[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330841-105":59,"doc-detail-330841-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","comparative-analysis-through-propensity-score-matching-in-thyroid-cancer-unveiling-the-impact-of-multiple-malignancies","Comparative analysis through propensity score matching in thyroid cancer - unveiling the impact of multiple malignancies","","Retrospective analysis evaluated malignancies associated with thyroid cancer and compared survival between patients with a solitary tumor and those with multiple primary neoplasms (MPN). Data from King Hussein Cancer Center included 563 thyroid cancer patients, with 30 presenting thyroid malignancy as part of MPN. Propensity score matching (1:3) enrolled 90 patients with only a primary thyroid malignancy. Hematologic and breast cancers were frequently observed. MPN patients were older, had higher BMI and thyroglobulin antibody levels, and showed stronger family cancer history, with worse 5-year survival.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comparative-analysis-through-propensity-score-matching-in-thyroid-cancer-unveiling-the-impact-of-multiple-malignancies/330841/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comparative-analysis-through-propensity-score-matching-in-thyroid-cancer-unveiling-the-impact-of-multiple-malignancies/330841.png","ImageObject",300,407,{"name":92,"@type":93},"Violet","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study objective regarding thyroid cancer and multiple primary neoplasms?","Question",{"text":112,"@type":113},"To explore malignancies linked to thyroid cancer and compare survival between patients with a solitary tumor and those with multiple primary neoplasms (MPN).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients selected for comparison?",{"text":117,"@type":113},"Among 563 thyroid cancer patients at King Hussein Cancer Center, 30 had thyroid malignancy as part of MPN, and propensity score matching (1:3) matched them with 90 patients who had only a primary thyroid malignancy.",{"name":119,"@type":110,"acceptedAnswer":120},"What survival differences did the study find between MPN patients and those with a single tumor?",{"text":121,"@type":113},"MPN patients had worse 5-year survival (87% vs 100%, p \u003C 0.01), while no difference was observed in 5-year event-free survival between the groups.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330841,1790143550,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","TYPE Original Research PUBLISHED 04 June 2024  \nDOI 10.3389/fendo.2024.1366935  \nOPEN ACCESS  \nEDITED BY  \nTheodora Pappa,  \nBrigham and Women’s Hospital and Harvard Medical School, United States  \nREVIEWED BY  \nKyriakos Vamvakidis,  \nHenry Dunant Hospital, Greece Akira Sugawara,  \nTohoku University, Japan Marta Villanova,  \nSan Raffaele Hospital (IRCCS), Italy Francesca Perticone,  \nVita-Salute San Raffaele University, Italy  \n*CORRESPONDENCE Akram Al-Ibraheem  \n [aibraheem@khcc.jo](aibraheem@khcc.jo);  \n [akramalibrahim@gmail.com](akramalibrahim@gmail.com)  \nRECEIVED 07 January 2024  \nACCEPTED 22 May 2024  \nPUBLISHED 04 June 2024  \nCITATION  \nAl-Ibraheem A, Abdlkadir AS, Al-Adhami DA, Lopci E, Al-Omari A, Al-Masri M, Yousef Y, Al-Hajaj N, Mohamad I, Singer S and Sykiotis GP (2024) Comparative analysis through propensity score matching in thyroid cancer: unveiling the impact of multiple malignancies.  \nFront. Endocrinol. 15:1366935 .  \ndoi: 10.3389/fendo.2024.1366935  \nCOPYRIGHT  \n© 2024 Al-Ibraheem, Abdlkadir, Al-Adhami, Lopci, Al-Omari, Al-Masri, Yousef, Al-Hajaj, Mohamad, Singer and Sykiotis. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nComparative analysis through propensity score matching in thyroid cancer: unveiling the impact of multiple malignancies  \nAkram Al-Ibraheem 1,2*, Ahmed Saad Abdlkadir 1,  \nDhuha Ali Al-Adhami 1, Egesta Lopci 3, Amal Al-Omari 4, Mahmoud Al-Masri 5, Yacoub Yousef 5, Nabeela Al-Hajaj 1, Issa Mohamad 6, Susanne Singer 7 and Gerasimos P. Sykiotis 8  \n1 Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan, 2 Division of Nuclear Medicine, Department of Radiology and Nuclear Medicine, the University of Jordan, Amman, Jordan, 3 Nuclear Medicine Unit, IRCCS– Humanitas Clinical and Research Hospital, Rozzano, Milan, Italy, 4Office of Scientific Affairs and Research (OSAR), King Hussein Cancer Center (KHCC), Amman, Jordan, 5 Department of Surgery, King Hussein Cancer Center (KHCC), Amman, Jordan,  \n6 Department of Radiation Oncology, King Hussein Cancer Center (KHCC), Amman, Jordan, 7 Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre Mainz, Mainz, Germany, 8 Department of Endocrinology, Diabetology and Metabolism, Vaud University Hospital Center (CHUV), Lausanne, Switzerland  \nBackground: The incidence of thyroid cancer is on the rise worldwide, with childhood exposure to radiation being the sole acknowledged catalyst for its emergence. Nonetheless, numerous other factors that may pose risks areawaiting thorough examination and validation. This retrospective study aims to explore the malignancies linked to thyroid cancer and contrast the survival rates of those afflicted with a solitary tumor versus those with multiple primary neoplasms (MPN) .  \nMethods: This retrospective study examined data from King Hussein Cancer Center (KHCC), Jordan. Among 563 patients diagnosed with thyroid cancer, 30 patients had thyroid malignancy as part of MPN. For a 1:3 propensity scorematched analysis, 90 patients with only a primary thyroid malignancy were also enrolled.  \nResults: Hematologic and breast malignancies were among the most frequent observed cancers alongside thyroid neoplasm. Patients who had MPN were diagnosed at older age, had higher body mass index and presented with higher thyroglobulin antibody levels (p \u003C 0 . 05 for each) . Additionally, MPN patient displayed a stronger family history for cancers (p= 0 . 002) . A median follow-up duration of 135 months unveiled that MPN patients faced a worse 5-year survival compared to their cou","cbCaigJQXVNCbeSZ","https://ap.wps.com/l/cbCaigJQXVNCbeSZ","pdf",858355,12,"English","# Background\n## Study aim\n# Methods\n## Study population and propensity score matching\n# Results\n## Cancer patterns\n## Clinical differences between groups\n## Survival outcomes\n# Conclusion","[{\"question\":\"What was the study objective regarding thyroid cancer and multiple primary neoplasms?\",\"answer\":\"To explore malignancies linked to thyroid cancer and compare survival between patients with a solitary tumor and those with multiple primary neoplasms (MPN).\"},{\"question\":\"How were patients selected for comparison?\",\"answer\":\"Among 563 thyroid cancer patients at King Hussein Cancer Center, 30 had thyroid malignancy as part of MPN, and propensity score matching (1:3) matched them with 90 patients who had only a primary thyroid malignancy.\"},{\"question\":\"What survival differences did the study find between MPN patients and those with a single tumor?\",\"answer\":\"MPN patients had worse 5-year survival (87% vs 100%, p \\u003c 0.01), while no difference was observed in 5-year event-free survival between the groups.\"}]","Comparative analysis through propensity score matching in thyroid cancer - unveiling the impact of multiple malignancies | PDF",1789990432]