[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-333232-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-333232-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","competitive-endogenous-rna-networks-decoding-the-role-of-long-non-coding-rnas-and-circular-rnas-in-colorectal-cancer-chemoresistance-review","Competitive endogenous RNA networks - Decoding the role of long non-coding RNAs and circular RNAs in colorectal cancer chemoresistance - Review","","Colorectal cancer (CRC) is among the most prevalent gastrointestinal malignancies worldwide, yet effective therapy remains constrained by chemotherapy-induced drug resistance. Non-coding RNAs are implicated in CRC development and in cellular responses to treatment, but mechanisms linking diverse ncRNAs are still not fully understood. Competitive endogenous RNA (ceRNA) networks integrate lncRNA/miRNA/mRNA and circRNA/miRNA/mRNA interactions; dysregulation of these networks correlates with proliferation, apoptosis, and angiogenesis and may promote chemoresistance. This review addresses lncRNA- and circRNA-associated ceRNA networks underlying drug resistance in colorectal carcinogenesis, supporting advances in diagnostic and therapeutic strategies.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/competitive-endogenous-rna-networks-decoding-the-role-of-long-non-coding-rnas-and-circular-rnas-in-colorectal-cancer-chemoresistance-review/333232/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/competitive-endogenous-rna-networks-decoding-the-role-of-long-non-coding-rnas-and-circular-rnas-in-colorectal-cancer-chemoresistance-review/333232.png","ImageObject",300,407,{"name":42,"@type":43},"Finn","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is chemotherapy resistance a major challenge in colorectal cancer?","Question",{"text":63,"@type":64},"Many CRC patients develop resistance after prolonged chemotherapy use, reducing therapeutic effectiveness and leading to treatment failure. Resistance is associated with changes such as altered repair of DNA damage, target alterations, and other cellular adaptations.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What role do non-coding RNAs play in CRC and response to chemotherapy?",{"text":68,"@type":64},"Non-coding RNAs (ncRNAs) contribute to CRC development and influence how cells respond to chemotherapy. Their dysregulation affects processes including proliferation, apoptosis, and angiogenesis.",{"name":70,"@type":61,"acceptedAnswer":71},"How do competitive endogenous RNA (ceRNA) networks relate to chemoresistance?",{"text":72,"@type":64},"ceRNA networks connect lncRNA/miRNA/mRNA and circRNA/miRNA/mRNA interactions. Dysregulation of these networks is linked to CRC progression and, in some contexts, may contribute to the emergence of chemoresistance.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},333232,1790005210,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","DOI: 10. 1111/jcmm.18197  \nRE V I E W  \nCompetitive endogenous RNA networks: Decoding the role of long non-coding RNAs and circular RNAs in colorectal cancer chemoresistance  \nAli Khalafizadeh1  | Seyedeh Donya Hashemizadegan1 | Fatemeh Shokri2 | Babak Bakhshinejad1 | Keyvan Jabbari1 | Mahsa Motavaf1 | Sadegh Babashah1,2  \n1Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran 2Research and Development Center of Biotechnology, Tarbiat Modares University, Tehran, Iran  \nCorrespondence  \nSadegh Babashah, Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, P.O. Box: 14115-154, Tehran, Iran.  \nEmail: [sadegh.babashah@gmail.com](sadegh.babashah@gmail.com); [babashah@modares.ac.ir](babashah@modares.ac.ir)  \nAbstract  \nColorectal cancer (CRC) is recognized as one of the most common gastrointestinal malignancies across the globe. Despite significant progress in designing novel treatments for CRC, there is a pressing need for more effective therapeutic approaches. Unfortunately, many patients undergoing chemotherapy develop drug resistance, posing a significant challenge for cancer treatment. Non-coding RNAs (ncRNAs) have been found to play crucial roles in CRC development and its response to chemotherapy. However, there are still gaps in our understanding of interactions among various ncRNAs, such as long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs) . These ncRNAs can act as either oncogenesor tumour suppressors, affecting numerous biological functions in different cancers including CRC. A class of ncRNA molecules known as competitive endogenous RNAs (ceRNAs) has emerged as a key player in various cellular processes. These molecules form networks through lncRNA/miRNA/mRNA and circRNA/miRNA/mRNA interactions. In CRC, dysregulation of ceRNA networks has been observed across various cellular processes, including proliferation, apoptosis and angiogenesis. These dysregulations are believed to play a significant role in the progression of CRC and, in certain instances, may contribute to the development of chemoresistance. Enriching our knowledge of these dysregulations holds promise for advancing the field of diagnostic and therapeutic modalities for CRC. In this review, we discuss lncRNA-and circRNA-associated ceRNA networks implicated in the emergence and advancement of drug resistance in colorectal carcinogenesis.  \nK E Y WO R D S  \nchemosensitivity, circular RNA, colorectal cancer, competitive endogenous RNA, long noncoding RNA, microRNA  \n\n| Ali Khalafizadeh and Seyedeh Donya Hashemizadegan contributed equally to this work. |\n| --- |\n| This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.\u003Cbr>© 2024 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. |\n\nJ Cell Mol Med. 2024;28:e18197 .  \n[https://doi.org/10.1111/jcmm.18197](https://doi.org/10.1111/jcmm.18197)  \n[wileyonlinelibrary.com/journal/jcmm](wileyonlinelibrary.com/journal/jcmm)  \n1 of 23  \n1 | INTRODUCTION  \nAccording to annual incidence rates, colorectal cancer (CRC) is recognized as one of the most common forms of gastrointestinal malignancies across the globe.1 A report by Siegel et al.2 estimates that in 2023, there will be 1,958,310 new cancer cases and 609,820 cancerrelated deaths in the United States. Of these, 153,020 are attributed to new cases of CRC, and there are expected to be 52,550 deaths related to CRC. While aging and lifestyle choices account for a significant proportion of CRC cases, underlying genetic diseases contribute to a smaller portion of overall CRC occurrence. The increased prevalence of CRC has been correlated with an unhealthy lifestyle, including the consumption of tobacco, alcohol and red me","cbCaiaAIK5z1SJxW","https://ap.wps.com/l/cbCaiaAIK5z1SJxW","pdf",3495755,23,"English","# Abstract\n# Introduction\n## Colorectal cancer burden and unmet therapeutic needs\n## Chemotherapy, drug resistance, and mechanisms\n## Key resistance molecules and signaling influences\n## Non-coding RNAs and ceRNA framework","[{\"question\":\"Why is chemotherapy resistance a major challenge in colorectal cancer?\",\"answer\":\"Many CRC patients develop resistance after prolonged chemotherapy use, reducing therapeutic effectiveness and leading to treatment failure. Resistance is associated with changes such as altered repair of DNA damage, target alterations, and other cellular adaptations.\"},{\"question\":\"What role do non-coding RNAs play in CRC and response to chemotherapy?\",\"answer\":\"Non-coding RNAs (ncRNAs) contribute to CRC development and influence how cells respond to chemotherapy. Their dysregulation affects processes including proliferation, apoptosis, and angiogenesis.\"},{\"question\":\"How do competitive endogenous RNA (ceRNA) networks relate to chemoresistance?\",\"answer\":\"ceRNA networks connect lncRNA/miRNA/mRNA and circRNA/miRNA/mRNA interactions. Dysregulation of these networks is linked to CRC progression and, in some contexts, may contribute to the emergence of chemoresistance.\"}]","Competitive endogenous RNA networks - Decoding the role of long non-coding RNAs and circular RNAs in colorectal cancer chemoresistance - Review | PDF",1790001587,58]