[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31347":3,"doc-seo-31347":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31347,1374391974585,"Genevieve","https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c",7,"Healthcare","Clinical, Radiographic, and Biomarker Perspectives of Low-Level Laser Therapy in Regenerative Endodontic Procedures: A Randomized Clinical Study","A randomized clinical study evaluates low-level laser therapy (LLLT) as an adjunct during regenerative endodontic procedures (REPs) for necrotic immature permanent teeth across a 12-month follow-up. Twenty-eight patients were divided into a control group receiving standard REP with mock laser and an experimental group receiving standard REP plus diode dental laser irradiation. Clinical symptoms, radiographic healing, and regenerative biomarkers were assessed; only DSPP showed a significant increase with LLLT, while other biomarkers were not statistically different. Results show comparable clinical and radiographic outcomes, supporting early molecular activation but requiring larger multicenter trials.","cbCaifX24iaMeSKU","https://ap.wps.com/l/cbCaifX24iaMeSKU","pdf",1414879,1,12,"English","en","# Abstract\n## Study design and groups\n## Laser protocol and biomarker assessment\n## Clinical and radiographic outcomes\n## Biomarker findings and conclusions","[{\"question\":\"What was the primary aim of the study on LLLT in regenerative endodontics?\",\"answer\":\"To compare clinical outcomes, radiographic healing, and regenerative biomarker changes between laser-irradiated and nonirradiated groups over 12 months.\"},{\"question\":\"How were patients assigned and what did the control versus experimental groups receive?\",\"answer\":\"Twenty-eight patients with necrotic immature roots were randomized to a control group receiving standard REP with mock laser or an experimental group receiving standard REP with adjunctive LLLT.\"},{\"question\":\"Which regenerative biomarker showed a statistically significant difference after LLLT?\",\"answer\":\"DSPP expression was significantly higher in the laser group (p = 0.03), while VEGF, TGF-β, MMP-8, and PDGF-BB were not significantly different.\"}]",1779310979,30,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"clinical-radiographic-and-biomarker-perspectives-of-low-level-laser-therapy-in-regenerative-endodontic-procedures-a-randomized-clinical-study","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/healthcare/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/clinical-radiographic-and-biomarker-perspectives-of-low-level-laser-therapy-in-regenerative-endodontic-procedures-a-randomized-clinical-study/31347/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-20",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What was the primary aim of the study on LLLT in regenerative endodontics?","Question",{"text":73,"@type":74},"To compare clinical outcomes, radiographic healing, and regenerative biomarker changes between laser-irradiated and nonirradiated groups over 12 months.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"How were patients assigned and what did the control versus experimental groups receive?",{"text":78,"@type":74},"Twenty-eight patients with necrotic immature roots were randomized to a control group receiving standard REP with mock laser or an experimental group receiving standard REP with adjunctive LLLT.",{"name":80,"@type":71,"acceptedAnswer":81},"Which regenerative biomarker showed a statistically significant difference after LLLT?",{"text":82,"@type":74},"DSPP expression was significantly higher in the laser group (p = 0.03), while VEGF, TGF-β, MMP-8, and PDGF-BB were not significantly different.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]