[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-333512-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-333512-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","coexisting-atrial-fibrillation-and-cancer-time-trends-and-associations-with-mortality-in-a-nationwide-dutch-study","Coexisting atrial fibrillation and cancer - time trends and associations with mortality in a nationwide Dutch study","","Coexisting atrial fibrillation (AF) and cancer complicate care for both conditions, prompting a nationwide epidemiological study in the Netherlands. The study identified individuals with incident AF or cancer from 2015–2019 and matched controls without prior AF or cancer by demographic characteristics. Cancer/AF baseline prevalence, 1-year diagnosis risk, and temporal trends were assessed, while time-dependent Cox regression estimated associations with all-cause mortality.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/coexisting-atrial-fibrillation-and-cancer-time-trends-and-associations-with-mortality-in-a-nationwide-dutch-study/333512/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/coexisting-atrial-fibrillation-and-cancer-time-trends-and-associations-with-mortality-in-a-nationwide-dutch-study/333512.png","ImageObject",300,407,{"name":42,"@type":43},"Violet","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the aim of the nationwide Dutch study on AF and cancer?","Question",{"text":63,"@type":64},"To provide a comprehensive epidemiology of coexisting atrial fibrillation (AF) and cancer, including prevalence, incidence, time trends, and associations with all-cause mortality.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were individuals with AF and cancer identified and compared?",{"text":68,"@type":64},"Individuals with incident AF (n = 320,139) or cancer (n = 472,745) during 2015–2019 were identified using Dutch nationwide statistics, and matched control cohorts without prior AF or cancer were created by demographic characteristics.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the study find about the relationship between AF and cancer and mortality?",{"text":72,"@type":64},"AF and cancer were increasingly coexisting over time and were bidirectionally associated with survival; however, the strength of the association varied by cancer type, and coexisting AF and cancer showed negative associations with survival.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},333512,1790145708,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146,"preview_page_count":4},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","European Heart Journal (2024) 45, 2201–2213 [https://doi.org/10.1093/eurheartj/ehae222](https://doi.org/10.1093/eurheartj/ehae222)  \nCLINICAL RESEARCH  \nCardio-oncology  \nCoexisting atrial fibrillation and cancer: time trends and associations with mortality in a nationwide Dutch study  \nQingui Chen  1*, Nienke van Rein1,2, Tom van der Hulle  3, Julius C. Heemelaar4,5, Serge A. Trines  4, Henri H. Versteeg6, Frederikus A. Klok  6,  \nand Suzanne C. Cannegieter  1,6  \n1Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands; 2Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands; 3Department of Medical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands; 4Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands; 5Cardiovascular Imaging Research Center, Division of Cardiology, and Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA; and 6Department of Medicine, Section of Thrombosis and Hemostasis, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands  \nReceived 5 September 2023; revised 24 February 2024; accepted 26 March 2024; online publish-ahead-of-print 15 April 2024  \nSee the editorial comment for this article ‘Cancer begets atrial fibrillation … and vice versa?’, by D. Farmakis and G. Filippatos, [https://doi.org/10.1093/eurheartj/ehae301](https://doi.org/10.1093/eurheartj/ehae301).  \nAbstract  \nBackground and Aims  \nCoexisting atrial fibrillation (AF) and cancer challenge the management of both. The aim of the study is to comprehensively provide the epidemiology of coexisting AF and cancer.  \n\n| . . .\u003Cbr>Methods | .\u003Cbr>Using Dutch nationwide statistics, individuals with incident AF (n = 320 139) or cancer (n = 472 745) were identified during the period 2015–19. Dutch inhabitants without a history of AF (n = 320 135) or cancer (n = 472 741) were matched as control cohorts by demographic characteristics. Prevalence of cancer/AF at baseline, 1-year risk of cancer/AF diagnosis, and their time trends were determined. The association of cancer/AF diagnosis with all-cause mortality among those with AF/cancer was estimated by using time-dependent Cox regression. |\n| --- | --- |\n| . . .\u003Cbr>Results | .\u003Cbr>The rate of prevalence of cancer in the AF cohort was 12.6%(increasing from 11.9% to 13.2%) compared with 5.6% in the controls; 1-year cancer risk was 2.5%(stable over years) compared with 1.8% in the controls [adjusted hazard ratio (aHR) 1.52, 95% confidence interval (CI) 1.46–1.58], which was similar by cancer type. The rate of prevalence of AF in the cancer cohort was 7.5%(increasing from 6.9% to 8.2%) compared with 4.3% in the controls; 1-year AF risk was 2.8%(stable over years) compared with 1.2% in the controls (aHR 2.78, 95% CI 2.69–2.87), but cancers of the oesophagus, lung, stomach, myeloma, and lymphoma were associated with higher hazards of AF than other cancer types. Both cancer diagnosed after incident AF (aHR 7.77, 95% CI 7.45–8.11) and AF diagnosed after incident cancer (aHR 2.55, 95% CI 2.47–2.63) were associated with all-cause mortality, but the strength of the association varied by cancer type. |\n| .\u003Cbr>Conclusions | .\u003Cbr>Atrial fibrillation and cancer were associated bidirectionally and were increasingly coexisting, but AF risk varied by cancer type. Coexisting AF and cancer were negatively associated with survival. |\n\n.  \n.  \n* Corresponding author. Tel: +31 648921874, Email: [q.chen@lumc.nl](q.chen@lumc.nl); [qingui4ch@gmail.com](qingui4ch@gmail.com)  \n© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License ([https://creativecommons","cbCaifCrsv02aphy","https://ap.wps.com/l/cbCaifCrsv02aphy","pdf",1622954,13,"English","# Abstract\n## Background and Aims\n## Methods\n## Results\n## Conclusions\n# Structured Graphical Abstract\n## Key Question\n## Key Finding\n## Take Home Message\n# Keywords\n# Introduction","[{\"question\":\"What was the aim of the nationwide Dutch study on AF and cancer?\",\"answer\":\"To provide a comprehensive epidemiology of coexisting atrial fibrillation (AF) and cancer, including prevalence, incidence, time trends, and associations with all-cause mortality.\"},{\"question\":\"How were individuals with AF and cancer identified and compared?\",\"answer\":\"Individuals with incident AF (n = 320,139) or cancer (n = 472,745) during 2015–2019 were identified using Dutch nationwide statistics, and matched control cohorts without prior AF or cancer were created by demographic characteristics.\"},{\"question\":\"What did the study find about the relationship between AF and cancer and mortality?\",\"answer\":\"AF and cancer were increasingly coexisting over time and were bidirectionally associated with survival; however, the strength of the association varied by cancer type, and coexisting AF and cancer showed negative associations with survival.\"}]","Coexisting atrial fibrillation and cancer - time trends and associations with mortality in a nationwide Dutch study | PDF",1790002829,33]