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Methods Use online prediction tools plus quantitative real-time PCR, western blotting, and immunohistochemistry to assess COMMD10 expression. Evaluate COMMD10 knockdown in GC cell lines and in vivo xenograft models, and examine links between COMMD10 and DNA damage using western blotting and immunofluorescence. Results COMMD10 is elevated in GC and associates with higher TNM stage, larger tumor size, and poor prognosis; knockdown suppresses proliferation, migration, invasion, induces cell-cycle arrest, raises apoptosis, and reduces cisplatin-induced DNA damage repair while activating ATM–p53 signaling. Conclusion COMMD10 supports DNA damage repair and genomic stability in GC, making it a potential therapeutic target.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/commd10-inhibited-dna-damage-to-promote-the-progression-of-gastric-cancer/330839/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/commd10-inhibited-dna-damage-to-promote-the-progression-of-gastric-cancer/330839.png","ImageObject",300,407,{"name":92,"@type":93},"Violet","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of this study on COMMD10 in gastric cancer?","Question",{"text":112,"@type":113},"To investigate how COMMD10 contributes to gastric cancer progression, focusing specifically on DNA damage and repair mechanisms.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the researchers evaluate COMMD10 expression and its functional effects?",{"text":117,"@type":113},"They used online prediction tools and experimental assays including quantitative real-time PCR, western blotting, and immunohistochemistry. They then tested COMMD10 knockdown in GC cell lines and in vivo xenograft tumor experiments.",{"name":119,"@type":110,"acceptedAnswer":120},"What happens to DNA damage repair and signaling when COMMD10 is knocked down?",{"text":121,"@type":113},"COMMD10 knockdown impedes DNA damage repair, intensifies DNA damage, and activates the ATM–p53 signaling pathway in gastric cancer cells and xenograft tissues.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330839,1790688012,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","Journal of Cancer Research and Clinical Oncology (2024) 150:305  \n[https://doi.org/10.1007/s00432-024-05817-z](https://doi.org/10.1007/s00432-024-05817-z)  \nCOMMD10 inhibited DNA damage to promote the progression of gastric cancer  \nXiaohua Liu1 · Xiaocheng Mao1 · Chao Zhu1 · Hongfei liu1 · Yangyang Fang1 · Tianmei Fu1 · Linwei Fan1 · Mengwei Liu1 · Ziqing Xiong1 · Hong Tang1 · Piaoping Hu1 · Aiping Le1  \nReceived: 15 February 2024 / Accepted: 22 May 2024 / Published online: 13 June 2024 © The Author(s) 2024  \nAbstract  \nPurpose The copper metabolism MURR1 domain 10 (COMMD10) plays a role in a variety of tumors. Here, we investigated its role in gastric cancer (GC) .  \nMethods Online prediction tools, quantitative real-time PCR, western blotting and immunohistochemistry were used to evaluate the expression of COMMD10 in GC. The effect of COMMD10 knockdown was investigated in the GC cell lines and in in vivo xenograft tumor experiments. Western blotting and immunofluorescence were used to explore the relationships between COMMD10 and DNA damage.  \nResults The expression of COMMD10 was upregulated in GC compared to that in para-cancerous tissue and correlated with a higher clinical TNM stage (P = 0.044) and tumor size (P = 0.0366). High COMMD10 expression predicted poor prognosis in GC. Knockdown of COMMD10 resulted in the suppression of cell proliferation, migration, and invasion, accompanied by cell cycle arrest and an elevation in apoptosis rate. Moreover, the protein expression of COMMD10 was decreased incisplatin-induced DNA-damaged GC cells. Suppression of COMMD10 impeded DNA damage repair, intensified DNA damage, and activated ATM–p53 signaling pathway in GC. Conversely, restoration of COMMD10 levels suppressed DNA damage and activation of the ATM-p53 signaling cascade. Additionally, knockdown of COMMD10 significantly restrained the growth of GC xenograft tumors while inhibiting DNA repair, augmenting DNA damage, and activating the ATM–p53 signaling pathway in xenograft tumor tissue.  \nConclusion COMMD10 is involved in DNA damage repair and maintains genomic stability in GC; knockdown ofCOMMD10 impedes the development of GC by exacerbating DNA damage, suggesting that COMMD10 may be new target for GC therapy.  \nKeywords COMMD10 · Gastric cancer · ATM-p53 · DNA damage repair  \nXiaohua Liu, Xiaocheng Mao and Chao Zhu contributed equally to this work.  \n* Piaoping Hu [piaoping_81@163.com](piaoping_81@163.com)  \n* Aiping Le[ndyfy00973@ncu.edu.cn](ndyfy00973@ncu.edu.cn)  \n1 Department of Blood Transfusion, Key Laboratory of Jiangxi Province for Transfusion Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 1519 Dongyue Avenue, Nanchang, Jiangxi, People’s Republic of China  \nIntroduction  \nGastric cancer (GC) had been responsible for 1 million new cases and 768,793,000 deaths in 2020, according to the 2022 Global Cancer Statistics (Siegel et al. 2022) . Despite advances in the treatment of GC, recurrence and progression remain common (Joshi and Badgwell 2021) . As the exact mechanisms of gastric carcinogenesis and development remain largely unknown, urgent efforts are needed to unravel the mechanisms of GC development and identify novel therapeutic targets to improve the survival of patients with GC.  \nThe copper metabolism MURR1 domain (COMMD) family was discovered in recent decades. It consists of 10 family members (COMMD1–COMMD10) and is characterized  \nby the presence of a highly conserved and unique motif named the COMM domain at the extreme carboxyl termini of the proteins (Maine and Burstein 2007), which serves as an interface for COMMD–COMMD protein interactions (Burstein et al. 2005). These members are highly conserved throughout evolution and share certain functional properties including the regulation of transcription factor NF-κB activity (Maine and Burstein 2007), immune response (Shirai et al. 2023), copper homeostasis (Corbee and Penning 2021), endosomal sorting (Healy et al. 20","cbCaitRYtGjtFDfU","https://ap.wps.com/l/cbCaitRYtGjtFDfU","pdf",8108249,16,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is the main purpose of this study on COMMD10 in gastric cancer?\",\"answer\":\"To investigate how COMMD10 contributes to gastric cancer progression, focusing specifically on DNA damage and repair mechanisms.\"},{\"question\":\"How did the researchers evaluate COMMD10 expression and its functional effects?\",\"answer\":\"They used online prediction tools and experimental assays including quantitative real-time PCR, western blotting, and immunohistochemistry. They then tested COMMD10 knockdown in GC cell lines and in vivo xenograft tumor experiments.\"},{\"question\":\"What happens to DNA damage repair and signaling when COMMD10 is knocked down?\",\"answer\":\"COMMD10 knockdown impedes DNA damage repair, intensifies DNA damage, and activates the ATM–p53 signaling pathway in gastric cancer cells and xenograft tissues.\"}]","COMMD10 inhibited DNA damage to promote the progression of gastric cancer | PDF",1789990430]