[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-333839-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-333839-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","clinical-signature-and-associated-immune-metabolism-of-nlrp1-in-pan-cancer","Clinical signature and associated immune metabolism of NLRP1 in pan-cancer","","Inflammations have been linked to tumours, suggesting an association between NLRP1 and cancer. A systematic bioinformatic assessment evaluated NLRP1’s prognostic relevance to immune metabolism across cancer types, using TCGA and GTEx data and tools including R, GEPIA, STRING, and TISIDB. NLRP1 showed cancer-specific differential expression, and elevated levels correlated with improved outcomes in lung adenocarcinoma (LUAD) and pancreatic adenocarcinoma (PAAD). Downregulation reduced tumour metabolic activity in LUAD, and NLRP1-related mutational signatures associated with favourable prognosis. High NLRP1 expression inversely related to tumour stemness and positively to immune infiltration, supporting NLRP1 as a therapeutic target, particularly in LUAD and PAAD.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/clinical-signature-and-associated-immune-metabolism-of-nlrp1-in-pan-cancer/333839/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/clinical-signature-and-associated-immune-metabolism-of-nlrp1-in-pan-cancer/333839.png","ImageObject",300,407,{"name":42,"@type":43},"Levi","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What relationship does the study propose between NLRP1 and cancer?","Question",{"text":63,"@type":64},"The study links NLRP1 to cancer through its association with inflammation, immune regulation, and immune-metabolic processes in the tumour microenvironment.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which cancer types showed the strongest prognostic association with NLRP1?",{"text":68,"@type":64},"Elevated NLRP1 expression correlated with more favourable prognosis in lung adenocarcinoma (LUAD) and pancreatic adenocarcinoma (PAAD).",{"name":70,"@type":61,"acceptedAnswer":71},"How did NLRP1 affect tumour metabolism and immune characteristics?",{"text":72,"@type":64},"Downregulation of NLRP1 reduced tumour metabolic activity in LUAD. High NLRP1 expression also inversely correlated with tumour stemness and positively correlated with tumour immune infiltration across cancers including LUAD and PAAD.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},333839,1790143919,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","DOI: 10. 1111/jcmm.70100  \nOR I G I NAL ART I C L E  \nClinical signature and associated immune metabolism of NLRP1 in pan-cancer  \nYong Liao1,2 | Pinglian Yang3 | Cui Yang1,2 | Kai Zhuang1 | Aamir Fahira2 | Jiaojiao Wang2 | Zhiping Liu3 | Lin Yan1 | Zunnan Huang1,2   \n1Key Laboratory of Computer-Aided Drug Design of Dongguan City, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, China  \n2Key Laboratory of Big Data Mining and Precision Drug Design of Guangdong Medical University, Key Laboratory for Research and Development of Natural Drugs of Guangdong Province, School of Pharmacy, Guangdong Medical University, Dongguan, Guangdong, China 3Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, China  \nCorrespondence  \nZunnan Huang, Key Laboratory of Computer-Aided Drug Design of Dongguan City, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong 523808, China.  \nEmail: [zn_huang@gdmu.edu.cn](zn_huang@gdmu.edu.cn)  \nFunding information  \nKey Discipline Construction Project of Guangdong Medical University, Grant/ Award Number: 4SG23004G  \nAbstract  \nInflammations have been linked to tumours, suggesting a potential association between NLRP1 and cancer. Nevertheless, a systematic assessment of NLRP1's role across various cancer types currently absent. A comprehensive bioinformatic analysis was conducted to determine whether NLRP1 exhibits prognostic relevance linked to immune metabolism across various cancers. The study leveraged data from the TCGA and GTEx databases to explore the clinical significance, metabolic features, and immunological characteristics of NLRP1, employing various tools such as R, GEPIA, STRING and TISIDB. NLRP1 exhibited differential expression patterns across various cancers, with elevated expression correlating with a more favourable prognosis in lung adenocarcinoma (LUAD) and pancreatic adenocarcinoma (PAAD) . Downregulation of NLRP1 reduced tumour metabolic activity in LUAD. Moreover, the mutational signature of NLRP1 was linked to a favourable prognosis. Interestingly, high NLRP1 expression inversely correlated with tumour stemness while positively correlating with tumour immune infiltration in various cancers including LUAD and PAAD. Through extensive big data analysis, we delved into the role of NLRP1 across various tumour types, constructing a comprehensive role map of its involvement in pan-cancer scenarios. Our findings highlight the potential of NLRP1 as a promising therapeutic target specifically in LUAD and PAAD.  \nK E Y WO R D S  \nbioinformatics analysis, clinical signature, immune metabolism, NLRP1, pan-cancer  \n1 | INTRODUCTION  \nAccording to the statistics from the World Health Organization (WHO) and the International Agency for Research on Cancer (IRAC), there were 20 million new cancer cases and 9.7 million cancerrelated deaths in 2022.1 The situation has gotten worse as the  \nnumber of cancer patients has kept increasing over the past few years. Therefore, it is crucial to discover novel approaches for cancer prevention and treatment.  \nWith the deepening of tumour immune research in recent years, it has been found that cell metabolism is a key factor in regulating the tumour immune microenvironment.2 Furthermore, nutrient  \nYong Liao and Pinglian Yang contributed equally to this study.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2024 The Author(s) . Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.  \nconsumption and metabolite production can affect the immune response, and the crosstalk among various cell types, comprising tumour cells and immune cells in a certain microen","cbCainlEMzKBjzbl","https://ap.wps.com/l/cbCainlEMzKBjzbl","pdf",15061829,18,"English","# Introduction\n# Key findings and clinical significance\n## Expression and prognosis across cancers\n## Links with immune infiltration and tumor stemness\n## Metabolic effects and therapeutic implications","[{\"question\":\"What relationship does the study propose between NLRP1 and cancer?\",\"answer\":\"The study links NLRP1 to cancer through its association with inflammation, immune regulation, and immune-metabolic processes in the tumour microenvironment.\"},{\"question\":\"Which cancer types showed the strongest prognostic association with NLRP1?\",\"answer\":\"Elevated NLRP1 expression correlated with more favourable prognosis in lung adenocarcinoma (LUAD) and pancreatic adenocarcinoma (PAAD).\"},{\"question\":\"How did NLRP1 affect tumour metabolism and immune characteristics?\",\"answer\":\"Downregulation of NLRP1 reduced tumour metabolic activity in LUAD. High NLRP1 expression also inversely correlated with tumour stemness and positively correlated with tumour immune infiltration across cancers including LUAD and PAAD.\"}]","Clinical signature and associated immune metabolism of NLRP1 in pan-cancer | PDF",1790004305,45]