[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-385315-105":59,"doc-detail-385315-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","combinational-gene-therapy-toward-cancer-with-nanoplatform-strategies-and-principles","Combinational Gene Therapy toward Cancer with Nanoplatform - Strategies and Principles","","Cancer poses a major threat to human health, and conventional modalities like chemotherapy and radiotherapy often show limited effectiveness while causing substantial side effects. Gene therapy is an emerging strategy that can improve targeting and reduce side effects, and nucleic-acid drugs such as siRNA have attracted major research interest. Nanocarriers, including liposomes, can deliver these agents to tumor sites, but gene therapy alone may not fully eradicate tumors and can lead to recurrence. This review synthesizes combination approaches using nanoplatform-mediated gene therapy with modalities such as phototherapy and magnetic hyperthermia to produce synergistic effects, and it highlights key bottlenecks and barriers to improve clinical efficacy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/combinational-gene-therapy-toward-cancer-with-nanoplatform-strategies-and-principles/385315/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/combinational-gene-therapy-toward-cancer-with-nanoplatform-strategies-and-principles/385315.png","ImageObject",300,407,{"name":92,"@type":93},"Aldword","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are traditional cancer therapies like chemotherapy and radiotherapy considered suboptimal?","Question",{"text":112,"@type":113},"They can have significant side effects and their clinical effects are not ideal, especially given high mortality and treatment limitations.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role do nanocarriers and nanoplatforms play in gene therapy?",{"text":117,"@type":113},"Nanocarriers such as liposomes protect nucleic-acid drugs, enable targeted delivery to tumors, and can support functions like escaping lysosomes and codelivering additional therapeutics.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is combining gene therapy with other therapies beneficial?",{"text":121,"@type":113},"Gene therapy alone may be insufficient to eradicate tumors and recurrence remains a risk; combining it with therapies such as phototherapy and magnetic hyperthermia can generate synergistic effects through different mechanisms.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},385315,1791156034,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},2336478940917,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","This article is licensed under CC-BY-NC-ND 4.0  \n[pubs.acs.org/materialsau](pubs.acs.org/materialsau)  Review   \nCombinational Gene Therapy toward Cancer with Nanoplatform: Strategies and Principles  \nJinhui Lin, Xinlian Wang, Dongqi Ni, Yandong Chen, Chunying Chen, and Ying Liu*  \n Cite This: ACS Mater. Au 2023, 3, 584−599  \nRead Online  \n\n|  |  |  |  |\n| --- | --- | --- | --- |\n| ACCESS   | Metrics & More |  |  Article Recommendations |\n\nABSTRACT: Cancer remains a significant threat to human health. While numerous therapies have been developed to combat the disease, traditional treatments such as chemotherapy and radiotherapy are suboptimal and associated with significant side effects. Gene therapy isan emerging therapeutic approach that offers improved targeting and reduced side effects compared with traditional treatments. Using siRNA and other nucleic acid-based drugs in cancer treatment has generated significant interest among researchers. Nanocarriers, such as liposomes, can effectively deliver these agents to tumor sites. However, gene therapy alone is often insufficient to eradicate tumors, and there is a risk of recurrence. Therefore, combining gene therapy with other therapies using nanocarriers, such as phototherapy and magnetic hyperthermia therapy, can lead to synergistic therapeutic effects through different mechanisms. In this review, we summarize various ways in which gene therapy can be combined with other therapies and highlight the role of nanoplatforms in mediating these combined therapies, which would inspire novel design ideas toward combination therapies. Additionally, bottlenecks and barriers to gene therapy should be addressed in the near future to achieve better clinical efficacy. KEYWORDS: combinational therapy, gene therapy, tumor treatment, nanoplatform, chemotherapy, phototherapy,  \nmagnetic hyperthermia therapy, immune therapy  \n1. INTRODUCTION  \nCancer, a major public health problem worldwide, has tended to be the leading cause of death in the 21st century. According to the American Cancer Society estimates, nearly 600,000 people in the United States will die because of cancer in 2022.1 The number of Americans with cancer history is estimated tobe more than 22.1 million in 2030 based on the growth and aging of the population alone.2 Chemotherapy, radiotherapy, and surgery are the main treatments for tumors, but their effects are not ideal for high mortality and side effects clinically. Meanwhile, tumor recurrence and metastasis are still a great challenge clinically, while there are no suitable therapeutics. After almost 30 years of development, gene therapy is becoming one of the most widely used therapeutic strategies except traditional therapies against cancers and can import healthy exogenous or therapeutic genes into host cells to kill cancer cells or protect normal cells.3 Several types of nucleic acid drugs were explored to heal cancer, such as Bcl-2 siRNA and suicide gene. Nucleic acid drugs can be divided into DNA and RNA, interfering with or regulating targeted gene expression in specific cells. Most types of DNA drugs target the cell nucleus, while RNA drugs target the cytoplasm. However, gene drugs can be easily degraded in vessels and into other organs; therefore, gene drugs are limited clinically.  \nThe nanodrug delivery system provides an excellent platform for the delivery of gene drugs with its protective properties and targeted effects. Through rational design, nanomaterials can encapsulate nucleic acids effectively and protect gene drugs from degradation. Moreover, some types of nanomaterials could help gene drugs escape from lysosome and codelivery other drugs with nucleic acid. Many nanovectors are developed to deliver gene drugs, including liposomes, cationic polymers, etc. Nowadays, novel therapies are urgently needed for cancer treatments. Combining gene therapy with the currently available therapies such as chemotherapy or radiation therapy provides surprising hope for ","cbCaisIQ33gBBS0E","https://ap.wps.com/l/cbCaisIQ33gBBS0E","pdf",2972538,16,"English","# Abstract\n# Introduction\n# Gene Therapy for Tumors\n## Advantages of Gene Therapy","[{\"question\":\"Why are traditional cancer therapies like chemotherapy and radiotherapy considered suboptimal?\",\"answer\":\"They can have significant side effects and their clinical effects are not ideal, especially given high mortality and treatment limitations.\"},{\"question\":\"What role do nanocarriers and nanoplatforms play in gene therapy?\",\"answer\":\"Nanocarriers such as liposomes protect nucleic-acid drugs, enable targeted delivery to tumors, and can support functions like escaping lysosomes and codelivering additional therapeutics.\"},{\"question\":\"Why is combining gene therapy with other therapies beneficial?\",\"answer\":\"Gene therapy alone may be insufficient to eradicate tumors and recurrence remains a risk; combining it with therapies such as phototherapy and magnetic hyperthermia can generate synergistic effects through different mechanisms.\"}]","Combinational Gene Therapy toward Cancer with Nanoplatform - Strategies and Principles | PDF",1790267958]