaction with the G protein-coupled receptor, kisspeptin receptor. This interaction has been implicated in modulating cellular processes such as proliferation and metastasis, making it a potential target for therapeutic intervention. Our study initially screened ten kisspeptin-10 analogs through cytotoxic effects of kisspeptin-10 (KP10) and its analogs in several cancer types, including cervical, prostate, breast, and gastric cancers, with a particular focus on cervical cancer, where the most profound effects were observed. Further exploration using kinase array assays revealed that these analogs specifically alter key kinases involved in cancer progression. Migration assays demonstrated a substantial decrease in cell motility, and Bioluminescence Resonance Energy Transfer assays confirmed these analogs’ strong interactions with the kisspeptin receptor. Overall, our results indicate that these KP10 analogs not only hinder cervical cancer cell proliferation but also curtail migration through targeted modulation of kinase signaling, suggesting their potential as therapeutic agents in managing cervical cancer progression. This comprehensive approach underscores the therapeutic promise of exploiting kisspeptin signaling in cancer treatment strategies.  \nKeywords: kisspeptin receptor; kisspeptin; cancer; cytotoxicity; signal transduction  \n1. Introduction  \nG protein-coupled receptors (GPCRs) are critical for cellular signal transduction and are major targets in pharmaceutical research [1,2] . Structurally, GPCRs have N-and Cterminal regions and seven transmembrane segments [3] . Upon ligand binding, GPCRs activate G proteins, leading to downstream signaling like cAMP activation, ERK1/2 phosphorylation, and calcium mobilization [4] .  \nKisspeptin receptor is a G protein-coupled receptor (GPCR) that activates the G proteins Gα q/11 and its natural ligand is kisspeptin [5], a family of structural","cbCairrBu45XU82e","https://ap.wps.com/l/cbCairrBu45XU82e","pdf",3456691,16,"English","# Introduction\n## GPCR signaling overview\n## Kisspeptin receptor and KISS1R-derived peptides\n## Roles of kisspeptin in endocrine regulation\n## Non-canonical roles in cancer progression","[{\"question\":\"What biological function does kisspeptin have in reproduction?\",\"answer\":\"Kisspeptin regulates the hypothalamic–pituitary–gonadal axis by stimulating GnRH release, which then drives pituitary secretion of gonadotropic hormones and controls fertility and puberty.\"},{\"question\":\"How does the kisspeptin receptor affect cancer-related cellular behavior?\",\"answer\":\"The kisspeptin–receptor interaction can modulate tumor-associated processes such as proliferation and metastasis through downstream kinase signaling and related cellular pathways.\"},{\"question\":\"What evidence supports the therapeutic potential of KP10 analogs in cervical cancer?\",\"answer\":\"The study reports that KP10 analogs reduce cervical cancer cell proliferation, decrease cell motility in migration assays, and show strong interaction with the kisspeptin receptor, alongside kinase changes revealed by kinase array assays.\"}]","Comprehensive Analysis of Kisspeptin Signaling - Effects on Cellular Dynamics in Cervical Cancer | PDF",1789992224]