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The coexistence of hematologic malignancies with solid tumors is extremely uncommon, and CMML combined with lung malignancy is even rarer. This case report describes a patient with CMML harboring ASXL1 and EZH2 mutations together with non-small cell lung cancer (lung squamous cell carcinoma).",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/co-existing-squamous-cell-carcinoma-and-chronic-myelomonocytic-leukemia-with-asxl1-and-ezh2-gene-mutations-a-case-report/375566/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/co-existing-squamous-cell-carcinoma-and-chronic-myelomonocytic-leukemia-with-asxl1-and-ezh2-gene-mutations-a-case-report/375566.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What does the case report focus on?","Question",{"text":113,"@type":114},"It reports co-existing chronic myelomonocytic leukemia (CMML) and lung squamous cell carcinoma in a single patient, including the genetic findings of ASXL1 and EZH2 mutations.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What initial symptoms led to medical evaluation?",{"text":118,"@type":114},"A 63-year-old male had toothache with cough, sputum production, and bloody sputum for three months, along with continuous bleeding after a tooth extraction.",{"name":120,"@type":111,"acceptedAnswer":121},"How did the patient progress after treatment?",{"text":122,"@type":114},"After azacitidine, programmed cell death protein 1, and platinum-based chemotherapy, the patient developed severe myelosuppression and ultimately died from leukocyte stasis and dyspnea.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},375566,1790382433,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","| W | J | C | C | World Journal of\u003Cbr>Clinical Cases |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Cases 2023 May 26; 11(15): 3643-3650  \nDOI: 10.12998/wjcc.v11.i15.3643 ISSN 2307-8960 (online)  \nCASE REPORT  \nCo-existing squamous cell carcinoma and chronic myelomonocytic leukemia with ASXL1 and EZH2 gene mutations: A case report  \nLai-Jun Deng, Yang Dong, Mi-Mi Li, Chang-Gang Sun  \nSpecialty type: Hematology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): B  \nGrade C (Good): C  \nGrade D (Fair): D  \nGrade E (Poor): 0  \nP-Reviewer: Papadopoulos VP, Greece; Sultana N, Bangladesh  \nReceived: February 16, 2023  \nPeer-review started: February 16, 2023  \nFirst decision: March 28, 2023  \nRevised: April 7, 2023  \nAccepted: April 19, 2023  \nArticle in press: April 19, 2023  \nPublished online: May 26, 2023  \nLai-Jun Deng, Chang-Gang Sun, Department of Hematology, Weifang Hospital of Traditional Chinese Medicine, Weifang 261000, Shandong Province, China  \nYang Dong, Department of Clinical Pharmacy, Weifang Hospital of Traditional Chinese Medicine, Weifang 261000, Shandong Province, China  \nMi-Mi Li, Department of Pathology, Weifang Hospital of Traditional Chinese Medicine, Weifang 261000, Shandong Province, China  \nCorresponding author: Lai-Jun Deng, MS, Staff Physician, Department of Hematology, Weifang Hospital of Traditional Chinese Medicine, No. 1055 Weizhou Road, Kuiwen District, Weifang 261000, Shandong Province, [China.](China. denglaijun1982@163.com)[ denglaijun1982@163.com](China. denglaijun1982@163.com)  \nAbstract  \nBACKGROUND  \nChronic myelomonocytic leukemia (CMML), a rare clonal hematopoietic stem cell disorder characterized by myelodysplastic syndrome and myeloproliferative neoplasms, has a generally poor prognosis, and easily progresses to acute myeloid leukemia. The simultaneous incidence of hematologic malignancies and solid tumors is extremely low, and CMML coinciding with lung malignancies is even rarer. Here, we report a case of CMML, with ASXL1 and EZH2 gene mutations, combined with non-small cell lung cancer (lung squamous cell carcinoma) .  \nCASE SUMMARY  \nA 63-year-old male, suffering from toothache accompanied by coughing, sputum, and bloody sputum for three months, was given a blood test after experiencing continuous bleeding resulting from a tooth extraction at a local hospital. Based on morphological results, the patient was diagnosed with CMML and bronchoscopy was performed in situ to confirm the diagnosis of squamous cell carcinoma in the lower lobe of the lung. After receiving azacitidine, programmed cell death protein 1, and platinum-based chemotherapy drugs, the patient developed severe myelosuppression and eventually fatal leukocyte stasis and dyspnea.  \nCONCLUSION  \nDuring the treatment and observation of CMML and be vigilant of the growth of multiple primary malignant tumors.  \nKey Words: Squamous cell carcinoma; Chronic myelomonocytic leukemia; Myelo-  \n WJCC  [https://www.wjgnet.com](https://www.wjgnet.com) 3643 May 26, 2023  Volume 11  Issue 15   \nDeng LJ et al. Squamous cell carcinoma and CMML  \nproliferative neoplasms; Myelodysplastic; ASXL1 gene mutations; EZH2 gene mutations; Case report  \n©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: A 63-year-old male, with a long history of heavy smoking, was diagnosed with chronic myelomonocytic leukemia (CMML), with additional sex combs-like and enhancer of zeste homolog 2 gene mutations, as well as non-small cell lung cancer (squamous cell carcinoma) . However, no such mutations were found in the lung cancer tissue. In CMML patients, pulmonary manifestations are nonspecific, and the rare presence of malignant tumors in the lungs poses challenges in diagn","cbCaivwwvcTdoTmF","https://ap.wps.com/l/cbCaivwwvcTdoTmF","pdf",11234572,"English","# Abstract\n## Background\n## Case Summary\n## Conclusion\n# Core Tip\n# Introduction\n## Chief complaints\n## History of present illness","[{\"question\":\"What does the case report focus on?\",\"answer\":\"It reports co-existing chronic myelomonocytic leukemia (CMML) and lung squamous cell carcinoma in a single patient, including the genetic findings of ASXL1 and EZH2 mutations.\"},{\"question\":\"What initial symptoms led to medical evaluation?\",\"answer\":\"A 63-year-old male had toothache with cough, sputum production, and bloody sputum for three months, along with continuous bleeding after a tooth extraction.\"},{\"question\":\"How did the patient progress after treatment?\",\"answer\":\"After azacitidine, programmed cell death protein 1, and platinum-based chemotherapy, the patient developed severe myelosuppression and ultimately died from leukocyte stasis and dyspnea.\"}]","Co-existing squamous cell carcinoma and chronic myelomonocytic leukemia with ASXL1 and EZH2 gene mutations - A case report | PDF",1790215384,23]