[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331074-105":59,"doc-detail-331074-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","comparative-transcriptomic-study-on-the-ovarian-cancer-between-chicken-and-human","Comparative transcriptomic study on the ovarian cancer between chicken and human","","The laying hen serves as a spontaneous model of ovarian tumors, enabling cross-species insight into ovarian cancer biology. Using next-generation sequencing, researchers profiled microRNA and mRNA expression in 9 chicken ovarian cancers and 4 normal ovaries, integrating these results with six public RNA-seq or multi-omics datasets. Differentially expressed microRNAs and extensive gene expression shifts were identified, alongside abnormal signaling across cancer hallmarks, KEGG pathways, and GO pathways via GSEA. Conserved pathways and survival-associated genes were also defined, supporting model-animal studies and gene-targeted drug development.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comparative-transcriptomic-study-on-the-ovarian-cancer-between-chicken-and-human/331074/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comparative-transcriptomic-study-on-the-ovarian-cancer-between-chicken-and-human/331074.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are laying hens considered a useful model for ovarian cancer?","Question",{"text":112,"@type":113},"Laying hens naturally develop ovarian tumors, allowing investigation across disease progression from normal tissue to late-stage carcinoma and supporting study of molecular mechanisms relevant to humans.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What data and sequencing approaches were used in the comparative study?",{"text":117,"@type":113},"The study performed next-generation sequencing of microRNA and mRNA expression profiles in chicken ovarian cancers and normal ovaries, then compared and integrated findings with multiple public datasets including GSE246604 and others.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings in gene and pathway analyses?",{"text":121,"@type":113},"The analysis identified differentially expressed microRNAs and large sets of up- and down-regulated genes, with abnormal signaling observed across cancer hallmarks, KEGG pathways, and GO pathways using GSEA, including conserved pathways between species.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331074,1790194136,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Comparative transcriptomic study on the ovarian cancer between chicken  \nand human  \nGuoqiang Zhu,* ,y Xinglong Wang, * ,y Yajun Wang, * ,y Tianjiao Huang,* ,y Xiao Zhang,* ,y Jiliang He, * ,y Ningkun Shi, * ,y Juntao Chen,* ,y Jiannan Zhang,* ,y Mao Zhang,z and Juan Li* ,y, 1  \n*  \nKey laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China; yAnimal Disease Prevention and Food Safety Key Laboratory of Sichuan  \nProvince, College of Life Sciences, Sichuan University, Chengdu, China; and zDivision of Vascular Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People ’s Hospital, School of Medicine, University of Electronic  \nScience and Technology of China, Chengdu, 610072, China  \nABSTRACT The laying hen is the spontaneous model of ovarian tumor. A comprehensive comparison based on RNA-seq from hens and women may shed light on the molecular mechanisms of ovarian cancer. We performed next-generation sequencing of microRNA and mRNA expression profiles in 9 chicken ovarian cancers and 4 normal ovaries, which has been deposited in GSE246604 . Together with 6 public datasets (GSE21706, GSE40376, GSE18520, GSE27651, GSE66957, TCGA-OV), we conducted a comparative transcriptomics study between chicken and human. In the present study, miR-451, miR- 2188-5p, and miR-10b-5p were differentially expressed in normal ovaries, early-and late-stage ovarian cancers. We also disclosed 499 up-regulated genes and 1,061 down-regulated genes in chicken ovarian cancer. The molecular signals from 9 cancer hallmarks, 25 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and 369 Gene  \nOntology (GO) pathways exhibited abnormalities in ovarian cancer compared to normal ovaries via Gene Set Enrichment Analysis (GSEA) . In the comparative analysis across species, we have uncovered the conservation of 5 KEGG and 76 GO pathways between chicken and human including the mismatch repair and ECM receptor interaction pathways. Moreover, a total of 174 genes contributed to the core enrichment for these KEGG and GO pathways were identified. Among these genes, the 22 genes were found to be associated with overall survival inpatients with ovarian cancer. In general, we revealed the microRNA profiles of ovarian cancers in hens and updated the mRNA profiles previously derived from microarrays. And we also disclosed the molecular pathways and core genes of ovarian cancer shared between hens and women, which informs model animal studies and gene-targeted drug development.  \nKey words: ovarian cancer, transcriptome analysis, miRNA, chicken, human  \n2024 Poultry Science 103:104021  \n[https://doi.org/10.1016/j.psj.2024.104021](https://doi.org/10.1016/j.psj.2024.104021)  \nINTRODUCTION  \nOvarian cancer is a highly fatal gynecologic malignancy and ranks as the 7th leading cause of cancerrelated mortality among women worldwide. The 5-year survival rate for ovarian cancer remains alarmingly low at just 46%(Doherty, et al., 2017; Gaona-Luviano, et al., 2020) . In 2020, there were approximately 313,959 new cases of ovarian cancer globally, leading to over 207,000 fatalities (Gallicchio, et al., 2020; Reid, 2020; Webb and Jordan, 2024) . Treatment of ovarian cancer typically involves radical surgery, followed by platinum-  \n􀀁 2024 Published by Elsevier Inc. on behalf of Poultry Science Association Inc. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/)).  \nReceived April 12, 2024 .  \nAccepted June 19, 2024 .  \n1Corresponding author: [lijuanscuhk@163.com](lijuanscuhk@163.com)  \nbased chemotherapy and angiogenesis inhibitors, such as bevacizumab (Bookman, et al., 2009; Marchetti, et al., 2019) . Since the clinical manifestation at an early stage are hard to be detected, 70% patients can only be diagnosed at a late stage, leading to the relatively low 5-year survival rate ","cbCaipK4Ev75e6a7","https://ap.wps.com/l/cbCaipK4Ev75e6a7","pdf",6032584,16,"English","# Abstract\n# Introduction","[{\"question\":\"Why are laying hens considered a useful model for ovarian cancer?\",\"answer\":\"Laying hens naturally develop ovarian tumors, allowing investigation across disease progression from normal tissue to late-stage carcinoma and supporting study of molecular mechanisms relevant to humans.\"},{\"question\":\"What data and sequencing approaches were used in the comparative study?\",\"answer\":\"The study performed next-generation sequencing of microRNA and mRNA expression profiles in chicken ovarian cancers and normal ovaries, then compared and integrated findings with multiple public datasets including GSE246604 and others.\"},{\"question\":\"What were the main findings in gene and pathway analyses?\",\"answer\":\"The analysis identified differentially expressed microRNAs and large sets of up- and down-regulated genes, with abnormal signaling observed across cancer hallmarks, KEGG pathways, and GO pathways using GSEA, including conserved pathways between species.\"}]","Comparative transcriptomic study on the ovarian cancer between chicken and human | PDF",1789991617]