[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-374928-105":59,"doc-detail-374928-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","co-targeting-ferroptosis-and-immune-evasion-through-small-molecules-in-breast-cancer","Co-targeting ferroptosis and immune evasion through small molecules in breast cancer","","Breast cancer remains the most common cancer among women, with incidence and mortality still alarmingly high despite progress in diagnosis and therapy. Ferroptosis, a regulated cell death distinct from apoptosis, necrosis, and pyroptosis, is proposed as an alternative anticancer strategy. The review emphasizes that a full understanding of ferroptosis in breast cancer is incomplete, including ferroptotic inducers such as small-molecule drugs and natural products and how ferroptosis interfaces with immunotherapy. It highlights signaling crosstalk linking ferroptosis to the immune microenvironment, proposing small-molecule targeting of regulators like STAT3, AR, EZH2, and PRMT5 to induce ferroptosis while blocking immune escape.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/co-targeting-ferroptosis-and-immune-evasion-through-small-molecules-in-breast-cancer/374928/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/co-targeting-ferroptosis-and-immune-evasion-through-small-molecules-in-breast-cancer/374928.png","ImageObject",300,407,{"name":92,"@type":93},"nayy☆","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",18,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is ferroptosis considered a promising approach for breast cancer therapy?","Question",{"text":113,"@type":114},"Ferroptosis is a regulated form of cell death distinct from apoptosis, necrosis, and pyroptosis. The review describes it as a novel and promising strategy, including ferroptotic induction for pharmacotherapy.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What kinds of agents are discussed as ferroptotic inducers in breast cancer?",{"text":118,"@type":114},"The document focuses on ferroptotic inducers including small-molecule drugs and natural products, and how they may be leveraged therapeutically.",{"name":120,"@type":111,"acceptedAnswer":121},"How does the review connect ferroptosis with immune evasion and immunotherapy?",{"text":122,"@type":114},"It highlights signaling crosstalk bridging ferroptosis with the immune microenvironment. It also proposes targeting potential regulators (e.g., STAT3, AR, EZH2, PRMT5) with small molecules to both induce ferroptosis and inhibit immune escape.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},374928,1790323047,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},962090893153,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Review Article  \nAddress for Correspondence:  \nFu Peng, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan University, Chengdu 610041,  \nSichuan Province, China.  \nEmail: [pengf@scu.edu.cn](pengf@scu.edu.cn).  \n[https://orcid.org/0000-0003-0289-4426](https://orcid.org/0000-0003-0289-4426)  \nZhaokai Zhou, Department of Urology, National Clinical Research Center for Metabolic Diseases,The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China.  \nEmail: [258202130@csu.edu.cn](258202130@csu.edu.cn).  \n[https://orcid.org/0000-0001-6628-3750](https://orcid.org/0000-0001-6628-3750)  \nCo-targeting ferroptosis and immune evasion through small molecules in breast cancer  \nJianbo Zhou1,2, Wangji Yang1, Hailin Tang3, Yutian Zou3, Zhaokai Zhou4,  \nCheng Peng2, Fu Peng1,5  \n1West China School of Pharmacy, West China School of Medicine, Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; 2State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China;  \n3State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong Province, China; 4Department of Urology, National Clinical Research Center for Metabolic Diseases,The Second Xiangya Hospital of Central South University, Changsha, Hunan Province, China; 5Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan University, Chengdu, Sichuan Province, China  \nABSTRACT  \nBreast cancer accounts for the highest proportion of cancer cases among women worldwide. Despite remarkable advances in cancer diagnosis and treatment, novel precision therapy strategies for various subtypes of breast cancer are urgently needed. Ferroptosis, which is different from programmed cell death, such as apoptosis, necrosis, and pyroptosis, is considered an alternative method for cancer therapy. A comprehensive understanding offerroptosis in breast cancer is lacking, including, but not limited to, ferroptotic inducers (small molecule drugs and natural products) and the interaction between ferroptosis and immunotherapy. Induction of ferroptosis is recognized as a novel and promising strategy for cancer pharmacotherapy, and a comprehensive understanding of the role of ferroptosisin breast cancer could help provide alternative treatment strategies for breast cancer. Furthermore, we highlight the signaling crosstalk bridging ferroptosis with the immune microenvironment and the feasibility of targeting their potential regulators (e.g. , STAT3, AR, EZH2, and PRMT5) using small molecules to simultaneously achieve the induction offerroptosis and inhibition of immune escape.  \nKey words: breast cancer, ferroptosis, small molecules, natural products, tumor microenvironment  \nINTRODUCTION  \nDespite of encouraging advancements in prevention and treatment of breast cancer in recent years, its incidence and mortality remain alarmingly high. Breast cancer is the most prevalent type of among newly diagnosed cases in women, accounting for 11.7% of all cancer diagnoses globally.[1,2] The latest epidemiological statistics of breast cancer imply that nearly one-third of newly diagnosed cancers in women is breast cancer, comprising 14% of cancerrelated deaths among them. [3] Recent data  \nindicate that the diagnosis and mortality rate for breast cancer is 30% and 22%, respectively in the United States in 2021.[4] Furthermore, a trend of younger patien","cbCaicZwoM9m1l8y","https://ap.wps.com/l/cbCaicZwoM9m1l8y","pdf",6213372,21,"English","# Abstract\n# Introduction","[{\"question\":\"Why is ferroptosis considered a promising approach for breast cancer therapy?\",\"answer\":\"Ferroptosis is a regulated form of cell death distinct from apoptosis, necrosis, and pyroptosis. The review describes it as a novel and promising strategy, including ferroptotic induction for pharmacotherapy.\"},{\"question\":\"What kinds of agents are discussed as ferroptotic inducers in breast cancer?\",\"answer\":\"The document focuses on ferroptotic inducers including small-molecule drugs and natural products, and how they may be leveraged therapeutically.\"},{\"question\":\"How does the review connect ferroptosis with immune evasion and immunotherapy?\",\"answer\":\"It highlights signaling crosstalk bridging ferroptosis with the immune microenvironment. It also proposes targeting potential regulators (e.g., STAT3, AR, EZH2, PRMT5) with small molecules to both induce ferroptosis and inhibit immune escape.\"}]","Co-targeting ferroptosis and immune evasion through small molecules in breast cancer | PDF",1790202784,53]