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Randomized controlled trials were identified through searches of CNKI, PubMed, and the Cochrane Library up to July 2024, with study quality appraised via Cochrane risk of bias tools and statistical synthesis conducted using RevMan 5.3. Results synthesize pooled relative risks across outcomes including respiratory depression, dizziness, and postoperative nausea and vomiting.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comparison-of-adverse-reactions-between-remimazolam-and-propofol-in-hysteroscopic-surgery-in-mainland-china-a-meta-analysis-and-systematic-review/444172/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comparison-of-adverse-reactions-between-remimazolam-and-propofol-in-hysteroscopic-surgery-in-mainland-china-a-meta-analysis-and-systematic-review/444172.png","ImageObject",300,407,{"name":92,"@type":93},"Nguyễn Văn Học","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the aim of this meta-analysis?","Question",{"text":112,"@type":113},"To compare adverse reactions between remimazolam and propofol in hysteroscopic anesthesia and evaluate the efficacy of remimazolam in alleviating adverse reactions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which databases and time range were searched?",{"text":117,"@type":113},"The review searched CNKI, PubMed, and the Cochrane Library, screening literature published until July 2024.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the pooled results show about adverse reactions?",{"text":121,"@type":113},"Remimazolam showed lower risks versus propofol for respiratory depression and dizziness, and reduced postoperative nausea and vomiting overall, while anesthesia recovery time differences were not statistically significant.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},444172,1790885175,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1374402739827,"https://ap-avatar.wpscdn.com/avatar/14000c97e7351f1a627?x-image-process=image/resize,m_fixed,w_180,h_180&k=1787885694763230660","Wiley  \nAnesthesiology Research and Practice Volume 2026, Article ID 4206976, 9 pages [https://doi.org/10.1155/anrp/4206976](https://doi.org/10.1155/anrp/4206976)  \nReview Article  \nComparison of Adverse Reactions Between Remimazolam and Propofol in Hysteroscopic Surgery in Mainland China: A Meta-Analysis and Systematic Review  \nZirui Liu , Kexu Zhu , Zidong Zhao , and Qi Zeng   \nXiangya School of Medicine, Central South University, 172 Tongzipo Road, Yuelu District, Changsha 410013, Hunan, China Correspondence should be addressed to Zirui Liu; [davidliu2003@163.com](davidliu2003@163.com)  \nReceived 16 October 2024; Revised 12 December 2025; Accepted 16 December 2025  \nAcademic Editor: Srijoni Sengupta  \nCopyright © 2026 Zirui Liu et al. Anesthesiology Research and Practice published by John Wiley & Sons Ltd. Tis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \nBackground: Te purpose of this meta-analysis was to compare the adverse reactions of remimazolam and propofol in hysteroscopic anesthesia and to evaluate the efcacy of remimazolam in alleviating adverse reactions.  \nMethods: We conducted a database search using China National Knowledge Infrastructure (CNKI), PubMed, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing the use of remimazolam with propofol for hysteroscopy procedures. We extracted data on the occurrence of adverse reactions such as hypotension, respiratory depression, dizziness, nausea, and vomiting for meta-analysis. Literature published until July 2024 was screened from each database, and the quality of the included studies was assessed using the bias risk assessment tool recommended by Cochrane. Data analysis was performed using RevMan 5.3 software, developed by the Cochrane Collaboration in the United Kingdom.  \nResults: Te pooled results demonstrated signifcant diferences in favor of remimazolam when compared to propofol for procedural sedation. Patients receiving remimazolam showed a lower risk of respiratory depression (RR: 0.19; 95% CI: [0.11, 0.33]; I2 􀂈 0%; p \u003C 0.00001), dizziness (RR: 0.10; 95% CI: [0.04, 0.31]; I2 􀂈 0%; p \u003C 0.0001), and postoperative nausea and vomiting (RR: 0.60; 95% CI: [0.15, 2.46]; I2 􀂈 0%; p 􀂈 0.48) . No signifcant diferences were observed in anesthesia recovery time between theremimazolam and propofol groups (MD: − 0.07; 95% CI: [ − 0.18–1.04]; I2 􀂈 98%; p 􀂈 0.90) .  \nConclusion: Compared to propofol, remimazolam reduces the occurrence of hypotension, respiratory depression, dizziness, and postoperative nausea and vomiting in the anesthesia management of hysteroscopy procedures.  \nKeywords: anesthetic; hysteroscope; meta-analysis; propofol; remimazolam; surgery  \n1. Introduction  \nHysteroscopy is among the most common minimally invasive diagnostic and therapeutic techniques for uterine diseases [1, 2] . With the advancement of assisted reproductive technology and minimally invasive techniques, as well as increased patient demands for comfortable medical procedures, outpatient painless hysteroscopy is becoming increasingly common [3, 4] .  \nPropofol, combined with opioids, is commonly employed for sedation during hysteroscopic examinations  \n[5, 6] . Propofol ofers a rapid onset, convenient titration, and short half-life [7] . However, propofol use is associated with pain on injection, postoperative dizziness, and respiratory depression [8, 9] .  \nRemimazolam is a novel intravenous benzodiazepine. Like propofol, remimazolam has a rapid onset and short duration of action. Owing to its ester metabolism (similar toremifentanil), remimazolam does not accumulate in tissues and is metabolized independently of liver and kidney function. Remimazolam is widely used for both sedation as well as anesthesia induction and maintenance [10] . On July  \n2 Anesthesiology Research and Practice  \n2, 2020, the U.S.","cbCaielAHdMYaOu8","https://ap.wps.com/l/cbCaielAHdMYaOu8","pdf",543406,"English","# Introduction\n# Research Methods and Materials\n## Search Strategy and Selection Criteria\n## Eligibility Criteria\n# Results\n# Conclusion","[{\"question\":\"What is the aim of this meta-analysis?\",\"answer\":\"To compare adverse reactions between remimazolam and propofol in hysteroscopic anesthesia and evaluate the efficacy of remimazolam in alleviating adverse reactions.\"},{\"question\":\"Which databases and time range were searched?\",\"answer\":\"The review searched CNKI, PubMed, and the Cochrane Library, screening literature published until July 2024.\"},{\"question\":\"What did the pooled results show about adverse reactions?\",\"answer\":\"Remimazolam showed lower risks versus propofol for respiratory depression and dizziness, and reduced postoperative nausea and vomiting overall, while anesthesia recovery time differences were not statistically significant.\"}]","Comparison of Adverse Reactions Between Remimazolam and Propofol in Hysteroscopic Surgery in Mainland China - A Meta-Analysis and Systematic Review | PDF",1790707107,23]