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This retrospective study analyzed DPC patients with lung cancer and built a survival nomogram for individualized overall survival (OS) prediction. Methods: 103 patients from Shengjing Hospital (2016–2021) were classified into synchronous and metachronous DPCs by a 6-month interval, with additional subgrouping for metachronous cases. Results: The study identified key risk factors for progression-free survival and OS and provided median OS and 3-/5-year rates. Conclusion: DPCs involving lung cancer accounted for 1.11% and the nomogram accurately predicts 3- and 5-year OS.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/clinicopathological-features-prognostic-factor-analysis-and-survival-nomogram-of-patients-with-double-primary-cancers-involving-lung-cancer/333388/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/clinicopathological-features-prognostic-factor-analysis-and-survival-nomogram-of-patients-with-double-primary-cancers-involving-lung-cancer/333388.png","ImageObject",300,407,{"name":92,"@type":93},"Aurora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-11","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How were patients with double primary cancers involving lung cancer categorized in the study?","Question",{"text":112,"@type":113},"Patients were grouped as synchronous DPCs or metachronous DPCs based on a 6-month cancer occurrence interval. Metachronous cases were further subdivided depending on whether lung cancer occurred first or the other cancer occurred first.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What risk factors were associated with progression-free survival and overall survival?",{"text":117,"@type":113},"Progression-free survival risk factors included Stage IV lung cancer and failure to undergo radical lung cancer surgery. Overall survival risk factors included squamous carcinoma, Stage IV lung cancer, and treatment-related factors such as failure to undergo radical surgery, chemotherapy, and specific therapy combinations.",{"name":119,"@type":110,"acceptedAnswer":120},"What survival outcomes and prediction tool did the study provide?",{"text":121,"@type":113},"The median OS was 37 months, with 3-year and 5-year OS rates of 50.9% and 35.9%. 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[Email:](Email: yulimail369@163.com)[ yulimail369@163.com](Email: yulimail369@163.com)  \nAbstract  \nBackground: Although the incidence of double primary cancers (DPCs) involving lung cancer is rising, they have not been studied sufficiently. This study retrospectively analyzed the clinicopathological and prognostic characteristics of DPC patients with lung cancer and developed a survival nomogram to predict the individual OS rates.  \nMethods: We included 103 DPC patients with lung cancer from Shengjing Hospital between 2016 and 2021. Based on the 6-month cancer occurrence interval, the cases were categorized as synchronous DPCs (sDPCs) or metachronous DPCs (mDPCs). Furthermore, the mDPCs were subdivided based on whether the lung cancer occurred first (LCF cohort) or the other cancer occurred first (OCF cohort).  \nResults: Among the patients, 35 (33.98%) and 68 (66.02%) had sDPCsand mDPCs, respectively. In the mDPCs cohort, 18 (26.47%) belonged to the LCF cohort and 50 (73.53%) to the OCF cohort. The most frequent primary cancer sites were the breast (27.18%), colorectum (22.33%), and urinary system (18.45%) . Independent risk factors for progression-free survival were Stage IV lung cancer (p = 0.008) and failure to undergo radical lung cancer surgery (p = 0.028) . The risk factors for OS included squamous carcinoma (p = 0.048), Stage IV lung cancer (p = 0.001), single cancer resection plus drug therapy (p \u003C0.001), drug therapy alone (p = 0.002), failure to undergo radical lung cancer surgery (p = 0.014), and chemotherapy (p = 0.042). The median OS was 37 months, with 3-and 5-year rates of 50.9% and 35.9%, respectively.  \nConclusion: DPCs involving lung cancer account for 1.11% of cases. The breast, colorectum, and urinary system were the most common extra-pulmonary sites, and mDPCs were more frequent than sDPCs. Radical lung cancer surgery significantly affects prognosis, and drug therapy alone maybe preferable when only one tumor is operable. The developed nomogram can accurately predict individual 3-year and 5-year OS rates.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.  \nCancer Medicine. 2024;13:e7296 .  \n[https://doi.org/10.1002/cam4.7296](https://doi.org/10.1002/cam4.7296)  \n[wileyonlinelibrary.com/journal/cam4](wileyonlinelibrary.com/journal/cam4)  \n1 of 17  \nKEYWORDS  \nClinicopathological features, double primary cancers, lung cancer, prognostic factor analysis, survival nomogram  \n1 | INTRODUCTION  \nLung cancer is one of the most prevalent cancers worldwide. According to the annual data compiled by the American Cancer Society on cancer incidence and mortality, the mortality rate for lung cancer has shown an accelerated decline in recent years. At the same time, survival rates for non-small cell lung cancer are rapidly improving.1  \nAs lung cancer survival rates improve, the late effects of the cancer become critical. The development of a new tumor is one of the serious late-onset effects. According to the National Cancer Institute Surveillance, Epidemiology, and End Results database, the subsequent risk of developing multiple primary cancers (MPCs) is 1%–16% . The proportion of patients ","cbCainDzgtdn5rrs","https://ap.wps.com/l/cbCainDzgtdn5rrs","pdf",3141649,17,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"How were patients with double primary cancers involving lung cancer categorized in the study?\",\"answer\":\"Patients were grouped as synchronous DPCs or metachronous DPCs based on a 6-month cancer occurrence interval. Metachronous cases were further subdivided depending on whether lung cancer occurred first or the other cancer occurred first.\"},{\"question\":\"What risk factors were associated with progression-free survival and overall survival?\",\"answer\":\"Progression-free survival risk factors included Stage IV lung cancer and failure to undergo radical lung cancer surgery. Overall survival risk factors included squamous carcinoma, Stage IV lung cancer, and treatment-related factors such as failure to undergo radical surgery, chemotherapy, and specific therapy combinations.\"},{\"question\":\"What survival outcomes and prediction tool did the study provide?\",\"answer\":\"The median OS was 37 months, with 3-year and 5-year OS rates of 50.9% and 35.9%. The developed nomogram was designed to accurately predict individual 3-year and 5-year OS rates for patients.\"}]","Clinicopathological features, prognostic factor analysis, and survival nomogram of patients with double primary cancers involving lung cancer | PDF",1790002214,43]