[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-383493-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-383493-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","clinical-value-of-minimum-apparent-diffusion-coefficient-for-prediction-of-clinically-significant-prostate-cancer-in-the-transition-zone","Clinical value of minimum apparent diffusion coefficient for prediction of clinically significant prostate cancer in the transition zone","","Background: This study evaluates whether minimum apparent diffusion coefficient (ADC) values in PI-RADS 4/5 lesions relate to clinically significant prostate cancer in the transition zone. Methods: Data from 102 men undergoing transperineal cognitive fusion targeted biopsy for PI-RADS 4/5 transition-zone lesions (2016–2020) were analyzed. Results: Clinically significant cases showed lower minimum ADC than benign/insignificant cases, and multivariate analysis identified minimum ADC as an independent predictor; a cutoff of \u003C595 µm2/s increased detection. Conclusion: Minimum ADC adds value for identifying clinically significant cancer and may guide decisions on repeat biopsies after an initial negative targeted biopsy.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/clinical-value-of-minimum-apparent-diffusion-coefficient-for-prediction-of-clinically-significant-prostate-cancer-in-the-transition-zone/383493/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/clinical-value-of-minimum-apparent-diffusion-coefficient-for-prediction-of-clinically-significant-prostate-cancer-in-the-transition-zone/383493.png","ImageObject",300,407,{"name":42,"@type":43},"Liam","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the main aim of this study?","Question",{"text":63,"@type":64},"To determine whether ADC values in PI-RADS 4/5 lesions are associated with clinically significant prostate cancer in the transition zone, and to consider implications for follow-up after an initial negative targeted biopsy.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How many patients were included and how were they selected?",{"text":68,"@type":64},"A total of 102 patients were included after reviewing 146 records with PI-RADS 4/5 lesions; exclusions were applied for lesions confined to the peripheral zone or insufficient medical records.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the results show about minimum ADC as a predictor?",{"text":72,"@type":64},"Minimum ADC was independently associated with clinically significant prostate cancer, and using a cutoff value below 595 µm2/s increased the detection rate within the cohort.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},383493,1790624266,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":111,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":118},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","International Journal of Clinical Oncology (2023) 28:716–723  \n[https://doi.org/10.1007/s10147-023-02324-y](https://doi.org/10.1007/s10147-023-02324-y)  \nClinical value of minimum apparent diffusion coefficient for prediction of clinically significant prostate cancer in the transition zone  \nAshita Ono1 · Takeshi Hashimoto1 · Toshihide Shishido1 · Yosuke Hirasawa1 · Naoya Satake1 · Kazunori Namiki1 · Kazuhiro Saito2 · Yoshio Ohno1  \nReceived: 25 August 2022 / Accepted: 1 March 2023 / Published online: 24 March 2023 © The Author(s) 2023  \nAbstract  \nBackground This study investigated the association between apparent diffusion coefficients in Prostate Imaging Reporting and Data System 4/5 lesions and clinically significant prostate cancer in the transition zone.  \nMethods We included 102 patients who underwent transperineal cognitive fusion targeted biopsy for Prostate Imaging Reporting and Data System 4/5 lesions in the transition zone between 2016 and 2020. The association between apparent diffusion coefficients and prostate cancers in the transition zone was analyzed.  \nResults The detection rate of prostate cancer was 49%(50/102), including clinically significant prostate cancer in 37.3%(38/102) of patients. The minimum apparent diffusion coefficients in patients with clinically significant prostate cancer were 494.5 ± 133.6 µm2/s, which was significantly lower than 653.8 ± 172.5 µm2/s in patients with benign histology or clinically insignificant prostate cancer. Age, prostate volume, transition zone volume, and mean and minimum apparent diffusion coefficients were associated with clinically significant prostate cancer. Multivariate analysis demonstrated that only the minimum apparent diffusion coefficient value (odds ratio: 0.994; p \u003C 0.001) was an independent predictor of clinically significant prostate cancer. When the cutoff value of the minimum apparent diffusion coefficient was less than 595 µm2/s, indicating the presence of prostate cancer in the transition zone, the detection rate increased to 59.2%(29/49) in this cohort. Conclusion The minimum apparent diffusion coefficient provided additional value to indicate the presence of clinically significant prostate cancer in the transition zone. It may help consider the need for subsequent biopsies in patients with Prostate Imaging Reporting and Data System 4/5 lesions and an initial negative targeted biopsy.  \nKeywords Prostate cancer · Apparent diffusion coefficient · Transition zone  \nIntroduction  \nProstate cancer (PC) is the fourth most common cancer globally, and 1.41 million new cases were diagnosed in 2020 [1] . The National Comprehensive Cancer Network guidelines for early detection of PC recommend multiparametric magnetic resonance imaging (MRI) before biopsy [2] . Moreover, the introduction of the Prostate Imaging Reporting and Data  \n* Yoshio Ohno [yoshio-o@tokyo-med.ac.jp](yoshio-o@tokyo-med.ac.jp)  \nAshita Ono  \n[Ashi17@tokyo-med.ac.jp](Ashi17@tokyo-med.ac.jp)  \n1 Department of Urology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 1600023, Japan  \n2 Department of Radiology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 1600023, Japan  \nSystem (PI-RADS) has improved the detection of clinically significant PC (csPC) [3] . However, the detection rate of csPC has been reported to be as low as 21.3–70.5% in PI-RADS 4 lesions and 35.6–95.0% in PI-RADS 5 lesions [4–8]. Therefore, we often encounter patients with PI-RADS 4/5 lesions and an initial negative targeted biopsy. There is a need to understand how to manage such patients. In some cases, follow-up with a repeat MRI may be a possible option, while others may need an immediate repeat biopsy.  \nSeveral reports have demonstrated that the apparent diffusion coefficient (ADC) values can be used to detect several types of cancer [8, 9]. Regarding PC, there have been reports that ADC values of cancer tissue were significantly lower than those of normal peripheral zone (PZ) tis","cbCaipUIlg3s9gPT","https://ap.wps.com/l/cbCaipUIlg3s9gPT","pdf",841248,"English","# Abstract\n# Introduction\n# Patients and methods","[{\"question\":\"What was the main aim of this study?\",\"answer\":\"To determine whether ADC values in PI-RADS 4/5 lesions are associated with clinically significant prostate cancer in the transition zone, and to consider implications for follow-up after an initial negative targeted biopsy.\"},{\"question\":\"How many patients were included and how were they selected?\",\"answer\":\"A total of 102 patients were included after reviewing 146 records with PI-RADS 4/5 lesions; exclusions were applied for lesions confined to the peripheral zone or insufficient medical records.\"},{\"question\":\"What did the results show about minimum ADC as a predictor?\",\"answer\":\"Minimum ADC was independently associated with clinically significant prostate cancer, and using a cutoff value below 595 µm2/s increased the detection rate within the cohort.\"}]","Clinical value of minimum apparent diffusion coefficient for prediction of clinically significant prostate cancer in the transition zone | PDF",1790257292]