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Methods A retrospective review includes 127 patients treated with brain radiotherapy from 2014 to 2023; outcomes assessed include overall survival (OS), intracranial progression-free survival (iPFS), objective response rate (ORR), and local control rate (LCR). Results WBRT + SIB improves median OS (18.0 vs. 11.7 months) and iPFS (12.2 vs. 7.6 months), with subgroup and interaction findings supporting benefit. 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Overall survival (OS), intracranial progression-free survival (iPFS), objective response rate (ORR), and local control rate (LCR) were evaluated.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the main efficacy results of WBRT + SIB versus WBRT?",{"text":122,"@type":114},"WBRT + SIB significantly improved median OS (18.0 vs. 11.7 months) and extended iPFS (12.2 vs. 7.6 months), with Kaplan-Meier analysis showing a significant OS benefit.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},370755,1790218880,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336477405376,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Shan etal. BMC Cancer (2025) 25:1210 BMC Cancer  \n[https://doi.org/10.1186/s12885-025-14593-z](https://doi.org/10.1186/s12885-025-14593-z)  \nRESEARCH Open Access  \nComparison the efficiency of whole brain radiotherapy and simultaneous integrated boost in small cell lung cancer with brain metastases  \nXia Shan 1†, Wenqing Wang 1†, Tao Zhang 1, Wenyang Liu 1, Jianyang Wang 1, Xin Wang 1, Yuqi Wu 1, Zefen Xiao 1, Jima Lv 1, Qinfu Feng 1, Nan Bi 1*, Zongmei Zhou 1* and Lei Deng 1*  \nAbstract  \nBackground This study aims to compare the therapeutic efficacy of whole brain radiotherapy (WBRT) versus WBRT plus simultaneous integrated boost (WBRT + SIB) in patients with brain metastases (BMs) from small cell lung cancer (SCLC) .  \nMethods A retrospective analysis was conducted on 127 patients with BMs from SCLC who received brain radiotherapy between 2014 and 2023 at the Cancer Hospital of the Chinese Academy of Medical Science. Among them, 71 patients underwent WBRT (25 .0–54. 0 Gy in 10–21 fractions), while 56 patients received WBRT + SIB (SIB to metastases: 18.0–60. 0 Gy in 5–20 fractions) . The overall survival (OS), intracranial progression-free survival (iPFS), objective response rate (ORR), and local control rate (LCR) were evaluated to assess the efficacy of the treatments. Results With a median follow-up of 14.9 months, the median OS was significantly longer in the WBRT + SIB group compared to the WBRT group (18 .0 vs. 11.7 months) . Similarly, the iPFS was extended in the WBRT + SIB group (12 .2 vs. 7.6 months) . Kaplan-Meier analysis revealed that WBRT + SIB significantly improved OS in patients with SCLC of BMs (P = 0 . 009) . Subgroup analysis indicated that male patients, age \u003C 60 years old, and multiple intracranial metastases benefited more from WBRT + SIB. Interaction tests suggested that age significantly influence the efficacy of  \nWBRT + SIB, with patients \u003C 60 years old deriving more benefit (P = 0 . 049) . Concurrent WBRT + SIB with anti-angiogenic targeted therapy significantly improved iPFS (P \u003C 0. 001) .  \nConclusions WBRT + SIB can prolong the OS in SCLC patients with BMs, with younger age and those receiving antiangiogenesis therapy potentially achieving additional survival benefits.  \n†Xia Shan and Wenqing Wang contributed equally to this work.  \n*Correspondence:  \nNan Bi  \n[binan_email@163.com](binan_email@163.com)[ ](binan_email@163.com)Zongmei Zhou [zhouzongmei2013@163.com](zhouzongmei2013@163.com)[ ](zhouzongmei2013@163.com)Lei Deng [dengleipumc@163.com](dengleipumc@163.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/l](vecommons.org/l)icenses/by-nc-nd/4.0/.  \nShan et al. BMC Cancer (2025) 25:1210 Page 2 of 9  \nKeywords Small cell lung cancer (SCLC), Brain metastases, Whole brain radiotherapy (WBRT), Simultaneous integrated boost (SIB), Therapeutic efficacy  \nBackground  \nSmall cell lung cancer (SCLC) is a poorly differentiated, high-grade neuroendocrine","cbCaii7IWfimTXFW","https://ap.wps.com/l/cbCaii7IWfimTXFW","pdf",1755170,"English","# Background\n# Methods\n# Results\n# Conclusions\n# Keywords\n# Introduction","[{\"question\":\"What treatments are compared in this study?\",\"answer\":\"The study compares whole brain radiotherapy (WBRT) alone with WBRT plus simultaneous integrated boost (WBRT + SIB) for small cell lung cancer patients with brain metastases.\"},{\"question\":\"How many patients were included and what outcomes were evaluated?\",\"answer\":\"A retrospective analysis included 127 patients. Overall survival (OS), intracranial progression-free survival (iPFS), objective response rate (ORR), and local control rate (LCR) were evaluated.\"},{\"question\":\"What were the main efficacy results of WBRT + SIB versus WBRT?\",\"answer\":\"WBRT + SIB significantly improved median OS (18.0 vs. 11.7 months) and extended iPFS (12.2 vs. 7.6 months), with Kaplan-Meier analysis showing a significant OS benefit.\"}]","Comparison the efficiency of whole brain radiotherapy and simultaneous integrated boost in small cell lung cancer with brain metastases | PDF",1790190223,23]