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This retrospective study evaluates 356 patients divided into ampulla of Vater cancer (AVC) and duodenal papilla cancer (DPC). Clinical and perioperative data were analyzed using Kaplan–Meier survival curves and univariate plus multivariate models to identify independent overall survival (OS) risk factors and assess the impact of adjuvant therapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comparison-of-clinical-characteristics-and-prognostic-factors-in-two-site-specific-categories-of-ampullary-cancer-original-article/332681/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comparison-of-clinical-characteristics-and-prognostic-factors-in-two-site-specific-categories-of-ampullary-cancer-original-article/332681.png","ImageObject",300,407,{"name":92,"@type":93},"Sage","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How were patients grouped in this study?","Question",{"text":112,"@type":113},"Patients were divided into ampulla of Vater cancer (AVC) and duodenal papilla cancer (DPC) based on gross and microscopic findings.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What differences in overall survival were observed between AVC and DPC?",{"text":117,"@type":113},"Overall survival for DPC patients was 58.90 ± 38.74 months, significantly longer than 44.31 ± 35.90 months for AVC patients (P \u003C 0.01).",{"name":119,"@type":110,"acceptedAnswer":120},"Which factors were independent risk factors for overall survival, and how did adjuvant therapy perform?",{"text":121,"@type":113},"For AVC, independent OS risk factors included preoperative albumin level, total bilirubin level, and number of positive lymph nodes. For DPC, OS risk factors included age, tumor size, number of positive lymph nodes, and adjuvant treatment; adjuvant therapy significantly improved OS for DPC but not for AVC.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332681,1790843931,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},687197207057,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2024 October 21; 30(39): 4281-4294  \nDOI: 10.3748/wjg.v30.i39.4281 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nORIGINAL ARTICLE  \nRetrospective Study  \nComparison of clinical characteristics and prognostic factors in two site-specific categories of ampullary cancer  \nJing-Zhao Zhang, Zhi-Wei Zhang, Xin-Yi Guo, Deng-Sheng Zhu, Xiao-Rui Huang, Ming Cai, Tong Guo, YaHong Yu  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B, Grade C, Grade C  \nNovelty: Grade B, Grade B, Grade C  \nCreativity or Innovation: Grade B, Grade B, Grade C  \nScientific Significance: Grade A, Grade B, Grade B  \nP-Reviewer: Kumar R; Yang L  \nReceived: May 9, 2024  \nRevised: September 13, 2024  \nAccepted: September 20, 2024  \nPublished online: October 21, 2024  \nProcessing time: 155 Days and 9.8 Hours  \nJing-Zhao Zhang, Zhi-Wei Zhang, Xin-Yi Guo, Deng-Sheng Zhu, Xiao-Rui Huang, Ming Cai, Tong Guo, Ya-Hong Yu, Department of Biliopancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei Province, China  \nCo-first authors: Jing-Zhao Zhang and Zhi-Wei Zhang.  \nCo-corresponding authors: Tong Guo and Ya-Hong Yu.  \nCorresponding author: Ya-Hong Yu, MD, Professor, Department of Biliopancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jie Fang Avenue, Wuhan 430000, Hubei Province, [China.](China. yuyahong615@sina.com)[ yuyahong615@sina.com](China. yuyahong615@sina.com)  \nAbstract  \nBACKGROUND  \nAmpullary cancer is a relatively rare malignant tumor in the digestive system. Its incidence has increased in recent years. As for now, its biological characteristics have not been fully clarified. Recent studies have primarily focused on the histological classification and genetic changes, but there are fewer investigations into the differences among site-specific subgroups. The clinicopathological characteristics of ampullary cancer occurring in different positions have not been elucidated. Furthermore, the role of adjuvant therapy in the treatment of patients with ampullary cancer remains controversial.  \nAIM  \nTo study the clinicopathological features of the two site-specific subgroups of ampullary cancer and explore the factors affecting prognosis.  \nMETHODS  \nA total of 356 patients who met the inclusion and exclusion criteria were enrolled. Patients were divided into ampulla of Vater cancer (AVC) and duodenal papilla cancer (DPC) based on the gross and microscopic findings. Baseline data, admission examination results, and perioperative outcomes were collected and analyzed. The Kaplan-Meier curve was used for survival analysis. Univariate and multivariate analysis was performed to explore the independent risk factors affecting the overall survival (OS) of both groups.  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 4281 October 21, 2024  Volume 30  Issue 39   \nZhang JZ et al. Comparison of two site-specific ampullary cancer  \nRESULTS  \nThe preoperative total bilirubin level in patients with AVC was significantly higher than those with DPC (P = 0.04) . The OS for patients with DPC was 58.90 ± 38.74 months, significantly longer than 44.31 ± 35.90 months for patients with AVC (P \u003C 0.01). The independent risk factors affecting the OS of AVC included: Preoperative albumin level (P = 0.009), total bilirubin level (P = 0.017), and number of positive lymph nodes (P = 0.005) . For DPC, risk factors included: Age (P = 0.004), tumor size (P = 0.023), number of positive lymph nodes (P = 0.010) and adjuvant treatment (P = 0.020). Adjuvant therapy significantly improved the OS rate ","cbCaigotqAn5fTPj","https://ap.wps.com/l/cbCaigotqAn5fTPj","pdf",1087089,15,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n# Core Tip\n# Citation","[{\"question\":\"How were patients grouped in this study?\",\"answer\":\"Patients were divided into ampulla of Vater cancer (AVC) and duodenal papilla cancer (DPC) based on gross and microscopic findings.\"},{\"question\":\"What differences in overall survival were observed between AVC and DPC?\",\"answer\":\"Overall survival for DPC patients was 58.90 ± 38.74 months, significantly longer than 44.31 ± 35.90 months for AVC patients (P \\u003c 0.01).\"},{\"question\":\"Which factors were independent risk factors for overall survival, and how did adjuvant therapy perform?\",\"answer\":\"For AVC, independent OS risk factors included preoperative albumin level, total bilirubin level, and number of positive lymph nodes. For DPC, OS risk factors included age, tumor size, number of positive lymph nodes, and adjuvant treatment; adjuvant therapy significantly improved OS for DPC but not for AVC.\"}]","Comparison of clinical characteristics and prognostic factors in two site-specific categories of ampullary cancer - Original Article | PDF",1789999062,38]