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This study evaluates soluble fms-like tyrosine kinase 1 (sFlt-1), an inflammation-associated marker, by measuring Flt-1 expression in peripheral CD14+ monocytes and plasma sFlt-1 using flow cytometry and ELISA across adult patients enrolled retrospectively.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/clinical-value-of-soluble-fms-like-tyrosine-kinase-1-sflt-1-in-adult-secondary-hemophagocytic-lymphohistiocytosis/436732/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/clinical-value-of-soluble-fms-like-tyrosine-kinase-1-sflt-1-in-adult-secondary-hemophagocytic-lymphohistiocytosis/436732.png","ImageObject",300,407,{"name":92,"@type":93},"Angel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-01","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the clinical focus of measuring sFlt-1 in adult sHLH?","Question",{"text":112,"@type":113},"The study focuses on whether sFlt-1 reflects disease inflammatory activity and can serve as a prognostic indicator for adult secondary hemophagocytic lymphohistiocytosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were Flt-1 and sFlt-1 levels measured in the study?",{"text":117,"@type":113},"Flt-1 expression on peripheral blood CD14+ monocytes was detected by flow cytometry, and plasma sFlt-1 levels were measured by ELISA.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the results show about sFlt-1 levels and outcomes?",{"text":121,"@type":113},"Plasma sFlt-1 was significantly higher in adult sHLH than in normal controls and a sepsis group. A threshold of sFlt-1 > 681.5 pg/mL was associated with unfavorable overall survival and remained an independent risk factor after adjustment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436732,1790815673,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},687207412472,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","J Chin MedAssoc  \nOriginal article  \nClinical value of soluble fms-like tyrosine kinase 1 (sFlt-1) in adult secondary hemophagocytic lymphohistiocytosis  \nWanying Chenga,b, Lingling Wanga,d, Xin Gaoa, Guangli Yina, Jujuan Wanga, Yongqian Shuc, Hongxia Qiua,b,* , Limin Duana,b,*  \naDepartment of Geriatric Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China; bDepartment of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China; cDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China; dDepartment of Hematology, Wuxi People’s Hospital, Wuxi, China  \nAbstract  \nBackground: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a syndrome characterized by an excessive systemic inflammatory response, manifested by multiple organ dysfunction, lacking reliable immune biomarkers for predicting their inflammatory status and prognosis. Soluble fms-like tyrosine kinase 1 (sFlt-1) is associated with various inflammation-related diseases, including sepsis and severe organ failure.  \nMethods: This study retrospectively included 32 adult sHLH patients diagnosed from January 2020 to December 2021. The expression of Flt-1 in peripheral blood CD14+ monocytes was detected by flow cytometry, and the level of plasma sFlt-1 was detected by ELISA.  \nResults: In our study, the results of flow cytometry reveal that the Flt-1 expression on CD14+ monocytes of peripheral blood from sHLH patients was higher than that in normal control. In plasma samples of sHLH patients, sFlt-1 levels were 677.8 (463 .2–929.7) pg/mL, significantly higher than in normal controls 377.18 (350 .4–424.6) pg/mL and sepsis group 378.3 (257 .0–499. 1) pg/mL. Besides, a positive correlation was found between sFlt-1 and IL-6 in sHLH patients. The analysis of univariate Cox regression indicated that sFlt-1 >681 .5 pg/mL demonstrated unfavorable overall survival (p = 0 .022) . Multivariate analysis demonstrated that sFlt-1 >681 .5 pg/mL was an independent factor associated with OS (p = 0 .041) after adjustment for confounders. Restricted cubic spline confirmed a linear and positive association between sFlt-1 and mortality risk.  \nConclusion: Retrospective analysis showed that sFlt-1 was a promising prognostic factor.  \nKeywords: Fms-like tyrosine kinase 1; Prognosis; Secondary hemophagocytic lymphohistiocytosis  \n1. INTRODUCTION  \nAdult secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare but potentially fatal disorder characterized by an excessive activation and proliferation of macrophages and T lymphocytes. These activated immune cells produce many proinflammatory cytokines, known as a “cytokine storm.”1 Various clinical signs and symptoms associated with abnormal cytokines are fever, hepatomegaly, splenomegaly, hemorrhagic manifestations, and  \n* Address correspondence. Dr. Hongxia Qiu, Department of Geriatric Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, [China. E-mail address: qhx9805@126.com](China. E-mail address: qhx9805@126.com) (H. Qiu); Dr. Limin Duan, Department of Geriatric Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China. E-mail address: [duanliminde@163.com](duanliminde@163.com) (L. Duan).  \nAuthor contributions: Dr. Wanying Cheng and Dr. Lingling Wang contributed equally to this work.  \nConflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2023) 86: 659-664.  \nReceived December 28, 2022; accepted March 23, 2023.  \ndoi: 10. 1097/JCMA.0000000000000943.  \nCopyright © 2023, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/by-","cbCaidKJ51eo8eVf","https://ap.wps.com/l/cbCaidKJ51eo8eVf","pdf",920720,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Methods\n## Patients","[{\"question\":\"What is the clinical focus of measuring sFlt-1 in adult sHLH?\",\"answer\":\"The study focuses on whether sFlt-1 reflects disease inflammatory activity and can serve as a prognostic indicator for adult secondary hemophagocytic lymphohistiocytosis.\"},{\"question\":\"How were Flt-1 and sFlt-1 levels measured in the study?\",\"answer\":\"Flt-1 expression on peripheral blood CD14+ monocytes was detected by flow cytometry, and plasma sFlt-1 levels were measured by ELISA.\"},{\"question\":\"What did the results show about sFlt-1 levels and outcomes?\",\"answer\":\"Plasma sFlt-1 was significantly higher in adult sHLH than in normal controls and a sepsis group. A threshold of sFlt-1 \\u003e 681.5 pg/mL was associated with unfavorable overall survival and remained an independent risk factor after adjustment.\"}]","Clinical value of soluble fms-like tyrosine kinase 1 (sFlt-1) in adult secondary hemophagocytic lymphohistiocytosis | PDF",1790678860,15]