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A retrospective analysis covered 87 patients developing mediastinitis after sternotomy between January 2010 and January 2023, divided into conventional (n=39) and NPWT (n=48) groups. NPWT shortened treatment duration, time to negative cultures, and hospital stay, and reduced hospital mortality compared with conventional care. Results support NPWT as a more effective option for this serious postoperative complication.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comparison-of-treatment-approaches-for-mediastinitis-after-coronary-artery-bypass-grafting-negative-pressure-wound-therapy-versus-conventional-methods/445500/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comparison-of-treatment-approaches-for-mediastinitis-after-coronary-artery-bypass-grafting-negative-pressure-wound-therapy-versus-conventional-methods/445500.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of this study?","Question",{"text":112,"@type":113},"To compare the effectiveness of negative-pressure wound therapy (NPWT) versus conventional methods for treating mediastinitis after coronary artery bypass grafting.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients grouped in the analysis?",{"text":117,"@type":113},"Patients were retrospectively divided into a conventional treatment group (n=39) treated from January 2010 to February 2015 and an NPWT group (n=48) treated from March 2015 to January 2023.",{"name":119,"@type":110,"acceptedAnswer":120},"What outcomes were measured and how did NPWT perform?",{"text":121,"@type":113},"Treatment duration, time to negative cultures, hospital stay, and mortality rate were recorded; NPWT achieved shorter durations, faster negative cultures, shorter hospitalization, and lower hospital mortality than conventional methods.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},445500,1790792974,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","Turkish Journal of Thoracic and Cardiovascular Surgery 2025;33(4):412-422  \nOrıgınal Artıcle / Özgün Makale  \nComparison of treatment approaches for mediastinitis after coronary artery bypass grafting: Negative pressure wound therapy versus conventional methods  \nKoroner arter baypas greftleme sonrası mediastinit tedavisinde tedavi yaklaşımlarının karşılaştırıl ması: Negatif basınçlı yara tedavisi ile konvansiyonel yöntemler  \nHasan Toz􀀬, Yusuf Kuserli􀀬, Gülsüm Türkyılmaz􀀬, Ali Aycan Kavala􀀬, Saygın Türkyılmaz􀀬  \nDepartment of Cardiovascular Surgery, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Türkiye  \nABSTRACT  \nBackground: This study aims to compare the effectiveness of negative-pressure wound therapy (NPWT) compared to conventional methods for the treatment of mediastinitis following coronary artery bypass grafting.  \nMethods: Between January 2010 and January 2023, a total of 87 patients (47 males, 40 females; mean age: 62.0±10.2 years; range, 35 to 80 years) who developed mediastinitis following sternotomy were retrospectively analyzed. The patients were divided into two groups: those treated with conventional methods (n=39) from January 2010 to February 2015 and those treated with NPWT (n=48) from March 2015 to January 2023. Clinical outcomes, including treatment duration, infection resolution time, hospital stay, and mortality rate, were recorded.  \nResults: The NPWT group had significantly shorter treatment durations (20.1±4.0 days) than the conventional group (58.6±17.1 days, p\u003C0.001) . The time to achieve negative cultures was also significantly reduced in the NPWT group (15.3±3.6 days) compared to the conventional group (36.7±8.1 days, p\u003C0.001) . The length of hospital stay was shorter in the NPWT group (34.3±12.8 days) compared to the conventional group (88.0±21.1 days, p\u003C0.001) . The NPWT group had a lower hospital mortality rate (4.2%) than the conventional group (17.9%, p=0.049) .  \nConclusion: The NPWT demonstrated superior efficacy in managing postoperative mediastinitis compared to conventional methods, highlighting its potential as a preferred treatment option for this serious complication.  \nKeywords: Coronary artery bypass grafting, mediastinitis, negativepressure wound therapy, postoperative complications, wound healing.  \nMediastinitis is a potentially severe and lifethreatening infection which may arise following cardiac interventions, particularly isolated coronary artery bypass grafting (CABG) . [1] This condition  \nÖZ  \nAmaç: Bu çalışmada, koroner arter baypas greftlemesonrası gelişen mediastinit tedavisinde negatif basınçlı yaratedavisinin (NPWT) etkinliği konvansiyonel yöntemler ile karşılaştırıldı .  \nÇalışma planı: Ocak 2010 - Ocak 2023 tarihleri arasındasternotomi sonrası mediastinit gelişen toplam 87 hasta (47 erkek, 40 kadın; ort. yaş: 62.0±10.2 yıl; dağılım, 35-80 yıl) retrospektif olarak incelendi. Hastalar, Ocak 2010 - Şubat 2015 tarihleri arasında konvansiyonel yöntemlerle tedavi edilenler (n=39) ve Mart 2015 - Ocak 2023 arasında NPWT uygulananlar (n=48) olmak üzere iki gruba ayrıldı . Tedavi süresi, enfeksiyon iyileşmesüresi, hastanede yatış süresi ve mortalite oranları dahil olmak üzere klinik sonuçlar kaydedildi.  \nBulgular: Negatif basınçlı yara tedavi grubunda tedavi süresikonvansiyonel gruba kıyasla (58.6±17.1 gün) anlamlı olarak daha kısa idi (20.1±4.0 gün, p\u003C0.001) . Negatif kültür elde etmesüresi de, konvansiyonel gruba kıyasla (36.7±8.1 gün), NPWT grubunda anlamlı düzeyde kısaldı (15.3±3.6 gün; p\u003C0.001) . Hastanede kalış süresi, konvansiyonel gruba kıyasla (88.0±21.1 gün), NPWT grubunda daha kısa idi (34.3±12.8 gün; p\u003C0.001) . Hastane mortalitesi, konvansiyonel gruba kıyasla (%17.9), NPWT grubunda daha düşük idi (%4.2; p=0.049) .  \nSonuç: Negatif basınçlı yara tedavisi ameliyat sonrası mediastinit yönetiminde konvansiyonel yöntemlere kıyasla üstün etkinlikgöstermiş olup, bu ciddi komplikasyonun tedavisinde tercihedilebilecek bir yöntem olarak öne çıkmaktadır","cbCailZnCfZykuP8","https://ap.wps.com/l/cbCailZnCfZykuP8","pdf",390164,11,"English","# Abstract\n## Methods and Groups\n## Results and Outcomes\n## Conclusion and Keywords","[{\"question\":\"What is the main purpose of this study?\",\"answer\":\"To compare the effectiveness of negative-pressure wound therapy (NPWT) versus conventional methods for treating mediastinitis after coronary artery bypass grafting.\"},{\"question\":\"How were patients grouped in the analysis?\",\"answer\":\"Patients were retrospectively divided into a conventional treatment group (n=39) treated from January 2010 to February 2015 and an NPWT group (n=48) treated from March 2015 to January 2023.\"},{\"question\":\"What outcomes were measured and how did NPWT perform?\",\"answer\":\"Treatment duration, time to negative cultures, hospital stay, and mortality rate were recorded; NPWT achieved shorter durations, faster negative cultures, shorter hospitalization, and lower hospital mortality than conventional methods.\"}]","Comparison of treatment approaches for mediastinitis after coronary artery bypass grafting - Negative pressure wound therapy versus conventional methods | PDF",1790712285,28]