[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-416732-105":59,"doc-detail-416732-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","combination-of-hyaluronic-acid-and-polynucleotides-injection-for-the-treatment-of-cheilitis-simplex-case-report","Combination of Hyaluronic Acid and Polynucleotides Injection for the Treatment of Cheilitis Simplex - Case Report","","Cheilitis simplex is a common cheilitis presenting with cracked lips, fissures, and desquamation from multiple causes. A case report evaluated a lip booster injection containing 1% hyaluronic acid (HA) and 1% polynucleotides (PN), with 0.3% lidocaine for anesthesia. A 30-year-old woman with worsening dry, chapped lips and occasional bleeding underwent a single subdermal injection. Hydration increased after injection, peaking at two weeks, and remained above baseline through six weeks. Spectrophotometric results showed increased brightness and rosier pigmentation. The regimen was concluded to be effective, practical, and pain-free, with additional pigment-enhancing benefits, while recommending further studies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/combination-of-hyaluronic-acid-and-polynucleotides-injection-for-the-treatment-of-cheilitis-simplex-case-report/416732/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/combination-of-hyaluronic-acid-and-polynucleotides-injection-for-the-treatment-of-cheilitis-simplex-case-report/416732.png","ImageObject",300,407,{"name":92,"@type":93},"Alexandar","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What condition was treated in this case report and how was it identified?","Question",{"text":112,"@type":113},"The patient was diagnosed with cheilitis simplex, characterized by cracked lips, fissures, or desquamation, and the case described a presentation of dry and chapped lips that occasionally bled.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What was injected and what anesthetic was included?",{"text":117,"@type":113},"A single subdermal injection combined 1% hyaluronic acid (HA), 1% polynucleotides (PN), and 0.3% lidocaine as the anesthetic agent.",{"name":119,"@type":110,"acceptedAnswer":120},"How did the injection affect hydration and lip pigmentation over time?",{"text":121,"@type":113},"Lip hydration increased gradually, peaked two weeks after injection, and decreased gradually by six weeks while staying higher than baseline. Spectrophotometric analysis also indicated increased brightness and a shift in pigmentation toward a rosier hue.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},416732,1791476679,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},962090768658,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Clinical, Cosmetic and Investigational Dermatology  \n Open Access Full Text Article  \nC ASE REPORT  \nCombination of Hyaluronic Acid and Polynucleotides Injection for the Treatment of Cheilitis Simplex  \nKartika Ruchiatan , Yuri Yogya , Ilma Arifani , Reti Hindritiani , Diah Puspitosari , Trustia Rizqandaru , Srie Prihianti Gondokaryono , Pati Aji Achdiat   \nDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung, Indonesia  \nCorrespondence: Kartika Ruchiatan, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran – Dr. Hasan Sadikin General Hospital, Jl. Pasteur 38, Bandung, West Java, Indonesia, Tel +62811247932, Fax +62222032426, Email [kartika.ruchiatan@unpad.ac.id](kartika.ruchiatan@unpad.ac.id)  \n\n| Abstract: Cheilitis simplex is a prevalent form of cheilitis that is characterized by the presence of cracked lips, fissures, or desquamation, due to various etiologies. Utilization of “boosters” as a treatment for chapped lips has not been extensively researched. This case report aimed to describe the efficacy of lip booster injection comprising active ingredients of 1% hyaluronic acid (HA) and 1% polynucleotides (PN), with 0.3% lidocaine as anesthetic agent. A 30-year-old female patient presented with a chief complaint of dry and chapped lips that occasionally bleed. This condition had recently deteriorated, and the application of topical treatment had not yielded substantial improvement, which led to a state of distress for the patient. She was diagnosed with cheilitis simplex and was subsequently treated with a single subdermal injection of a combination of 1% HA, 1% PN, and 0.3% lidocaine. Lip hydration was increased gradually, as measured by tewameter, with peak rate of hydration (26 .218 g/m2/h) occurred two weeks after injection, and subsequently decreased gradually until six weeks after injection (29 .926 g/m2/h); however, the rate of hydration remained higher than the baseline value (34 .386 g/m2/h) . Additionally, the lips exhibited an increase in brightness and a shift in pigmentation toward a rosier hue, as substantiated by spectrophotometric analysis. The mechanism of HA and PN include providing hydration and stimulating dermal fibroblast activity. However, PN may also exert an additional effect of improving lip pigmentation by reducing melanin and increasing hemoglobin levels. In conclusion, the lip booster injection, comprising 1% PN, 1% non-cross-linked HA, and 0.3% lidocaine, is an efficacious and practical treatment option for cheilitis simplex. This treatment option offers the additional benefits of being pain-free and enhancing lip pigmentation. Further studies are required to confirm these findings.\u003Cbr>Keywords: cheilitis simplex, dry and chapped lips, hyaluronic acid, lip booster, polynucleotide |\n| --- |\n| Introduction\u003Cbr>The lips represent one of the most appealing characteristics of the human face, exerting a substantial influence on our perceptions of an individual’s health and aesthetics.1,2 They differ from the facial skin in several ways; notably, the lips have a weaker barrier function owing to the thin stratum corneum, which has only three to five layers, and incomplete keratinization in some areas.1,3,4 In addition, there is a very low number of free sebaceous glands and no sweat glands to provide moisture.3,4 These factors, in combination with constant exposure to environmental factors, render the lips more susceptible to dryness and peeling.3–5\u003Cbr>Chapped lips, also known as cheilitis simplex, common cheilitis, or cheilitis sicca, is an inflammatory condition of the lips which is characterized by the presence of cracked lips, fissures, or desquamation, typically manifesting in the lower lip region.6,7 It is one of the most prevalent subtypes of cheilitis, with a multifactorial etiology that includes, but is not limited to, irritation due to lip licking behavior, incessant biting of the","cbCaiq0G5ODCkFSn","https://ap.wps.com/l/cbCaiq0G5ODCkFSn","pdf",1131481,"English","# Introduction\n## Background on cheilitis simplex and cheilitis sicca\n## Rationale for lip boosters and the term \"lip booster\"","[{\"question\":\"What condition was treated in this case report and how was it identified?\",\"answer\":\"The patient was diagnosed with cheilitis simplex, characterized by cracked lips, fissures, or desquamation, and the case described a presentation of dry and chapped lips that occasionally bled.\"},{\"question\":\"What was injected and what anesthetic was included?\",\"answer\":\"A single subdermal injection combined 1% hyaluronic acid (HA), 1% polynucleotides (PN), and 0.3% lidocaine as the anesthetic agent.\"},{\"question\":\"How did the injection affect hydration and lip pigmentation over time?\",\"answer\":\"Lip hydration increased gradually, peaked two weeks after injection, and decreased gradually by six weeks while staying higher than baseline. Spectrophotometric analysis also indicated increased brightness and a shift in pigmentation toward a rosier hue.\"}]","Combination of Hyaluronic Acid and Polynucleotides Injection for the Treatment of Cheilitis Simplex - Case Report | PDF",1790606497]