[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-426036-105":59,"doc-detail-426036-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","comparative-analysis-of-sex-specific-aging","COMPARATIVE ANALYSIS OF SEX-SPECIFIC AGING","","Sex-specific aging varies across individuals and species, with women often showing longer average lifespans, yet exceptions exist where males live longer or where lifespan shows no sex difference despite other age-related divergences. The Integration Initiative: Sex, Aging, Genomics, and Evolution (IISAGE) connects researchers studying this naturally occurring variation to uncover mechanistic drivers of sex-specific aging and its evolutionary origins. IISAGE applies organismal, physiological, and genomics measurements across multiple model systems, using common methodologies to enable cross-species comparisons, including comparative transcriptomic analyses.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/comparative-analysis-of-sex-specific-aging/426036/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/comparative-analysis-of-sex-specific-aging/426036.png","ImageObject",300,407,{"name":92,"@type":93},"Putri","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does sex-specific aging refer to in the document?","Question",{"text":112,"@type":113},"Sex-specific aging describes differences between females and males in how aging occurs and manifests across individuals. It also notes that sex-specific patterns appear in many animal species.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does IISAGE aim to study sex-specific aging?",{"text":117,"@type":113},"IISAGE brings together researchers to exploit natural variation in sex-specific aging patterns, using organismal, physiological, and genomics measures. Common methodologies are used to support comparative studies across diverse species.",{"name":119,"@type":110,"acceptedAnswer":120},"What kinds of data and analyses are mentioned as part of IISAGE results?",{"text":121,"@type":113},"The document states that IISAGE uses organismal, physiological, and genomics measures, and that it presents results from several studies, including comparative transcriptomic analyses.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426036,1790829937,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},962085571259,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","450 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.1533  \nCOMPARATIVE ANALYSIS OF SEX-SPECIFIC AGING  \nNicole Riddle, University of Alabama at Birmingham, Alabama, United States  \nWomen and men show many differences in how they age, evident for example in the longer average lifespan seen in women. Sex-specific aging also occurs in many animal species. However, females do not always live longer. In some species males live longer than females, and in some species, there are no differences in lifespan between females and males despite other sex differences in aging. The Integration Initiative: Sex, Aging, Genomics, and Evolution (IISAGE) brings together researchers working in diverse species to exploit this naturally occurring variation in sex-specific patterns of aging to gain insights into the mechanistic basis of sex-specific aging and their evolution. The IISAGE team utilizes organismal, physiological, and genomics measures from various Drosophila species, moths and butterflies, fishes, geckos, turtles, snakes, bats, and mice. Using common methodologies allows us to carry out comparative studies across these diverse species. We present the results from several studies, including comparative transcriptomic analyses.","cbCaipxXVBj9WNEp","https://ap.wps.com/l/cbCaipxXVBj9WNEp","pdf",449405,"English","# Abstract\n## Sex-specific aging across humans and animals\n## IISAGE integration and research approach\n## Cross-species measurements and comparative transcriptomics","[{\"question\":\"What does sex-specific aging refer to in the document?\",\"answer\":\"Sex-specific aging describes differences between females and males in how aging occurs and manifests across individuals. It also notes that sex-specific patterns appear in many animal species.\"},{\"question\":\"How does IISAGE aim to study sex-specific aging?\",\"answer\":\"IISAGE brings together researchers to exploit natural variation in sex-specific aging patterns, using organismal, physiological, and genomics measures. Common methodologies are used to support comparative studies across diverse species.\"},{\"question\":\"What kinds of data and analyses are mentioned as part of IISAGE results?\",\"answer\":\"The document states that IISAGE uses organismal, physiological, and genomics measures, and that it presents results from several studies, including comparative transcriptomic analyses.\"}]","COMPARATIVE ANALYSIS OF SEX-SPECIFIC AGING | PDF",1790639178]