[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-427428-105":59,"doc-detail-427428-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","cognitive-symptoms-across-the-menopause-transition-are-not-explained-by-acute-or-chronic-stress","COGNITIVE SYMPTOMS ACROSS THE MENOPAUSE TRANSITION ARE NOT EXPLAINED BY ACUTE OR CHRONIC STRESS","","Subjective cognitive difficulties are increasingly recognized as an early marker of Alzheimer’s disease. In women, cognitive complaints during the menopausal transition are often attributed to elevated stress, yet menopause-related physiological changes may also affect cognition. The study tested whether subjective cognitive complaints predict objective cognitive performance independently of acute or chronic stress in 112 women across menopause stages, using SCoPE, the Linus Health Core Cognitive Evaluation, and stress measures (acute and OCSQ).",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/cognitive-symptoms-across-the-menopause-transition-are-not-explained-by-acute-or-chronic-stress/427428/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/cognitive-symptoms-across-the-menopause-transition-are-not-explained-by-acute-or-chronic-stress/427428.png","ImageObject",300,407,{"name":92,"@type":93},"Theodore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main hypothesis about cognition during menopause?","Question",{"text":112,"@type":113},"The study hypothesized that subjective cognitive difficulties would predict objective cognition independently of acute or chronic stress.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were subjective and objective cognition measured?",{"text":117,"@type":113},"Subjective cognition was measured with a 6-item scale (SCoPE). Objective cognition was assessed with a digital evaluation (Digital Clock and Recall) within the Linus Health Core Cognitive Evaluation.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the results show regarding stress as an explanation?",{"text":121,"@type":113},"SCoPE negatively predicted objective cognition, and even after adjusting for stress, subjective complaints remained an independent predictor while stress measures were non-significant.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},427428,1790765844,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Innovation in Aging, 2025, Vol. 9, No. S2 699  \nAbstract citation ID: igaf122.2382  \nCOGNITIVE SYMPTOMS ACROSS THE MENOPAUSE  \nTRANSITION ARE NOT EXPLAINED BY ACUTE OR  \nCHRONIC STRESS  \nKavya Jhaveri1, Teresa Facchetti1, Sandra Rizer1, Jadira Cuevas1, Sarah Tom1, Jillian Joyce2, Mary Rosser1, and Stephanie Cosentino1, 1. Columbia University Irving Medical Center, New York, New York, United States, 2. University of Southern California, Los Angeles, California, United States  \nSubjective cognitive difficulties are increasingly recognized asan early marker of Alzheimer’s disease. Cognitive complaints in women are often attributed to elevated stress, particularly during the menopausal transition. However, physiological changes during menopause may impact cognition. Here, we hypothesized that subjective cognitive difficulties would predict objective cognition independently of acute or chronic stress—acknowledging that while stress significantly impacts cognition, it does not fully explain the relationship between subjective and objective cognition. 112 women aged 45 + (mean age = 61.9, SD = 10.1, range=45-85) at different stages of menopause participated in the study. Subjective cognition was measured with a 6-item scale (SCoPE). The Linus Health Core Cognitive Evaluation, a digital cognitive health assessment, measured objective cognition (Digital Clock and Recall) and acute stress (“In the last month, there has been a significant increase in stress in my life”) . Chronic stress was measured by the Ongoing Chronic Stressors Questionnaire (OCSQ) . Linear regression showed SCoPE negatively predicted DCR (B=-.596, p=.008). Women with subjective complaints (N=62) reported higher acute (Mann-Whitney U test:  \np = 0.043, U = 1251.0, Z=-2.024) and chronic stress (Mann-Whitney U test: p=.045, U =1210.5, Z=-.2003) than those without (N = 50) . In multiple regression adjusting for stress, SCoPE emerged as an independent predictor of DCR (B=-.564, p=.016) while stress was non-significant (OCSQ: B=-.031, p=.317; LHQ Q4: B=.043, p=.852) . These findings suggest that while stress is elevated with subjective cognitive complaints, it does not fully account for their objective cognitive deficits, highlighting the need for multifaceted approaches to assess and intervene during menopausal transition to reduce dementia risk.","cbCaivV29EEDwzWH","https://ap.wps.com/l/cbCaivV29EEDwzWH","pdf",48428,"English","# Overview\n## Study Hypothesis\n## Participants and Measures\n## Statistical Results\n## Conclusions","[{\"question\":\"What was the study’s main hypothesis about cognition during menopause?\",\"answer\":\"The study hypothesized that subjective cognitive difficulties would predict objective cognition independently of acute or chronic stress.\"},{\"question\":\"How were subjective and objective cognition measured?\",\"answer\":\"Subjective cognition was measured with a 6-item scale (SCoPE). Objective cognition was assessed with a digital evaluation (Digital Clock and Recall) within the Linus Health Core Cognitive Evaluation.\"},{\"question\":\"What did the results show regarding stress as an explanation?\",\"answer\":\"SCoPE negatively predicted objective cognition, and even after adjusting for stress, subjective complaints remained an independent predictor while stress measures were non-significant.\"}]","COGNITIVE SYMPTOMS ACROSS THE MENOPAUSE TRANSITION ARE NOT EXPLAINED BY ACUTE OR CHRONIC STRESS | PDF",1790643821]