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Tissue temperatures were invasively measured at 1-minute intervals at depths of 1–20 mm. Results showed region-dependent heating during warm-up, ESHO minima exceeded, and temperatures insufficient for direct thermal cell killing. Thermography-controlled wIRA hyperthermia met ESHO criteria as a radiosensitizer while avoiding thermal skin toxicity risk.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/clinical-wira-hyperthermia-heating-properties-and-effectiveness-in-lower-trunk-regions-accordance-with-esho-quality-criteria-for-superficial-hyperthermia/506422/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/clinical-wira-hyperthermia-heating-properties-and-effectiveness-in-lower-trunk-regions-accordance-with-esho-quality-criteria-for-superficial-hyperthermia/506422.png","ImageObject",300,407,{"name":92,"@type":93},"Aldword","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-10-05",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does the study evaluate about wIRA-hyperthermia?","Question",{"text":112,"@type":113},"It evaluates heating characteristics of water-filtered infrared-A (wIRA) in vivo, including region-specific effectiveness in abdominal wall and lumbar tissue and conformity with ESHO quality criteria for superficial hyperthermia.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the wIRA treatment delivered and monitored?",{"text":117,"@type":113},"wIRA was applied to the abdominal wall and lumbar region for 60 minutes, with skin surface temperature limited to about 43°C. Tissue temperatures were invasively measured at 1-minute intervals across depths of 1–20 mm using fiber-optical probes, and skin thermography was used for control.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings regarding ESHO criteria and cell-killing risk?",{"text":121,"@type":113},"The study found that ESHO minimum requirements were exceeded in both regions for key metrics during heating-up, while measured tissue temperature levels were inadequate for direct thermal cell killing. The therapy also avoided the risk of thermal skin toxicity as a radiosensitizer.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},506422,1791309538,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336478940917,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","International Journal of Hyperthermia  \nISSN: (Print) (Online) Journal homepage: [https://www.tandfonline.com/loi/ihyt20](https://www.tandfonline.com/loi/ihyt20)  \nClinical wIRA-hyperthermia: heating properties and effectiveness in lower trunk regions and its accordance with ESHO quality criteria for superficial hyperthermia  \nHelmut Piazena, Peter Vaupel & Andreas R. Thomsen  \nTo cite this article: Helmut Piazena, Peter Vaupel & Andreas R. Thomsen (2023) Clinical wIRAhyperthermia: heating properties and effectiveness in lower trunk regions and its accordance with ESHO quality criteria for superficial hyperthermia, International Journal of Hyperthermia, 40:1, 2244208, DOI: 10. 1080/02656736 .2023.2244208  \nTo link to this article: [https://doi.org/10.1080/02656736.2023.2244208](https://doi.org/10.1080/02656736.2023.2244208)  \n© 2023 The Author(s) . Published with license by Taylor & Francis Group, LLC  \n\n|  View supplementary material  |\n| --- |\n|  Published online: 17 Aug 2023. |\n|  Submit your article to this journal  |\n|  Article views: 452 |\n|  View related articles  |\n|  View Crossmark data |\n\nFull Terms & Conditions of access and use can be found at [https://www.tandfonline.com/action/journalInformation?journalCode=ihyt20](https://www.tandfonline.com/action/journalInformation?journalCode=ihyt20)  \nINTERNATIONAL JOURNAL OF HYPERTHERMIA 2023, VOL. 40, NO. 1, 2244208  \n[https://doi.org/10.1080/02656736.2023.2244208](https://doi.org/10.1080/02656736.2023.2244208)  \nClinical wIRA-hyperthermia: heating properties and effectiveness in lower trunk regions and its accordance with ESHO quality criteria for superficial hyperthermia  \nHelmut Piazenaa , Peter Vaupelb,c  and Andreas R. Thomsenb,c   \naInterdisciplinary Center of Sleep Medicine, Charit – University Medicine Berlin, Berlin, Germany; bDepartment of Radiation Oncology, University Medical Center, University of Freiburg, Freiburg/Brsg, Germany; cGerman Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany  \nABSTRACT  \nPurpose: The heating characteristics of water-filtered infrared-A (wIRA) radiation were investigated in vivo in two body regions of healthy humans according to the quality standards of the European Society for Hyperthermic Oncology (ESHO) using an irradiance (infrared-A) of 146Wm􀀁2 as recommended for clinical superficial hyperthermia (HT) .  \nMethods: wIRA was applied to the abdominal wall and lumbar region for 60min. Skin surface temperature was limited to 􀀃43􀀄 C. Tissue temperatures were measured invasively at 1-min intervals before, during and after wIRA exposure using five fiber-optical probes at depths of 1–20mm.  \nResults: Significant differences between body regions occurred during the heating-up phase at depths of 5–15mm. Thermal steady states were reached at depths 􀀃5mm after exposures of 5–6min, and 􀀃20mm after 20min. On average, the minimum requirements of ESHO were exceeded in both regions by the following factors: 􀀅3 for the heating rate, 􀀅2 for the specific absorption rate and 􀀅1.4 for the temperature rise. Tissue depths with T90 􀀆 40􀀄 C and T50 > 41 􀀄 C were 􀀃10mm, and 􀀃20mm for Tmax 􀀃 43􀀄 C. The temperature decay time after termination of irradiation was 1–5min. Corresponding temperatures were 􀀃42.2 􀀄 C for CEM43 and 􀀃41.8 􀀄 C for CEM43T90, i.e., they are inadequate for direct thermal cell killing.  \nConclusions: Thermography-controlled wIRA-HT complies with the ESHO criteria for superficial HT as a radiosensitizer and avoids the risk of thermal skin toxicity.  \nARTICLE HISTORY  \nReceived 29 March 2023 Revised 19 June 2023 Accepted 29 July 2023  \nKEYWORDS  \nWater-filtered infrared-A (wIRA) irradiation; superficial hyperthermia; mild hyperthermia; tissue thermometry; skin thermography; ESHO guidelines  \n1. Introduction  \nLocalized mild hyperthermia using water-filtered infrared-A (wIRA-HT) radiation has been shown to be a potent radiosensitizer for superficial cancers and an effective treatment ","cbCaimHALXxaief7","https://ap.wps.com/l/cbCaimHALXxaief7","pdf",4240239,14,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusions\n# Introduction\n## Background and prior work\n## Study aims and design","[{\"question\":\"What does the study evaluate about wIRA-hyperthermia?\",\"answer\":\"It evaluates heating characteristics of water-filtered infrared-A (wIRA) in vivo, including region-specific effectiveness in abdominal wall and lumbar tissue and conformity with ESHO quality criteria for superficial hyperthermia.\"},{\"question\":\"How was the wIRA treatment delivered and monitored?\",\"answer\":\"wIRA was applied to the abdominal wall and lumbar region for 60 minutes, with skin surface temperature limited to about 43°C. Tissue temperatures were invasively measured at 1-minute intervals across depths of 1–20 mm using fiber-optical probes, and skin thermography was used for control.\"},{\"question\":\"What were the main findings regarding ESHO criteria and cell-killing risk?\",\"answer\":\"The study found that ESHO minimum requirements were exceeded in both regions for key metrics during heating-up, while measured tissue temperature levels were inadequate for direct thermal cell killing. The therapy also avoided the risk of thermal skin toxicity as a radiosensitizer.\"}]","Clinical wIRA-hyperthermia - heating properties and effectiveness in lower trunk regions - accordance with ESHO quality criteria for superficial hyperthermia | PDF",1791165168,35]