[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-383117-105":59,"doc-detail-383117-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","combined-larynx-large-cell-neuroendocrine-and-squamous-cell-carcinoma-a-case-report","Combined larynx large cell neuroendocrine and squamous cell carcinoma - a case report","","Laryngeal cancer ranks third among head and neck malignancies, with squamous cell carcinoma being the most common histologic subtype and neuroendocrine tumors remaining rare. This case report describes a composite metastatic tumor containing both squamous and large cell neuroendocrine components. Following a total laryngectomy, the patient received adjuvant treatment combining chemotherapy, radiotherapy, and immunotherapy, achieving a favorable treatment response despite the exceptional rarity of this entity.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/combined-larynx-large-cell-neuroendocrine-and-squamous-cell-carcinoma-a-case-report/383117/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/combined-larynx-large-cell-neuroendocrine-and-squamous-cell-carcinoma-a-case-report/383117.png","ImageObject",300,407,{"name":92,"@type":93},"Fans","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is this laryngeal tumor considered rare?","Question",{"text":112,"@type":113},"The report highlights that neuroendocrine tumors of the larynx are uncommon and that a composite tumor combining neuroendocrine and squamous cell histology is even rarer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What was the patient’s initial presentation and diagnostic workup?",{"text":117,"@type":113},"A 64-year-old male smoker presented with 3 months of hoarseness. Examination and laryngoscopy identified a left-sided mass, and microlaryngoscopy biopsy showed invasive squamous cell carcinoma.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatments did the patient receive and what outcome was reported?",{"text":121,"@type":113},"The patient underwent total laryngectomy with left neck dissection, followed by adjuvant postoperative therapy including chemo-, radio-, and immunotherapy. 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Combined larynx large cell neuroendocrine and squamous cell carcinoma: a case report. einstein (São Paulo) . 2023;21:eRC0618 .  \nCorresponding author:  \nFabio Pupo Ceccon  \nRua Afonso Braz 579, room 66/68  \nZip code: 04511-011, São Paulo, SP, Brazil  \nPhone: (55 11) 99405-0493  \n[Email: fpceccon@uol.com.br](Email: fpceccon@uol.com.br)  \nReceived on:  \nJune 7, 2023  \nAccepted on:  \nJuly 14, 2023  \nCopyright the authors  \nThis content is licensed  \nunder a Creative Commons Attribution 4.0 International License.  \nCASE REPORT  \nCombined larynx large cell neuroendocrine and squamous cell carcinoma: a case report  \nJuliana Hesse1, Leandro Aurélio Liporoni Martins2, Leonardo Haddad2, Fabio Pupo Ceccon2  \n1 Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.  \n2 Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.  \nDOI: 10.31744/einstein_journal/2023RC0618  \n❚ ABSTRACT  \nLaryngeal cancer ranks third among the most common head and neck neoplasms. The most common histological subtype is squamous cell carcinoma, and neuroendocrine tumors are rare. An even rarer entity is a composite tumor with both these histologies. This case reports a metastatic combined carcinoma of squamous cells and large neuroendocrine cells, presenting favorable response to treatment with a total laryngectomy followed by adjuvant therapy including chemo-, radio-, and immunotherapy.  \nKeywords: Laryngeal neoplasms; Carcinoma, neuroendocrine; Carcinoma, squamous cell; Head and neck neoplasms; Carcinoma, large cell  \n❚ INTRODUCTION  \nLaryngeal cancer ranks third among the most common head and neck neoplasms and affects more men than women. Treatment options generally negatively affect the patient’s quality of life. The primary risk factors for laryngeal cancer include alcohol and tobacco use, dietary habits, HPV infection, and occupational exposure.(1) Staging follows the tumor–node–metastasis system. Treatment and prognosis differ considerably according to the exact anatomical structure involved as well as the tumor’s histology. While the most common histological subtype is squamous cell carcinoma (SCC), neuroendocrine tumors are rare.(2) Infrequently, they might appear simultaneously.  \nHerein, we describe a rare laryngeal combined squamous cell and large cell neuroendocrine carcinoma (LCNEC) and the course of treatment.  \n❚ CASE REPORT  \nA 64-year-old male smoker sought medical assistance due to 3-month long hoarseness. Physical examination revealed a lump of level 2 at the left side of his neck (Figures 1A and 1B); laryngoscopy showed a single mass fixing the left vocal cord extending to the vestibular fold with vegetative and infiltrative components (Figures 1C and 1D) . Infraglottic lesions were not visualized.  \nMicrolaryngoscopy was performed to biopsy the tumor, resulting in an invasive squamous cell carcinoma. After discussing the therapeutic options, the patient chose to undergo surgery and adjuvant postoperative chemo/ radiotherapy.  \neinstein (São Paulo) . 2023;21:1-4  \nComplete laryngectomy with left neck dissection from levels 1 to 6 was performed in the same month. Stapler closure of the pharynx and primary tracheoesophageal prosthesis insertion were done. The patient had a favorable recovery and was discharged on the 10th day. One week later, he presented with a pharyngocutaneous fistula that was treated conservatively.  \nThe anatomopathological report demonstrated two primary tumors in the larynx: a predominant compound of grade 3 (high grade) LCNEC that displayed cellular anaplasia, evident nucleolus and high mitosis activity and another area of in situ and invasive SCC. These results allowed us to consider a combined carcinoma, with two components: squamous cell carcinoma and predomin","cbCaitYXcVEO7VyM","https://ap.wps.com/l/cbCaitYXcVEO7VyM","pdf",462916,"English","# Abstract\n# Introduction\n# Case report\n## Diagnosis and initial treatment choice\n## Surgery and postoperative course\n## Pathology findings and immunohistochemistry","[{\"question\":\"Why is this laryngeal tumor considered rare?\",\"answer\":\"The report highlights that neuroendocrine tumors of the larynx are uncommon and that a composite tumor combining neuroendocrine and squamous cell histology is even rarer.\"},{\"question\":\"What was the patient’s initial presentation and diagnostic workup?\",\"answer\":\"A 64-year-old male smoker presented with 3 months of hoarseness. Examination and laryngoscopy identified a left-sided mass, and microlaryngoscopy biopsy showed invasive squamous cell carcinoma.\"},{\"question\":\"What treatments did the patient receive and what outcome was reported?\",\"answer\":\"The patient underwent total laryngectomy with left neck dissection, followed by adjuvant postoperative therapy including chemo-, radio-, and immunotherapy. The case describes a favorable response to treatment.\"}]","Combined larynx large cell neuroendocrine and squamous cell carcinoma - a case report | PDF",1790254349]