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This systematic review identifies the effects of probiotics, prebiotics, symbiotics, and related natural changes on colorectal cancers from PubMed records spanning 2010–2021. Protective findings highlight short-chain fatty acids, especially acetate and butyrate, which reduce inflammation, limit colonocyte proliferation, and support malignant-cell apoptosis.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/colorectal-cancer-and-microbiota-systematic-review/340741/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/colorectal-cancer-and-microbiota-systematic-review/340741.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the goal of this systematic review?","Question",{"text":113,"@type":114},"To detect the effect of microbiota modulation using probiotics, prebiotics, symbiotics, and natural changes on colorectal cancers.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were studies selected for analysis?",{"text":118,"@type":114},"PubMed searches retrieved original in vivo English-language articles from 2010 to 2021 using keywords related to colorectal cancers, their treatments, and microbiota concepts (probiotics, prebiotics, symbiotics, dysbiosis, nutritional treatment). From 198 initial records, 61 studies were analyzed.",{"name":120,"@type":111,"acceptedAnswer":121},"What protective mechanisms are described for microbiota metabolites?",{"text":122,"@type":114},"Gut microbiota short-chain fatty acids (acetate and butyrate) show protective effects against colorectal cancers by reducing inflammatory cytokines, inhibiting colonocyte proliferation, and promoting malignant-cell apoptosis.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},340741,1790314704,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?_k=1776742907772140068","Review paper  \nColorectal cancer and microbiota: systematic review  \nNauryzbay Imanbayev1, Yerbolat Iztleuov2, Yerbol Bekmukhambetov3, Ibrahim A. Abdelazim4,  \nAinur Donayeva5, Ainur Amanzholkyzy5, Zhumasheva Aigul6, Imanbayeva Aigerim1, Yergaliyev Aslan7  \n1 Department of Oncology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan 2 Department of Radiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan 3Association of Individual Entrepreneurs and Legal Entities, National Chamber of Health, Astana, Kazakhstan 4 Department of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt 5 Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan  \n6 Department of Pathomorphology, Medical Centre of West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan 7 Department of General Surgery, Medical Centre of West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan  \nGastroenterology Rev 2024; 19 (4): 380–396 DOI: [https://doi.org/10.5114/pg.2024.136228](https://doi.org/10.5114/pg.2024.136228)  \nKey words: colorectal cancer, microbiota, review.  \nAddress for correspondence: Prof. Ibrahim A. Abdelazim MD, Department of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams  \nUniversity, Cairo, Egypt, phone: +965-66551300, e-mail: [dr.ibrahimanwar@gmail.com](dr.ibrahimanwar@gmail.com)  \nAbstract  \nIntroduction: The gut microbiome maintains the mucus membrane barrier’s integrity, and it is modulated by the host’s immune system.  \nAim: To detect the effect of microbiota modulation using probiotics, prebiotics, symbiotics, and natural changes on colorectal cancers (CRCs) .  \nMethods: A PubMed search was conducted to retrieve the original and in vivo articles published in English language from 2010 until 2021 containing the following keywords: 1) CRCs, 2) CRCs treatment (i.e. surgical, chemotherapy, radiotherapy and/ or immunotherapy), and 3) microbiota probiotic(s), prebiotic(s), symbiotic(s), dysbiosis and/or nutritional treatment. A total of 198 PubMed records/articles were initially identified. 108 articles were excluded at the initial screening, and another 29 articles were excluded after reviewing the abstracts, and finally 61 studies were analysed for this systematic review.  \nResults: The gut microbiota metabolites and (SCFAs) short-chain fatty acids (i.e. acetate and butyrate) have a protective effect against CRCs. SCFAs reduce the inflammatory cytokines, inhibit colonocyte proliferation, and promote malignant cell apoptosis. Butyrate maintains the integrity of the mucus membrane barrier and reduces intestinal mucosal inflammation. Reduced butyric acid level and increased inflammatory cytokines were observed after reduced Bacteroides fragilis and Bacteroides vulgatus species in the colon. Akkermansia muciniphila bacterium decreased in patients with CRCs.  \nConclusions: Prebiotics (i. e. inulin and resistant starch, SCFAs producers) and consumption of unprocessed plant products are useful for developing and maintaining healthy gut microbiota. The pro-, pre-and/or symbiotics may be useful when carefully selected for CRC patients, to restore beneficial gut microbiota and support treatment efficacy.  \nIntroduction  \nApproximately 10–20% of colorectal cancer (CRC) patients have a family history of the same disease [1], and 5–7% of CRCs have a clear genetic origin [2] . Hereditary CRC syndromes are divided into CRC with polyposis and CRC without polyposis (i. e. Lynch syndrome)  \n[3] . Risk factors for CRCs include inflammatory bowel disease (i.e. Chron’s and ulcerative colitis) [4] .  \nThe chronic inflammation (i.e. Chron’s and ulcerative colitis) is associated with release of inflammatory cytokines with subsequent chronic DNA and cell damage [3]. The chronic DNA/cell damage and/or genetic mutations predispose to the development of premalignant polyps  \nor lesions [5] . The premalignant polyp can be fu","cbCaii273zxEpDCw","https://ap.wps.com/l/cbCaii273zxEpDCw","pdf",167997,17,"English","# Abstract\n## Introduction\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the goal of this systematic review?\",\"answer\":\"To detect the effect of microbiota modulation using probiotics, prebiotics, symbiotics, and natural changes on colorectal cancers.\"},{\"question\":\"How were studies selected for analysis?\",\"answer\":\"PubMed searches retrieved original in vivo English-language articles from 2010 to 2021 using keywords related to colorectal cancers, their treatments, and microbiota concepts (probiotics, prebiotics, symbiotics, dysbiosis, nutritional treatment). From 198 initial records, 61 studies were analyzed.\"},{\"question\":\"What protective mechanisms are described for microbiota metabolites?\",\"answer\":\"Gut microbiota short-chain fatty acids (acetate and butyrate) show protective effects against colorectal cancers by reducing inflammatory cytokines, inhibiting colonocyte proliferation, and promoting malignant-cell apoptosis.\"}]","Colorectal cancer and microbiota - systematic review | PDF",1790038593,43]