[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-435820-105":59,"doc-detail-435820-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","complete-remission-of-metastatic-osteosarcoma-from-a-breast-malignant-phyllodes-tumor-a-case-report","Complete Remission of Metastatic Osteosarcoma From a Breast Malignant Phyllodes Tumor - A Case Report","","Phyllodes tumors are rare biphasic fibroepithelial lesions, and about one fifth of malignant cases metastasize via the bloodstream, most often to lungs and bones. The report describes a 39-year-old woman previously diagnosed with breast malignant phyllodes tumor who developed metastatic involvement of the upper humeral bone. High-dose systemic chemotherapy with radiotherapy was used to induce remission, followed by surgical resection of the remnant tumor and adjuvant chemotherapy with doxorubicin and cisplatin.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/complete-remission-of-metastatic-osteosarcoma-from-a-breast-malignant-phyllodes-tumor-a-case-report/435820/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/complete-remission-of-metastatic-osteosarcoma-from-a-breast-malignant-phyllodes-tumor-a-case-report/435820.png","ImageObject",300,407,{"name":92,"@type":93},"moss~","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the clinical significance of malignant phyllodes tumors in this report?","Question",{"text":112,"@type":113},"Malignant phyllodes tumors can metastasize hematogenously, and treatment is difficult because distant metastasis is uncommon and outcomes are often poor.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the metastasis to the humeral bone present in the case?",{"text":117,"@type":113},"The patient was rehospitalized for a left humeral fracture, and pathology from humeral tissue showed metastatic phyllodes tumor with osteosarcomatous differentiation.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment approach led to complete remission?",{"text":121,"@type":113},"The patient received systemic high-dose chemotherapy combined with radiotherapy to achieve complete remission, followed by surgical removal of the residual tumor and adjuvant chemotherapy with doxorubicin and cisplatin.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},435820,1791166319,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962090895452,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","J Breast Cancer. 2025 Dec;28(6):448-453 [https://doi.org/10.4048/jbc.2025.0153](https://doi.org/10.4048/jbc.2025.0153)[ ](https://doi.org/10.4048/jbc.2025.0153)pISSN 1738-6756·eISSN 2092-9900  \nCase Report  \nReceived: Jun 25, 2025  \nRevised: Aug 26, 2025  \nAccepted: Sep 30, 2025  \nPublished online: Oct 14, 2025  \nCorrespondence to  \nHaa-Na Song  \nDivision of Hemato-oncology, Department of Internal Medicine, Gyeongsang National University of Hospital, Gyeongsang National University College of Medicine, 79 Gangnamro, Jinju 52727, Korea.  \nEmail: [shn61@gnu.ac.kr](shn61@gnu.ac.kr)  \n© The Authors 2025  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([https://](https://)[ ](https://)[creativecommons.org/licenses/by-nc/4.0/](creativecommons.org/licenses/by-nc/4.0/)) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nORCID iDs  \nHaa-Na Song  [https://orcid.org/0000-0002-7229-0153](https://orcid.org/0000-0002-7229-0153)[ ](https://orcid.org/0000-0002-7229-0153)Min Hye Kim  [https://orcid.org/0000-0002-8631-5104](https://orcid.org/0000-0002-8631-5104)  \nConflict of Interest  \nThe authors declare that they have no competing interests.  \nData Availability  \nIn accordance with the ICMJE data-sharing policy, the authors agree to make data available upon request.  \nComplete Remission of Metastatic Osteosarcoma From a Breast Malignant Phyllodes Tumor: A Case Report  \nHaa-Na Song  1, Min Hye Kim  2  \n1Division of Hemato-oncology, Department of Internal Medicine, Gyeongsang National University of Hospital, Gyeongsang National University College of Medicine, Jinju, Korea  \n2Department of Pathology, Gyeongsang National University of Hospital, Gyeongsang National University College of Medicine, Jinju, Korea  \nABSTRACT  \nPhyllodes tumors (PTs) are biphasic fibroepithelial lesions. Approximately 20% of malignant PTs metastasize hematogenously, most commonly to the lungs and bones. Treatment of metastatic PT is challenging because of its rarity. A 39-year-old woman with a left humeral fracture was admitted to our hospital. She had been diagnosed with breast PT a year prior, and humeral bone tissue pathology showed a metastatic PT similar to her breast PT. The patient received systemic high-dose chemotherapy, including etoposide, ifosfamide, and cisplatin, concurrently combined with radiotherapy to facilitate remission, after which the remnant tumor was removed. After achieving complete remission, the patient received chemotherapy with doxorubicin and cisplatin as adjuvants. To the best of our knowledge, this is the first report of a metastatic PT in which complete remission was achieved with highdose chemotherapy combined with radiotherapy, followed by surgical resection and adjuvant chemotherapy.  \nKeywords: Drug Therapy; Osteosarcoma; Phyllodes Tumor  \nINTRODUCTION  \nPhyllodes tumors (PTs) are rare biphasic fibroepithelial tumors that account for less than 1% of all breast neoplasms [1]. They occur predominantly in middle-aged women and are generally characterized by a rapidly growing, large, palpable, painless breast mass [2] . Most PTs are benign, with malignancy occurring in up to 25% of cases. Moreover, approximately 10%–20% of malignant PTs are associated with distant metastasis, which occurs  \nvia the hematogenous route, with the lung being the most common metastatic site, followed by soft tissue and bone. Treatment of malignant PT associated with distant metastasis is limited, and its prognosis remains poor [3] .  \nPTs usually comprise epithelial and stromal tissues. The stromal component carries a high risk of malignant transformation and sarcomatous features, such as chondrosarcoma,  \n[https://ejbc.kr](https://ejbc.kr) 448  \nRemission of Metastatic Osteosarcoma From Malignant Phyllodes Tumor  \nAuthor Contributions  \nConceptualization: Song HN; Data curation: Kim MH; Formal analy","cbCais5cj3oWfdMY","https://ap.wps.com/l/cbCais5cj3oWfdMY","pdf",5299559,"English","# Abstract\n# Introduction\n# Case Report\n## Presentation and initial diagnosis\n## Recurrence with humeral fracture and metastasis workup\n## Treatment and outcome","[{\"question\":\"What is the clinical significance of malignant phyllodes tumors in this report?\",\"answer\":\"Malignant phyllodes tumors can metastasize hematogenously, and treatment is difficult because distant metastasis is uncommon and outcomes are often poor.\"},{\"question\":\"How did the metastasis to the humeral bone present in the case?\",\"answer\":\"The patient was rehospitalized for a left humeral fracture, and pathology from humeral tissue showed metastatic phyllodes tumor with osteosarcomatous differentiation.\"},{\"question\":\"What treatment approach led to complete remission?\",\"answer\":\"The patient received systemic high-dose chemotherapy combined with radiotherapy to achieve complete remission, followed by surgical removal of the residual tumor and adjuvant chemotherapy with doxorubicin and cisplatin.\"}]","Complete Remission of Metastatic Osteosarcoma From a Breast Malignant Phyllodes Tumor - A Case Report | PDF",1790675423,15]