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This study retrospectively included patients who underwent colorectal cancer surgery between January 2016 and December 2020, analyzing recurrence or metastasis, liver metastasis, lung metastasis, and death. Multivariate logistic regression identified mesocolon fascia infiltration, lymph node counts, metastatic lymph node number, and tumor TNM stage as independent risk factors for postoperative recurrence or metastasis.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/clinical-risk-factors-and-survival-analysis-of-postoperative-recurrence-or-metastasis-of-colorectal-cancer/356559/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/clinical-risk-factors-and-survival-analysis-of-postoperative-recurrence-or-metastasis-of-colorectal-cancer/356559.png","ImageObject",300,407,{"name":92,"@type":93},"Jacob","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23",true,{"@type":101,"interactionType":102,"userInteractionCount":81},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"What does the study focus on in colorectal cancer patients?","Question",{"text":111,"@type":112},"The study focuses on clinical risk factors related to postoperative recurrence or metastasis of colorectal cancer and how these factors relate to outcomes.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"How were patients selected for the analysis?",{"text":116,"@type":112},"Patients who underwent colorectal cancer surgery between January 2016 and December 2020 were included, with additional subgroup screening for rectal and colon cancers.",{"name":118,"@type":109,"acceptedAnswer":119},"Which factors were reported as independent risk factors for postoperative recurrence or metastasis?",{"text":120,"@type":112},"Mesocolon fascia infiltration, total number of lymph nodes, number of metastatic lymph nodes, and tumor TNM stage were reported as independent risk factors for postoperative recurrence or metastasis.","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},356559,1790142138,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":138,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":139,"faqs":140,"seo_title":141,"seo_description":67,"update_tm":142,"read_time":143},962084931830,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Zhu et al. BMC Cancer (2026) 26:427 BMC Cancer  \n[https://doi.org/10.1186/s12885-026-15779-9](https://doi.org/10.1186/s12885-026-15779-9)  \nRESEARCH Open Access  \nClinical risk factors and survival analysis of postoperative recurrence or metastasis of colorectal cancer  \nHaoran Zhu1, Yuankun Cai1, ChongWei Ke1 and Huipeng Wang1*  \nAbstract  \nBackground Colorectal cancer is one of the malignant tumors, and postoperative recurrence or metastasis is a key factor to the survival of patients.  \nMethods Patients who underwent colorectal cancer surgery between January 2016 and December 2020 were included. Multivariate Logistic regression was used to analysis statistically, including recurrence or metastasis, liver metastasis, lung metastasis and death respectively.  \nResults 419 cases of colorectal cancer were included in the clinical study according to the screening criteria. Multivariate Logistic regression analysis showed that Mesocolon fascia infiltration (OR,2 . 769; 95%CI, 1.374–5. 579,  \nP = 0 . 004), Total number of lymph nodes (OR,0 . 949; 95%CI, 0 .99–0. 988, P = 0 . 011), The number of metastatic lymph nodes (OR,1 . 173; 95%CI, 1.063–1. 294, P = 0 . 001), Tumor TNM stage (P \u003C 0. 001), were independent risk factors for postoperative recurrence or metastasis of colorectal cancer. Mesocolic fascia infiltration (OR,3 . 113; 95%CI, 1.209–8. 015, P = 0 . 019) and TNM stage (P = 0 . 014) were independent risk factor for postoperative liver metastasis of colorectal cancer. TNM stage of tumor (P = 0 . 037) was an independent risk factor for pulmonary metastasis after colorectal cancer surgery.  \nConclusions Multifactor logistic regression analysis showed mesocolon fascia infiltration, total number of lymph nodes, the number of metastatic lymph nodes and tumor TNM stage were independent risk factor for postoperative recurrence and metastasis of colorectal cancer.  \nKeywords Colorectal cancer, Recurrence, Metastasis, Risk factors  \n*Correspondence: Huipeng Wang [w1596691@126.com](w1596691@126.com)  \n1Department of General Surgery, The Fifth People’s Hospital of Shanghai, Fudan University, 801 Heqing Road, Shanghai 200240, China  \n© The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/licenses/by-nc-nd/4.0/](vecommons.org/licenses/by-nc-nd/4.0/.)[.](vecommons.org/licenses/by-nc-nd/4.0/.)  \nZhu et al. BMC Cancer (2026) 26:427  \nIntroduction  \nColorectal cancer is one of the major gastrointestinal malignancies threatening human death worldwide. According to the International Agency for Research on Cancer (IARC) statistics, the number of new colorectal cancer cases in 2020 will be 1,931,600, accounting for 10% of the total number of new cancers worldwide [1]. Colorectal cancer is mainly treated by surgery, combined with chemotherapy, radiation therapy, targeted therapy and other comprehensive treatment. However, the local recurrence rate of colorectal cancer after radical surgery is about 4% to 30%. Data collected since 1990 show that the 5-year survival rate of patients w","cbCaibOh18U64dCx","https://ap.wps.com/l/cbCaibOh18U64dCx","pdf",1853543,"English","# Abstract\n# Background\n# Introduction\n# Methods\n## Study approval and cohort selection\n## Diagnostic and imaging procedures","[{\"question\":\"What does the study focus on in colorectal cancer patients?\",\"answer\":\"The study focuses on clinical risk factors related to postoperative recurrence or metastasis of colorectal cancer and how these factors relate to outcomes.\"},{\"question\":\"How were patients selected for the analysis?\",\"answer\":\"Patients who underwent colorectal cancer surgery between January 2016 and December 2020 were included, with additional subgroup screening for rectal and colon cancers.\"},{\"question\":\"Which factors were reported as independent risk factors for postoperative recurrence or metastasis?\",\"answer\":\"Mesocolon fascia infiltration, total number of lymph nodes, number of metastatic lymph nodes, and tumor TNM stage were reported as independent risk factors for postoperative recurrence or metastasis.\"}]","Clinical risk factors and survival analysis of postoperative recurrence or metastasis of colorectal cancer | PDF",1790125958,25]