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Materials and Methods: Patients aged 18–65 with chronic periodontitis and ≥3 non‑adjacent pockets (5–10 mm) were enrolled; 75 sites were allocated to SRP alone, SRP+T‑PRF, or SRP+tetracycline fibers. Clinical parameters (PI, mSBI, PPD, RAL) were assessed at baseline, 1 week, and 3 months using standardized probes and stents. Results: All groups improved significantly by 3 months, while intergroup differences emerged at 3 months favoring tetracycline fibers in mSBI and PPD. Conclusion: Both adjuncts produced significant clinical improvements.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comparative-evaluation-of-subgingivally-delivered-titanium-prepared-platelet-rich-fibrin-tprf-and-tetracycline-fibers-a-randomized-controlled-clinical-trial/460369/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comparative-evaluation-of-subgingivally-delivered-titanium-prepared-platelet-rich-fibrin-tprf-and-tetracycline-fibers-a-randomized-controlled-clinical-trial/460369.png","ImageObject",300,407,{"name":92,"@type":93},"LangkahRina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the primary aim of the study?","Question",{"text":112,"@type":113},"To evaluate and compare the clinical effectiveness of subgingivally delivered T‑PRF and tetracycline fibers as adjuncts to scaling and root planning in periodontitis patients.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were participants and sites allocated in the trial?",{"text":117,"@type":113},"Patients aged 18–65 with chronic periodontitis were enrolled, and 75 sites were randomly allocated into three groups: SRP alone, SRP with T‑PRF, and SRP with tetracycline fibers.",{"name":119,"@type":110,"acceptedAnswer":120},"Which treatment showed the greatest improvement at 3 months?",{"text":121,"@type":113},"At 3 months, mSBI and PPD differed significantly between groups, with tetracycline fibers generally showing the greatest improvement, supported by specific post‑hoc differences between Group A and Group C for those parameters.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},460369,1790758311,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":129,"read_time":39,"preview_page_count":4},962090893776,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Original Research  \nComparative Evaluation of Subgingivally Delivered Titanium Prepared Platelet Rich Fibrin (T‑PRF) and Tetracycline Fibers as an Adjunct to Scaling and Root Planning in Treatment of Periodontitis: A Randomized Controlled Clinical Trial  \nChirag Gupta1, Swati Agarwal2, Ellora Madan2, Kratee Sharma2, Nuzla Agha2, Karnika Agrawal2  \n1Post Graduate  \nStudent, Department of Periodontology and Oral Implantology, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh, India, 2Department of Periodontology and Oral Implantology, Kothiwal Dental College and Research Centre, Moradabad,  \nUttar Pradesh, India  \nSubmitted: 09‑Aug‑2025  \nRevised: 16‑Aug‑2025  \nAccepted: 25‑Aug‑2025  \nPublished: 17‑Dec‑2025  \nAbstract  \nAim: The present study aimed to evaluate and compare the clinical effectiveness of subgingivally delivered T‑PRF with subgingivally delivered tetracycline fibers over scaling and root planning in patients with periodontitis. Materials and Methods: This single‑center, randomized controlled clinical trial enrolled patients aged 18–65 years with chronic periodontitis and at least three non‑adjacent periodontal pockets of ≥5 mm and ≤10 mm. Seventy‑five sites were randomly allocated to three groups: Group A (SRP alone with saline irrigation), Group B (SRP with subgingival administration of T‑PRF), and Group C (SRP with subgingival placement of tetracycline fibers) . Clinical parameters (PI, mSBI, PPD, RAL) were recorded at baseline, 1 week, and 3 months using calibrated examiners and standardized methods, including customised acrylic occlusalstents and a UNC 15 probe. Intragroup and intergroup comparisons of clinical parameters were performed using appropriate statistical tests. Results: Intragroup analysis showed statistically significant reductions in PI, mSBI, and PPD, and a significant gain in RAL in all three groups from baseline to 3 months (P \u003C 0.01) . Intergroup comparisons at baseline were not significant for all parameters. At 3 months, mSBI and PPD showed significant differences between groups, with Group C (Tetracycline fibers) generally demonstrating the greatest improvement, although post‑hoc analysis revealed specific significant differences between Group A and Group C for mSBI and PPD. Conclusion: Both subgingivally delivered T‑PRF and tetracycline fibers as adjuncts to SRP resulted in significant clinical improvements in patients with chronic periodontitis.  \nKeywords: Clinical trial, local drug delivery, periodontitis, scaling and root planning, tetracycline fibres, titanium‑prepared platelet rich fibrin (T‑PRF)   \nIntroduction  \neriodontal disease (PD)  \nPimmune‑mediated inflammatory  \nis a condition  \nchronic marked  \nby the destruction of the soft tissue attachment and supporting alveolar bone, leading to periodontal pocket formation and/or gingival recession.[1] It results from microbial colonization by pathogenic microorganisms and, if untreated, can cause tooth mobility, displacement, and eventual loss, thereby impairing mastication, nutrition, and overall health. Management options  \n\n| Access this article online |  |\n| --- | --- |\n| Quick Response Code:\u003Cbr>| Website: [https://journals.lww.com/jpbs](https://journals.lww.com/jpbs) |\n|  | DOI: 10.4103/jpbs.jpbs_1436_25 |\n\ninclude nonsurgical therapies such as scaling and root planning (SRP), adjunctive antimicrobial therapy, and surgical interventions. SRP is considered the gold standard for nonsurgical management of chronic periodontitis[2]; however, its effectiveness can be limited  \nAddress for correspondence: Dr. Chirag Gupta, Post Graduate Student, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh, India.  \nE-mail: [drchiragguptasvsu@gmail.com](drchiragguptasvsu@gmail.com)  \nThis is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License (CC BY-NC-ND), where it is permissible to download and share the work provided it is properly c","cbCaiiArvZAs8tj8","https://ap.wps.com/l/cbCaiiArvZAs8tj8","pdf",602403,"English","# Abstract\n# Introduction\n# Materials and Methods","[{\"question\":\"What was the primary aim of the study?\",\"answer\":\"To evaluate and compare the clinical effectiveness of subgingivally delivered T‑PRF and tetracycline fibers as adjuncts to scaling and root planning in periodontitis patients.\"},{\"question\":\"How were participants and sites allocated in the trial?\",\"answer\":\"Patients aged 18–65 with chronic periodontitis were enrolled, and 75 sites were randomly allocated into three groups: SRP alone, SRP with T‑PRF, and SRP with tetracycline fibers.\"},{\"question\":\"Which treatment showed the greatest improvement at 3 months?\",\"answer\":\"At 3 months, mSBI and PPD differed significantly between groups, with tetracycline fibers generally showing the greatest improvement, supported by specific post‑hoc differences between Group A and Group C for those parameters.\"}]","Comparative Evaluation of Subgingivally Delivered Titanium Prepared Platelet Rich Fibrin (T‑PRF) and Tetracycline Fibers - A Randomized Controlled Clinical Trial | PDF"]