[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-353388-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-353388-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","cog8-serves-as-a-predictive-and-prognostic-biomarker-in-lung-adenocarcinoma-and-other-human-malignancies","COG8 serves as a predictive and prognostic biomarker in lung adenocarcinoma and other human malignancies","","Objective: Investigate dysregulated COG8 expression, its clinical relevance, and underlying mechanisms in lung adenocarcinoma (LUAD) and other human malignancies. Methods: Integrated multi-cohort microarray and RNA-seq data from public repositories, assessed COG8 protein via immunohistochemistry, used SMD and Wilcoxon tests for differential expression, and applied ROC and Cox/Kaplan–Meier analyses for clinical relevance. Results: COG8 was elevated in LUAD, associated with survival, and showed subtype-specific links to mutation burden, instability, neoantigens, and immune infiltration. Conclusion: COG8 is a clinically significant predictive and prognostic biomarker.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/cog8-serves-as-a-predictive-and-prognostic-biomarker-in-lung-adenocarcinoma-and-other-human-malignancies/353388/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/cog8-serves-as-a-predictive-and-prognostic-biomarker-in-lung-adenocarcinoma-and-other-human-malignancies/353388.png","ImageObject",300,407,{"name":42,"@type":43},"mieayamfan","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-22",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main objective of the study on COG8?","Question",{"text":63,"@type":64},"To examine dysregulated COG8 expression, its clinical relevance, and the mechanisms underlying its role in LUAD and other human malignancies.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was COG8 expression evaluated in lung adenocarcinoma?",{"text":68,"@type":64},"COG8 mRNA was assessed using multi-cohort transcriptomic datasets, and COG8 protein levels in LUAD were evaluated using immunohistochemical staining.",{"name":70,"@type":61,"acceptedAnswer":71},"What clinical meaning does COG8 have according to the study results?",{"text":72,"@type":64},"Higher COG8 expression was associated with overall survival in LUAD and showed cancer-type-specific relationships with worse or improved prognosis across multiple cancers, supporting its predictive and prognostic value.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},353388,1790809955,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},962090893677,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Tan et al. Discover Oncology (2026) 17:1202 Discover Oncology  \n[https://doi.org/10.1007/s12672-026-05401-6](https://doi.org/10.1007/s12672-026-05401-6)  \nRESEARCH Open Access  \nCOG8 serves as a predictive and prognostic  biomarker in lung adenocarcinoma and other human malignancies  \nFei-Xiang Tan1†, Chun-Yan Zhao2†, Guo-Sheng Li3, Yu-Xing Tang2, Gang Chen2, Wan-Ying Huang2* and Zhi-Yi He 1*  \n†Fei-Xiang Tan and Chun-Yan Zhao are recognized as co-first authors, contributing equally to the research work.  \n*Correspondence:  \nWan-Ying Huang [huangwanying_gxmu@163.com](huangwanying_gxmu@163.com)[ ](huangwanying_gxmu@163.com)Zhi-Yi He  \n[Zhiyi-river@163.com](Zhiyi-river@163.com)  \n1Division of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China  \n2Department of Pathology, The First Affiliated Hospital of Guangxi Medical University,  \nNanning 530021, Guangxi, China 3Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China  \nAbstract  \nObjective The main objective of this study is to investigate the dysregulated expression, clinical relevance, and underlying mechanisms of COG8 in lung adenocarcinoma (LUAD) and other human malignancies.  \nMethods We assembled multi-cohort microarray and RNA sequencing data for tumor and non-tumor controls from global repositories including ArrayExpress, Gene Expression Omnibus, The Cancer Genome Atlas, and Genotype-Tissue Expression.  \nCOG8 protein expression in LUAD was evaluated using immunohistochemical staining. Differential expression was assessed using standardized mean difference (SMD) for pooled effects and Wilcoxon rank-sum tests for individual datasets. Clinical relevance of COG8 was examined using receiver operating characteristic analyses and Cox/Kaplan– Meier survival analyses. Correlation between COG8 expression and tumor mutation burden, microsatellite instability, neoantigen count, and TIMER scores was evaluated using Spearman’s rank correlation. Gene set enrichment analysis was conducted to explore the potential signaling pathways associated with COG8 across tumor types. Results COG8 mRNA was higher in LUAD compared to the control group  \n(SMD = 0 . 29, 95% CI: 0 .12–0.46, p \u003C 0. 05), consistent with COG8 protein levels by immunohistochemistry (p \u003C 0. 05) . Elevated mRNA expression was associated with longer overall survival in LUAD (p \u003C 0. 05) and showed moderate discrimination between LUAD and controls (AUC = 0 . 72) . COG8 mRNA was also overexpressed in  \n11 additional cancer types (p \u003C 0. 05) . Higher COG8 expression was linked to worse prognosis in seven cancers (HR > 1; p \u003C 0. 05) and to improved overall and/or diseasespecific survival in four cancers (HR \u003C 1; p \u003C 0. 05) . In certain cancers, COG8 expression correlated with tumor mutation burden, microsatellite instability, neoantigen count, and immune infiltration levels (p \u003C 0. 05) . COG8 may impact signaling pathways such as cytokine-cytokine receptor interaction.  \nConclusion COG8 exhibits aberrant expression in LUAD and eleven other human malignancies, holding clinical significance as a predictive and prognostic biomarker.  \n© The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the articl","cbCaiiC0EYp9oD9H","https://ap.wps.com/l/cbCaiiC0EYp9oD9H","pdf",5163817,23,"English","# Introduction\n## COG complex and rationale for COG8\n# Methods\n## Data sources and preprocessing\n## Expression and clinical analyses\n## Pathway and correlation analyses\n# Results\n## Differential expression and survival associations\n## Pan-cancer prognostic patterns\n## Links to genomic features and immune infiltration\n## Enriched signaling pathways\n# Conclusion","[{\"question\":\"What is the main objective of the study on COG8?\",\"answer\":\"To examine dysregulated COG8 expression, its clinical relevance, and the mechanisms underlying its role in LUAD and other human malignancies.\"},{\"question\":\"How was COG8 expression evaluated in lung adenocarcinoma?\",\"answer\":\"COG8 mRNA was assessed using multi-cohort transcriptomic datasets, and COG8 protein levels in LUAD were evaluated using immunohistochemical staining.\"},{\"question\":\"What clinical meaning does COG8 have according to the study results?\",\"answer\":\"Higher COG8 expression was associated with overall survival in LUAD and showed cancer-type-specific relationships with worse or improved prognosis across multiple cancers, supporting its predictive and prognostic value.\"}]","COG8 serves as a predictive and prognostic biomarker in lung adenocarcinoma and other human malignancies | PDF",1790105077,58]