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This randomized phase II trial assigned patients to third-generation narrow-band imaging (3G-NBI), texture and color enhancement imaging (TXI), or high-definition white-light imaging (WLI) to evaluate new gastric neoplasm lesion detection. Primary outcomes assessed gastric neoplasm detection rate during primary observation, with missed-lesion rate, early gastric cancer detection rate, and positive predictive value as secondary endpoints. Among 901 patients, detection rates were 7.3% (3G-NBI), 5.0% (TXI), and 5.6% (WLI), supporting 3G-NBI as the more promising modality for gastric neoplasm detection.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comparison-of-effective-imaging-modalities-for-detecting-gastric-neoplasms-a-randomized-3-arm-phase-ii-trial/329081/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comparison-of-effective-imaging-modalities-for-detecting-gastric-neoplasms-a-randomized-3-arm-phase-ii-trial/329081.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the primary purpose of the randomized phase II trial?","Question",{"text":112,"@type":113},"To identify the most promising imaging modality for detecting gastric neoplasms using 3G-NBI and TXI, compared with WLI.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients assigned and what were the intervention groups?",{"text":117,"@type":113},"Patients undergoing scheduled or preoperative surveillance endoscopy were randomly assigned to 3G-NBI, TXI, or WLI groups.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key findings on gastric neoplasm detection rates?",{"text":121,"@type":113},"GN detection rates were 7.3% for 3G-NBI, 5.0% for TXI, and 5.6% for WLI, with 3G-NBI outperforming the others overall.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329081,1790038101,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","2010 ARTICLE  \n| INTRODUCTION: The early detection of gastric neoplasms (GNs) leads to favorable treatment outcomes. The latest endoscopic system, EVIS X1, includes third-generation narrow-band imaging (3G-NBI), texture and color enhancement imaging (TXI), and high-definition white-light imaging (WLI) . Therefore, this randomized phase II trial aimed to identify the most promising imaging modality for GN detection using 3G-NBI and TXI.\u003Cbr>METHODS: Patients with scheduled surveillance endoscopy after a history of esophageal cancer or GN or\u003Cbr>preoperative endoscopy for known esophageal cancer or GN were randomly assigned to the 3G-NBI, TXI, or WLI groups. Endoscopic observations were performed to detect new GN lesions, and all suspected lesions were biopsied. The primary endpoint was the GN detection rate during primary observation. Secondary endpoints were the rate of missed GNs, early gastric cancer detection rate, and positive predictive value for a GN diagnosis. The decision rule had a higher GN detection rate between 3G-NBI and TXI, outperforming WLI by > 1.0% .\u003Cbr>RESULTS: Finally, 901 patients were enrolled and assigned to the 3G-NBI, TXI, and WLI groups (300, 300, and\u003Cbr>301 patients, respectively) . GN detection rates in the 3G-NBI, TXI, and WLI groups were 7.3, 5.0, and 5.6%, respectively. The rates of missed GNs were 1.0, 0.7, and 1.0%, the detection rates of early gastric cancer were 5.7, 4.0, and 5.6%, and the positive predictive values for the diagnosis of GN were\u003Cbr>36.5, 21.3, and 36.8% in the 3G-NBI, TXI, and WLI groups, respectively.\u003Cbr>DISCUSSION: Compared with TXI and WLI, 3G-NBI is a more promising modality for GN detection.\u003Cbr>KEYWORDS: gastric cancer; image-enhanced endoscopy; lesion detection |  |\n| --- | --- |\n| Am J Gastroenterol 2024;119:2010–2018. [https://doi.org/10.14309/ajg.0000000000002871](https://doi.org/10.14309/ajg.0000000000002871) |  |\n| INTRODUCTION\u003Cbr>Gastric cancer (GC) is the fourth most common type of cancer worldwide. Moreover, GC’s early detection has been increasing owing to nationwide screening systems in Japan and Korea (1,2) . In certain cases, histopathological differentiation between gastric adenoma and early GC(EGC)is challenging. Approximately15% of gastric lesions initially diagnosed as adenomas by endoscopic biopsy are upgraded to GC after endoscopic resection (3) . Furthermore, gastric adenomas gradually increase in size and become cancerous during follow-up, and some institutions treat | gastric adenomas endoscopically (4) . Thus, early gastric neoplasm(GN)detection, including EGCand gastric adenomas, isan ideal strategy for maximizing GC survival rates. However, endoscopic observation using white-light imaging (WLI) (5), the current standard imaging modality, is unsatisfactory because of missed lesions, with room for improvement (6) .\u003Cbr>Endoscopic observation using narrow-band imaging (NBI) is the current standard imaging method for detecting superficial head, neck, and esophageal cancers, based on the positive results of a randomized controlled trial (RCT) comparing WLI and first- |\n\nSTOMACH  \nComparison of Effective Imaging Modalities for Detecting Gastric Neoplasms: A Randomized 3-Arm Phase II Trial  \nTomohiro Kadota, MD, PhD1, Seiichiro Abe, MD, PhD2, Noriya Uedo, MD, PhD3, Hisashi Doyama, MD, PhD4, Yasuaki Furue, MD, PhD5 ,  \nManabu Muto, MD, PhD6, Satoru Nonaka, MD, PhD2, Hiroyuki Takamaru, MD, PhD2, Tatsuro Murano, MD, PhD1 , Keiichiro Nakajo, MD, PhD 1, Yasuhiro Tani, MD3, Yuki Okubo, MD3, Azusa Kawasaki, MD4, Naohiro Yoshida, MD, PhD4 , Akinori Watanabe, MD, PhD5, Chikatoshi Katada, MD, PhD5 ,6, Masashi Tamaoki, MD, PhD6, Akira Yokoyama, MD, PhD6 , Hideki Furuya, Diploma7, Takashi Ikeno, PhD7, Masashi Wakabayashi, MSc8 and Tomonori Yano, MD, PhD1  \n1Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan; 2Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan; 3Department of Gastrointestinal Oncology, Osaka In","cbCainTvDr5b5mUY","https://ap.wps.com/l/cbCainTvDr5b5mUY","pdf",509162,"English","# Introduction\n# Methods\n# Results\n# Discussion","[{\"question\":\"What was the primary purpose of the randomized phase II trial?\",\"answer\":\"To identify the most promising imaging modality for detecting gastric neoplasms using 3G-NBI and TXI, compared with WLI.\"},{\"question\":\"How were patients assigned and what were the intervention groups?\",\"answer\":\"Patients undergoing scheduled or preoperative surveillance endoscopy were randomly assigned to 3G-NBI, TXI, or WLI groups.\"},{\"question\":\"What were the key findings on gastric neoplasm detection rates?\",\"answer\":\"GN detection rates were 7.3% for 3G-NBI, 5.0% for TXI, and 5.6% for WLI, with 3G-NBI outperforming the others overall.\"}]","Comparison of Effective Imaging Modalities for Detecting Gastric Neoplasms - A Randomized 3-Arm Phase II Trial | PDF",1789982334,23]