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Efficacy and safety of IMT were compared with conventional chemo(radio)therapy (CT) in advanced/metastatic gastrointestinal cancers across colorectal, pancreatic, cholangiocellular, gastric, and esophageal subgroups. After IMT initiation, median survival increased in several groups, with locoregional modulated electro-hyperthermia showing the strongest overall survival benefit and CT proving most effective when introduced early.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comparison-of-the-effectiveness-of-integrative-immunomodulatory-treatments-and-conventional-therapies-on-the-survival-of-selected-gastrointestinal-cancer-patients/384235/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comparison-of-the-effectiveness-of-integrative-immunomodulatory-treatments-and-conventional-therapies-on-the-survival-of-selected-gastrointestinal-cancer-patients/384235.png","ImageObject",300,407,{"name":92,"@type":93},"Franzy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was compared in the study for gastrointestinal cancer patients?","Question",{"text":112,"@type":113},"The study compared integrative immunomodulatory treatments (IMT) with conventional chemo(radio)therapy (CT) in advanced/metastatic gastrointestinal cancer patients.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which IMT approach showed the most positive effect on overall survival?",{"text":117,"@type":113},"Locoregional modulated electro-hyperthermia showed the most positive effect on overall survival among the IMTs evaluated.",{"name":119,"@type":110,"acceptedAnswer":120},"How did CT versus IMT perform in patient survival overall and by subgroup?",{"text":121,"@type":113},"Overall, IMTs showed minimal effect on survival, while CT had the greatest effect when introduced as early as possible. IMT was superior to CT in pancreatic cancer, while only modest effects were detected in colorectal cancer.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},384235,1790727876,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},2336478945519,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nComparison of the effectiveness of integrative immunomodulatory treatments and conventional therapies on the survival of selected gastrointestinal cancer patients  \nRalf Kleef1, Magdolna Dank2, Magdolna Herold2,3, Emese Irma Agoston4, Julia Lohinszky3, Emoke Martinek2, Zoltan Herold2 & Attila Marcell Szasz2*  \nIn the last decade, the use of immunomodulating treatments (IMT) at integrative oncology providers (IOP) increased. IMTs are used to modulate the tumor microenvironment, which might lead to increased response-to-treatment, and the indication of immune checkpoint inhibitors might also be widened. The efficacy and safety of IMTs in advanced/metastatic gastrointestinal cancers were compared with conventional chemo(radio)therapy (CT). 21 colorectal–(CRC), 14 pancreatic–(PC), 5 cholangiocellular–(CCC), 5 gastric–(GC) and 4 esophageal cancer (EC) patients received IMT. IMT and CT were compared inCRC and PC. CT was administered at an academic oncology center. After the initiation of IMT, a median survival of ~ 20 (CRC, PC and EC) and ~ 10 months (CCC and GC) was observed. Ofthe IMTs, locoregional modulated electro-hyperthermia had the most positive effect on overall survival (HR: 0.3055; P = 0.0260), while fever-inducing interleukin-2, and low-dose ipilimumab showed a positive tendency. IMT was superior toCT in PC (HR: 0.1974; P = 0.0013), while modest effect was detected inCRC (HR: 0.7797; P = 0.4710). When the whole study population was analyzed, IMTs showed minimal effect on patient survival, still CT had the greatest effect if introduced as early as possible (HR: 0.0624; P \u003C 0.0001). The integrative IMTs in the presented form have mild impact on gastrointestinal cancer patients’ survival, however, we observed its benefit in PC, which warrants further investigations.  \nGastrointestinal cancers account for 25. 8% and 35.4% of all new cancer cases and cancer-related deaths, respectively1. To date, surgical resection (if possible) and chemotherapy/chemoradiotherapy and/or biological/ targeted therapies are the gold standards for their treatment, however, despite all the efforts in the latest drug development and state-of-the-art surgical methods, the 5-year survival rate of advanced stage gastrointestinal cancers is still under 15%2. In the last decades, a new trend in the treatment of cancers has emerged that takes advantage of the immune system and fights cancer by reactivating the body’s natural immunity. It is suggested, that based on the amount ofT-cell-infiltration, immunologically “cold” and “hot” tumors can be distinguished3.“Hot” tumors are known to have a high level of intratumoral infiltrating T-cells, a high level of tumor mutational burden, and a less immunosuppressive tumor microenvironment. In contrast,“cold” tumors have a low level or no T-cell infiltration at all, low tumor mutational burden, and a highly immunosuppressive tumor microenvironment3–7. The immunosuppression largely occurs through immune checkpoint molecules, which are expressed by the tumor itself helping it escape the immune surveillance mechanisms2. The majority of gastrointestinal cancers are known to be “cold” tumors2–4, and only a very limited number with specific phenotypes are  \n1Dr. Kleef Medical Center, 1030 Vienna, Austria. 2Division of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, Budapest 1082, Hungary. 3Department of Internal Medicine and Hematology, Semmelweis University, Budapest 1088, Hungary. 4Department of Surgery, Transplantation and Gastroenterology,  \nSemmelweis University, Budapest 1082, Hungary.* email: [szasz.attila.marcell@semmelweis.hu](szasz.attila.marcell@semmelweis.hu)  \n[www. nature.com/scientificreports/](www. nature.com/scientificreports/)  \n“hot” and respond well to immune checkpoint inhibitor (ICI) therapy3. Immunotherapy using ICIs in the “hot”subtypes is part of the standard of care. Moreover, numerou","cbCaikpZTXN7tJD9","https://ap.wps.com/l/cbCaikpZTXN7tJD9","pdf",1761834,12,"English","# Introduction\n## Tumor immune microenvironment and ICI rationale\n## Off-label integrative oncology approaches\n# Results\n## Survival comparisons between IMT and CT","[{\"question\":\"What was compared in the study for gastrointestinal cancer patients?\",\"answer\":\"The study compared integrative immunomodulatory treatments (IMT) with conventional chemo(radio)therapy (CT) in advanced/metastatic gastrointestinal cancer patients.\"},{\"question\":\"Which IMT approach showed the most positive effect on overall survival?\",\"answer\":\"Locoregional modulated electro-hyperthermia showed the most positive effect on overall survival among the IMTs evaluated.\"},{\"question\":\"How did CT versus IMT perform in patient survival overall and by subgroup?\",\"answer\":\"Overall, IMTs showed minimal effect on survival, while CT had the greatest effect when introduced as early as possible. IMT was superior to CT in pancreatic cancer, while only modest effects were detected in colorectal cancer.\"}]","Comparison of the effectiveness of integrative immunomodulatory treatments and conventional therapies on the survival of selected gastrointestinal cancer patients | PDF",1790261781]