[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-329443-105":3,"doc-detail-329443-en":81,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","clinical-validation-on-role-of-cancer-diagnostic-probe-in-detecting-the-involved-cavity-margins-missed-in-permanent-pathology-of-tumor-side-in-breast-cancer-surgery","Clinical validation on role of cancer diagnostic probe in detecting the involved cavity margins missed in permanent pathology of tumor side in breast cancer surgery","","Cancer diagnostic probe (CDP) is evaluated as a real-time tool for breast cavity margin assessment, targeting improvements beyond conventional intra-operative margin shaving approaches. The system increased involved margin detection to 30% compared with frozen section. This study highlights CDP’s independent ability to identify involved cavity side margins not reported by permanent pathology at the tumor side interface. Among 147 CDP-detected margins, 23 lesions were missed as involved in permanent pathology, and histology served as the gold standard.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/clinical-validation-on-role-of-cancer-diagnostic-probe-in-detecting-the-involved-cavity-margins-missed-in-permanent-pathology-of-tumor-side-in-breast-cancer-surgery/329443/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/clinical-validation-on-role-of-cancer-diagnostic-probe-in-detecting-the-involved-cavity-margins-missed-in-permanent-pathology-of-tumor-side-in-breast-cancer-surgery/329443.png","ImageObject",300,407,{"name":42,"@type":43},"Seraphina","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-05","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",5,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What does the cancer diagnostic probe (CDP) aim to improve in breast surgery?","Question",{"text":63,"@type":64},"CDP targets real-time evaluation of involved breast cavity margins, improving detection during intra-operative margin shaving compared with conventional approaches such as frozen section.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How did CDP performance compare with frozen section for detecting involved margins?",{"text":68,"@type":64},"CDP increased the rate of involved margin detection to 30% relative to frozen section.",{"name":70,"@type":61,"acceptedAnswer":71},"Why is CDP considered independent from permanent pathology in this study?",{"text":72,"@type":64},"The study reports that CDP identified involved cavity side margins that were not diagnosed by permanent pathology of the tumor side interface, with 23 lesions missed as involved in permanent pathology.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},329443,1790694543,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":92,"language":93,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":94,"faqs":95,"seo_title":96,"seo_description":12,"update_tm":97,"read_time":98,"preview_page_count":4},962075114101,"https://ap-avatar.wpscdn.com/avatar/e000253a75eb197efd?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780044092746381165",8,"Abbasvandi et al. Diagnostic Pathology (2024) 19:148  \n[https://doi.org/10.1186/s13000-024-01574-2](https://doi.org/10.1186/s13000-024-01574-2)  \nDiagnostic Pathology  \n RESEARCH Open Access  \nClinical validation on role of cancer  \ndiagnostic probe in detecting the involved cavity margins missed in permanent pathology of tumor side in breast cancer surgery  \nFereshteh Abbasvandi1,2,3†, Zohreh Sadat Miripour1†, Mahdis Bayat 1,3,  \nSeyed Mohamad Sadegh Mousavi-Kiasary1, Samira Shayanfar3, Fatemeh Shojaeian1,3, Faeze Aghaei1, Fahimeh Jahanbakhshi1, Niloofar Abbasvandi1,2, Maryam Omranihashemi3, Atieh Akbari3, Morteza Yousefi3, Mohammad Hadizadeh 1, Naiemeh Shahrabi Farahani3, Parisa Hosseinpoor 1,2,4, Mohammad Parniani2, Zeinab Nourinjad2, Mohammad Abdolahad1,5* and Mohammad Esmaeil Akbari3  \nAbstract  \nCancer diagnostic probe (CDP) as a newly entered tool in real-time breast cavity margin evaluation showed great improvement in smart margin shaving intra-operatively. This system increased the rate of involved margin detection to 30% with respect to frozen section. In this study for the first time we showed the independent role of CDPin finding the involved cavity side margins which were not diagnosed by permananet pathology of their tumor side interface. Among 147 detected margins by CDP, 23 lesions with invasive component and ductal carcinoma in-situ/ ductal cancerization weren’t reported as involved margins in permanent pathology of tumor side. Our gold standard was the histology of cavity margin specimen had been scored as involved lesion by CDP. It seems that even when the permanent pathology of surgical margins is used for final declaration, role of CDP is irreplaceable. This distinguished achievement has been obtained intra-operatively in real-time by CDP while involved report in permanent pathology of tumor margins induce re-surgery for the patient.  \n†Fereshteh Abbasvandi and Zohreh Sadat Miripour contributed equally to this work.  \n*Correspondence:  \nMohammad Abdolahad[m.abdolahad@ut.ac.ir](m.abdolahad@ut.ac.ir); [abdolahad@tums.ac.ir](abdolahad@tums.ac.ir)  \n1 Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, 4563-11155, Tehran, Iran  \n2 ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, 1517964311, Tehran, Iran  \n3 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran  \n4 SEPAS Pathology Laboratory, Tehran, Iran  \n5 Cancer Institute, Imam-Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/.)[.](http://creativecommons.org/licenses/by-nc-nd/4.0/.)  \nAbbasvandi et al. Diagnostic Pathology (2024) 19:148  \nIntroduction  \nBreast cancer (BC) is the most prevalent malignant solid tumor among women worldwide, and Breast Conserving Surgery (BCS) has been proven as","cbCaie4lbSF1SvPJ","https://ap.wps.com/l/cbCaie4lbSF1SvPJ","pdf",1505635,9,"English","# Abstract\n# Introduction","[{\"question\":\"What does the cancer diagnostic probe (CDP) aim to improve in breast surgery?\",\"answer\":\"CDP targets real-time evaluation of involved breast cavity margins, improving detection during intra-operative margin shaving compared with conventional approaches such as frozen section.\"},{\"question\":\"How did CDP performance compare with frozen section for detecting involved margins?\",\"answer\":\"CDP increased the rate of involved margin detection to 30% relative to frozen section.\"},{\"question\":\"Why is CDP considered independent from permanent pathology in this study?\",\"answer\":\"The study reports that CDP identified involved cavity side margins that were not diagnosed by permanent pathology of the tumor side interface, with 23 lesions missed as involved in permanent pathology.\"}]","Clinical validation on role of cancer diagnostic probe in detecting the involved cavity margins missed in permanent pathology of tumor side in breast cancer surgery | PDF",1789984151,23,{"code":4,"msg":82,"data":100},[101,105,109,113,117,122,127,130,134,137,141],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":114,"show_sort_weight":115,"slug":116},"Comic",60,"comic",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":119,"show_sort_weight":120,"slug":121},6,"Technology",50,"technology",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":125,"slug":126},7,"Healthcare",40,"healthcare",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":128,"slug":129},30,"research-report",{"id":92,"doc_module":4,"doc_module_name":25,"category_name":131,"show_sort_weight":132,"slug":133},"Religion & Spirituality",20,"religion-spirituality",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":135,"show_sort_weight":132,"slug":136},"World Cup","world-cup",{"id":138,"doc_module":4,"doc_module_name":25,"category_name":139,"show_sort_weight":138,"slug":140},10,"Lifestyle","lifestyle",{"id":142,"doc_module":4,"doc_module_name":25,"category_name":143,"show_sort_weight":55,"slug":144},19,"General","general"]